The Role of the Gut Microbiota in Female Reproductive and Gynecological Health: Insights into Endometrial Signaling Pathways DOI Creative Commons

P. Mora,

Diana Valbuena, Antonio Díez‐Juan

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 762 - 762

Published: May 9, 2025

Fertility is a dynamic, multifactorial process governed by hormonal, immune, metabolic, and environmental factors. Recent evidence highlights the gut microbiota as key systemic regulator of reproductive health, with notable impacts on endometrial function, implantation, pregnancy maintenance, timing birth. This review examines gut–endometrial axis, focusing how microbial communities influence biology through molecular signaling pathways. We discuss modulatory roles microbial-derived metabolites—including short-chain fatty acids, bile tryptophan catabolites—in shaping immune tolerance, estrogen metabolism, epithelial integrity at uterine interface. Emphasis placed shared mechanisms such β-glucuronidase-mediated recycling, Toll-like receptor (TLR)-driven inflammation, Th17/Treg cell imbalance, translocation, which collectively implicate dysbiosis in etiology gynecological disorders including endometriosis, polycystic ovary syndrome (PCOS), recurrent implantation failure (RIF), preeclampsia (PE), preterm birth (PTB). Although most current remains correlational, emerging insights from metagenomic metabolomic profiling, along microbiota-depletion models Mendelian randomization studies, underscore biological significance gut-reproductive crosstalk. By integrating concepts microbiology, immunology, biology, this offers systems-level perspective host–microbiota interactions female fertility.

Language: Английский

The Role of the Gut Microbiota in Female Reproductive and Gynecological Health: Insights into Endometrial Signaling Pathways DOI Creative Commons

P. Mora,

Diana Valbuena, Antonio Díez‐Juan

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 762 - 762

Published: May 9, 2025

Fertility is a dynamic, multifactorial process governed by hormonal, immune, metabolic, and environmental factors. Recent evidence highlights the gut microbiota as key systemic regulator of reproductive health, with notable impacts on endometrial function, implantation, pregnancy maintenance, timing birth. This review examines gut–endometrial axis, focusing how microbial communities influence biology through molecular signaling pathways. We discuss modulatory roles microbial-derived metabolites—including short-chain fatty acids, bile tryptophan catabolites—in shaping immune tolerance, estrogen metabolism, epithelial integrity at uterine interface. Emphasis placed shared mechanisms such β-glucuronidase-mediated recycling, Toll-like receptor (TLR)-driven inflammation, Th17/Treg cell imbalance, translocation, which collectively implicate dysbiosis in etiology gynecological disorders including endometriosis, polycystic ovary syndrome (PCOS), recurrent implantation failure (RIF), preeclampsia (PE), preterm birth (PTB). Although most current remains correlational, emerging insights from metagenomic metabolomic profiling, along microbiota-depletion models Mendelian randomization studies, underscore biological significance gut-reproductive crosstalk. By integrating concepts microbiology, immunology, biology, this offers systems-level perspective host–microbiota interactions female fertility.

Language: Английский

Citations

0