Metabolomics and Lipidomics Reveal the Metabolic Disorders Induced by Single and Combined Exposure of Fusarium Mycotoxins in IEC-6 Cells

Foods, Journal Year: 2025, Volume and Issue: 14(2), P. 230 - 230

Published: Jan. 13, 2025

Deoxynivalenol (DON), fumonisin B1 (FB1), and zearalenone (ZEN) are typical fusarium mycotoxins that occur worldwide in foodstuffs, posing significant health hazards to humans animals. Single combined exposure of DON, FB1, ZEN leads intestinal toxicity but the toxicology mechanism research is still limited. In this study, we explored cytotoxicity effects ZEN, their combination rat epithelial cell line 6 (IEC-6) cells. Cell viability results showed potency ranking was DON > FB1. Furthermore, both + FB1 presented synergism antagonism based on a index (CI)-isobologram equation model. Integrated metabolomics lipidomics adopted explore metabolism disorders induced by mycotoxin exposure. A total 2011 metabolites 670 lipids were identified. An overlap 37 62 differential compounds confirmed after single multivariate analysis, respectively. Some endocellular antioxidants significantly downregulated groups, indicating metabolic as well antioxidant capacity damage Pathway enrichment analysis annotated ethanol production ROS CYP2E1 mainly involved disturbance ZEN. The obtained study help define singly co-existence, providing an important scientific basis for risk recognition contamination.

Language: Английский

The Role of Gut Microbiota in Traditional Chinese Medicine Processing: A General Review

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100590 - 100590

Published: Feb. 1, 2025

Language: Английский

Integrated lipid metabolomics and network pharmacology to investigate the potential mechanism of Coix seed in alleviating ulcerative colitis

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 127, P. 106744 - 106744

Published: March 28, 2025

Language: Английский