Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation DOI Creative Commons
Eva M. Pålsson‐McDermott, Luke O'neill

Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

The reprogramming of metabolic pathways and processes in immune cells has emerged as an important aspect the response. Metabolic intermediates accumulate a result adaptations mediate functions outside metabolism regulation immunity inflammation. In macrophages, there been major focus on 3 metabolites linked to Krebs cycle, itaconate, succinate, fumarate, which have shown regulate multiple processes. Here, we discuss recent progress these with regard their effect macrophages host defense inflammatory diseases. We also consider therapeutic opportunities presented from mimicry or by targeting enzymes that make metabolize them order leverage body's own anti-inflammatory

Language: Английский

Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation DOI Creative Commons
Eva M. Pålsson‐McDermott, Luke O'neill

Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

The reprogramming of metabolic pathways and processes in immune cells has emerged as an important aspect the response. Metabolic intermediates accumulate a result adaptations mediate functions outside metabolism regulation immunity inflammation. In macrophages, there been major focus on 3 metabolites linked to Krebs cycle, itaconate, succinate, fumarate, which have shown regulate multiple processes. Here, we discuss recent progress these with regard their effect macrophages host defense inflammatory diseases. We also consider therapeutic opportunities presented from mimicry or by targeting enzymes that make metabolize them order leverage body's own anti-inflammatory

Language: Английский

Citations

0