Published: Jan. 1, 2025
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1911 - 1911
Published: Feb. 23, 2025
The incidence of various inflammatory diseases has remained high. Inula cappa is a kind Chinese herbal medicine with wide range pharmacological uses and application value. It anti-inflammatory, antibacterial, antioxidant, hepatoprotective other activities. monomeric compounds that have been confirmed to anti-inflammatory effects are luteolin, chrysoerilol, artemetin, chlorogenic acid, neochlorogenic cryptchlorogenic isochlorogenic acid A, B, C 1,3-O-dicaffeoylquinic acid. This article introduces the relationship between inflammation, components I. cappa, modulation each component on transduction signal pathway, TLR2/MyD88/NF-KB signaling providing theoretical basis for research clinical medication using cappa.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: March 7, 2025
Background Early diagnosis and treatment of endometriosis (EM) remain challenging because the lack knowledge about EM development. While oxidative stress (OS) has been associated with EM, link is unclear. We explored OS-related genes (OSRGs) their role in pathogenesis. Material methods combined two ectopic endometrium (EC) eutopic (EU) datasets (GSE11691 GSE25628) into a dataset for analysis. Bioinformatic analyses were used to identify differentially expressed (DEGs), (OSRGs), enriched pathways, competitive endogenous RNA network, immune cell infiltration. Finally, real time-quantitative polymerase chain reaction (RT-qPCR) Western blot (WB) validate expression key OSRGs clinical patient samples. Results analysis identified 459 DEGs between EC EU samples, including 67 OSRGs. A ceRNA network was established, encompassing 28 DE-OSRGs, 32 miRNAs, 53 lncRNAs. Four ( CYP17A1 , NR3C1 ENO2 NGF ) selected from protein-protein interaction The RT-qPCR WB showed that these genes’ abnormal changes protein levels consistent data public databases. Weighted gene co-expression three immune-related CYP17A1, NR3C1, 20 lncRNAs may regulate through 10 miRNAs. Conclusion function via multilayered networks EM. provide insights underscore potential significance environment diagnostic prognosis evaluation.
Language: Английский
Citations
0
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(5), P. e0322710 - e0322710
Published: May 7, 2025
Psoriasis is a chronic, immune-mediated inflammatory skin disease, and the response plays an important role in its development progression. can appear at any age occurs around world. The pathogenesis of psoriasis has not been fully elucidated, there currently no effective treatment method clinical practice. Broussonetia papyrifera traditional Chinese medicine that exhibited significant therapeutic effect on our previous study due to remarkable anti-inflammatory anti-oxidant properties. However, mechanism action treating still unclear. purpose this evaluate anti-psoriasis B. leaves extract (PLE) vivo explore potential effects. PLE effectively alleviated imiquimod (IMQ)-induced psoriasis-like lesions, reduced lesion area severity index, decreased epidermal hyperplasia, ameliorated oxidative stress-induced changes levels superoxide dismutase (SOD) malondialdehyde (MDA), cytokines TNF-α IL-17A. also reduce protein expression TLR4, MyD88, p-NF-κBp65, p-IκBα, p-PI3K p-AKT induced by IMQ model. Our findings suggest improving symptoms, which might be ascribed inhibition TLR4/NF-κB PI3K/AKT inflammation pathway. demonstrates natural source for psoriasis. it note these lack validation, further studies are required validate results settings. Additionally, shows being cost-effective alternative compared existing biologics, could have broader implications future.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0