Gut microbiota regulates oxidative stress and inflammation: a double-edged sword in renal fibrosis DOI Creative Commons

Xiaojun Li,

Qiyuan Shan, X. Wu

et al.

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: Dec. 1, 2024

Gut microbiota is a complex and dynamic system that plays critical roles in human health various disease. Progressive chronic kidney disease (CKD) suggests patients irreversibly progress to end-stage need renal replacement treatments, including dialysis transplantation. Ample evidence indicates local oxidative stress inflammation play pivotal the pathogenesis progression of CKD dysbiosis gut microbiota. always accompanied by intestinal stress, which lead rapid systemic translocation bacterial-derived uraemic toxins, indoxyl sulphate, phenyl sulphate indole-3-acetic acid, consequent development aggravation fibrosis. Although have been extensively discussed, there paucity reports on effects fibrosis mediation inflammation. This review provides an overview fibrosis, briefly discusses regulation flora using microecological preparations natural products, such as resveratrol, curcumin emodin treatments for CKD, clear pathophysiological rationale design promising therapeutic strategies.

Language: Английский

Gut microbiota regulates oxidative stress and inflammation: a double-edged sword in renal fibrosis DOI Creative Commons

Xiaojun Li,

Qiyuan Shan, X. Wu

et al.

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: Dec. 1, 2024

Gut microbiota is a complex and dynamic system that plays critical roles in human health various disease. Progressive chronic kidney disease (CKD) suggests patients irreversibly progress to end-stage need renal replacement treatments, including dialysis transplantation. Ample evidence indicates local oxidative stress inflammation play pivotal the pathogenesis progression of CKD dysbiosis gut microbiota. always accompanied by intestinal stress, which lead rapid systemic translocation bacterial-derived uraemic toxins, indoxyl sulphate, phenyl sulphate indole-3-acetic acid, consequent development aggravation fibrosis. Although have been extensively discussed, there paucity reports on effects fibrosis mediation inflammation. This review provides an overview fibrosis, briefly discusses regulation flora using microecological preparations natural products, such as resveratrol, curcumin emodin treatments for CKD, clear pathophysiological rationale design promising therapeutic strategies.

Language: Английский

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