Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma DOI Creative Commons

Guodan Zeng,

Xinyu Liu, H. Lv

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 61 - 61

Published: Jan. 13, 2025

miRNAs are small non-coding RNA molecules that play critical roles in the regulation of gene expression and have been closely associated with various diseases, including cancer. These significantly influence cell cycle tumor cells control programmed death (apoptosis). Currently, research on has become a major focus developing cancer therapies. Osteosarcoma, malignant neoplasm predominantly occurring during adolescence later life, is characterized by high propensity for metastasis. This review explores role initiation progression cancer, highlighting their potential as predictive biomarkers disease. It discusses mechanisms which natural products modulate miRNA activity to apoptosis, ferroptosis, autophagy osteosarcoma cells, aiming identify new strategies treatment. Recent studies how regulate reduce resistance chemotherapy also reviewed. Furthermore, elaborates m6A modifications expression, thereby exerting antitumor effects. In this process, interactions between identified, both jointly influencing tumorigenesis progression, offering perspective approaches could help uncover novel regulatory pathways provide theoretical foundation drugs identifying therapeutic targets.

Language: Английский

Silencing long non‐coding RNA linc00689 suppresses the growth and invasion of osteosarcoma cells by targeting miR‐129‐5p/NUSAP1 DOI Open Access
Ling Zhang,

Jingtao Song,

Xin Xu

et al.

International Journal of Experimental Pathology, Journal Year: 2025, Volume and Issue: 106(2)

Published: Jan. 31, 2025

Long non-coding RNAs (lncRNAs) have been reported to play a critical role in the progression and metastasis of osteosarcoma. Recently, long intergenic non-protein coding RNA 689 (linc00689) has shown be involved glioma. However, precise linc00689 osteosarcoma is unknown. In this study, our data demonstrated that silencing by siRNA markedly suppressed proliferation, migration, invasion epithelial-mesenchymal transition (EMT) MG63 SAOS-2 cells. Bioinformatics analysis dual-luciferase reporter assay revealed could bind miR-129-5p. Moreover, NUSAP1 was target miR-129-5p positively regulated linc00689. Further, overexpression enhanced cell behaviour abolished inhibitory effects knockdown on EMT conclusion, exerts an oncogenic osteosarcoma, which works via miR-129-5p/NUSAP1 axis.

Language: Английский

Citations

0
Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma DOI Creative Commons

Guodan Zeng,

Xinyu Liu, H. Lv

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 61 - 61

Published: Jan. 13, 2025

miRNAs are small non-coding RNA molecules that play critical roles in the regulation of gene expression and have been closely associated with various diseases, including cancer. These significantly influence cell cycle tumor cells control programmed death (apoptosis). Currently, research on has become a major focus developing cancer therapies. Osteosarcoma, malignant neoplasm predominantly occurring during adolescence later life, is characterized by high propensity for metastasis. This review explores role initiation progression cancer, highlighting their potential as predictive biomarkers disease. It discusses mechanisms which natural products modulate miRNA activity to apoptosis, ferroptosis, autophagy osteosarcoma cells, aiming identify new strategies treatment. Recent studies how regulate reduce resistance chemotherapy also reviewed. Furthermore, elaborates m6A modifications expression, thereby exerting antitumor effects. In this process, interactions between identified, both jointly influencing tumorigenesis progression, offering perspective approaches could help uncover novel regulatory pathways provide theoretical foundation drugs identifying therapeutic targets.

Language: Английский

Citations

0