Urolithin as a Metabolite of Ellagitannins and Ellagic Acid from Fruits and Nuts Produced by the Gut Microbiota: Its Role on Non-Communicable Diseases

Current Nutrition Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: April 3, 2025

Language: Английский

Update on the correlation between mitochondrial function and osteonecrosis of the femoral head osteocytes

Redox Report, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 18, 2025

Mitochondrial health is maintained in a steady state through mitochondrial dynamics and autophagy processes. Recent studies have identified healthy mitochondria as crucial regulators of cellular function survival. This process involves adenosine triphosphate (ATP) synthesis by oxidative phosphorylation (OXPHOS), regulation calcium metabolism inflammatory responses, intracellular stress management. In the skeletal system, they participate behaviors responses osteoblasts, osteoclasts, chondrocytes, osteocytes to external stimuli. Indeed, damage or dysfunction occurs development few bone diseases. For example, may lead an imbalance osteoblasts resulting osteoporosis, osteomalacia, poor production, chondrocyte death infiltration osteoarthritis are main causes cartilage degeneration due damage. However, opposite exists for osteosarcoma, where overactive able accelerate proliferation migration osteosarcoma cells, which major disease feature. Bone dynamic organ play fundamental role all regions tissue involved regulating integrity. review examines impact physiological on osteocyte summarizes microscopic molecular mechanisms underlying its effects. It highlights that targeted therapies focusing be beneficial survival, providing new insight diagnosis, prevention, treatment diseases associated with death.

Language: Английский

Lupeol mitigates spinal cord injury by modulating microglial M1/M2 polarization via Na+/K+-ATPase-mediated mitophagy

Cellular Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 104955 - 104955

Published: April 1, 2025

Language: Английский