Epigenetic modifications in cardiac fibrosis: recent evidence of new pharmacological targets DOI Creative Commons
M. Sánchez Pérez, Mónica Gómez, Jairo Castellar-López

et al.

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: May 2, 2025

Cardiac fibrosis (CF) is characterized by the excessive deposition of collagen types I (COI I) and III III), primarily mediated cardiac fibroblasts (CFB). Recent advances in epigenetic research have enhanced our understanding molecular mechanisms underlying CF facilitated identification novel therapeutic strategies targeting key proteins signaling pathways involved its progression. Epigenetic modifications, including DNA methylation, histone non-coding RNAs (ncRNAs), are structural chemical alterations that regulate gene expression cellular responses without changing sequence. Investigating role enzymes may reveal promising pharmacological targets. This review summarizes current evidence on modifications implicated discusses their potential as targets for modulating this pathological process.

Language: Английский

Epigenetic modifications in cardiac fibrosis: recent evidence of new pharmacological targets DOI Creative Commons
M. Sánchez Pérez, Mónica Gómez, Jairo Castellar-López

et al.

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: May 2, 2025

Cardiac fibrosis (CF) is characterized by the excessive deposition of collagen types I (COI I) and III III), primarily mediated cardiac fibroblasts (CFB). Recent advances in epigenetic research have enhanced our understanding molecular mechanisms underlying CF facilitated identification novel therapeutic strategies targeting key proteins signaling pathways involved its progression. Epigenetic modifications, including DNA methylation, histone non-coding RNAs (ncRNAs), are structural chemical alterations that regulate gene expression cellular responses without changing sequence. Investigating role enzymes may reveal promising pharmacological targets. This review summarizes current evidence on modifications implicated discusses their potential as targets for modulating this pathological process.

Language: Английский

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