Augmented Marshmallow Extract Lipid Nanoparticles with Clove Oil Embedded in Collagen Sponge for Ultimate Antimicrobial Healing of Diabetic Mouth Ulcer DOI Creative Commons
Sammar Fathy Elhabal,

Ahmed Mohsen Faheem,

Sandra Hababeh

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 611 - 611

Published: May 5, 2025

Background/Objectives: Diabetic mouth ulcers are a pathological condition of the oral mucosa leading to increases in susceptibility infection and prolonged wound healing time. Still, there is lack natural formulations for treating this condition. Our principal objective was formulate solid lipid nanoparticles (SLNs) that contained Althaea officinalis (marshmallow) (M.) extract with clove oil (CO.), subsequently integrated into collagen sponge enhancing stability, solubility, sustained release, antimicrobial efficacy, power when targeting diabetic ulcers. Methods: A factorial design 34 trials established evaluate influence concentration (A), SAA (B), type (C), (D). The optimized M-CO-SLNs selected using Design Expert®, based Poly dispersibility index (Y2), zeta potential (MV) (Y3), encapsulation efficiency (%) (Y4). SLNs were matrix tested their antibacterial antifungal efficacy against Pseudomonas aeruginosa, Escherichia coli, Candida albicans, respectively. Moreover, they ulcer model. Results: formula (Run 16: 5% concentration, 4% capric acid) demonstrated P.S (110 ± 0.76 nm), ZP (−24 0.32 mV), PDI (0.18 0.05), EE% (90 0.65%.). incorporated cross-linked showed superior an increased swelling ratio, effective vivo study, as evidenced by ELISA biomarkers, gene expression analysis, histological analysis. Conclusions: embedded sponges promising therapeutic clinical application

Language: Английский

Augmented Marshmallow Extract Lipid Nanoparticles with Clove Oil Embedded in Collagen Sponge for Ultimate Antimicrobial Healing of Diabetic Mouth Ulcer DOI Creative Commons
Sammar Fathy Elhabal,

Ahmed Mohsen Faheem,

Sandra Hababeh

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 611 - 611

Published: May 5, 2025

Background/Objectives: Diabetic mouth ulcers are a pathological condition of the oral mucosa leading to increases in susceptibility infection and prolonged wound healing time. Still, there is lack natural formulations for treating this condition. Our principal objective was formulate solid lipid nanoparticles (SLNs) that contained Althaea officinalis (marshmallow) (M.) extract with clove oil (CO.), subsequently integrated into collagen sponge enhancing stability, solubility, sustained release, antimicrobial efficacy, power when targeting diabetic ulcers. Methods: A factorial design 34 trials established evaluate influence concentration (A), SAA (B), type (C), (D). The optimized M-CO-SLNs selected using Design Expert®, based Poly dispersibility index (Y2), zeta potential (MV) (Y3), encapsulation efficiency (%) (Y4). SLNs were matrix tested their antibacterial antifungal efficacy against Pseudomonas aeruginosa, Escherichia coli, Candida albicans, respectively. Moreover, they ulcer model. Results: formula (Run 16: 5% concentration, 4% capric acid) demonstrated P.S (110 ± 0.76 nm), ZP (−24 0.32 mV), PDI (0.18 0.05), EE% (90 0.65%.). incorporated cross-linked showed superior an increased swelling ratio, effective vivo study, as evidenced by ELISA biomarkers, gene expression analysis, histological analysis. Conclusions: embedded sponges promising therapeutic clinical application

Language: Английский

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