Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications

Molecular Psychiatry, Journal Year: 2021, Volume and Issue: 27(1), P. 445 - 465

Published: April 19, 2021

Language: Английский

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Neuronal circuitry for recognition memory of object and place in rodent models

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 141, P. 104855 - 104855

Published: Sept. 8, 2022

Language: Английский

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Hippocampal astrocytes modulate anxiety-like behavior

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Nov. 7, 2022

Abstract Astrocytes can affect animal behavior by regulating tripartite synaptic transmission, yet their influence on affective remains largely unclear. Here we showed that hippocampal astrocyte calcium activity reflects mouse state during virtual elevated plus maze test using two-photon imaging in vivo. Furthermore, optogenetic activation elevating intracellular induced anxiolytic behaviors astrocyte-specific channelrhodopsin 2 (ChR2) transgenic mice (hGFAP-ChR2 mice). As underlying mechanisms, found ATP released from the activated astrocytes increased excitatory transmission dentate gyrus (DG) granule cells, which exerted effects. Our data uncover a role of modulating anxiety-like ATP-mediated homeostasis DG cells. Thus, manipulating be therapeutic strategy to treat anxiety.

Language: Английский

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Information sharing within a social network is key to behavioral flexibility—Lessons from mice tested under seminaturalistic conditions

Science Advances, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 3, 2025

Being part of a social structure offers chances for learning vital survival and reproduction. Nevertheless, studying the neural mechanisms under laboratory conditions remains challenging. To investigate impact socially transmitted information about rewards on individual behavior, we used Eco-HAB, an automated system monitoring voluntary behavior group-housed mice seminaturalistic conditions. In these settings, male spontaneously form networks, with individuals occupying diverse positions. We show that rewarded group member’s scent affects ability conspecifics to search in familiar novel environments. The scent’s depends animal’s position. Furthermore, disruption neuronal plasticity prelimbic cortex (PL) disrupts networks animals’ interest related rewards; only latter is blocked by acute PL inhibition. This experimental design represents cutting-edge approach brain learning.

Language: Английский

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Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Feb. 22, 2022

Abstract Short-term memory deficits have been associated with prefrontal cortex (PFC) dysfunction in Alzheimer’s disease (AD) and AD mouse models. Extratelencephalic projection (ET) neurons the PFC play a key role short-term working memory, but mechanism between ET neuronal impairment is not well understood. Here, using fiber photometry optogenetics, we found reduced neural activity medial (mPFC) of 5×FAD model led to object recognition (ORM) deficits. Activation mPFC mice rescued ORM impairment, inhibition wild type impaired expression. that project supramammillary nucleus were necessary for Viral tracing vivo recording revealed received fewer cholinergic inputs from basal forebrain mice. Furthermore, activation fibers mice, while acetylcholine deficiency response familiar objects. Taken together, our results behind

Language: Английский

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Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum suppresses interaction with familiar mice

Cell, Journal Year: 2023, Volume and Issue: 186(19), P. 4152 - 4171.e31

Published: Sept. 1, 2023

Language: Английский

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The hippocampus associated GABAergic neural network impairment in early-stage of Alzheimer's disease

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 86, P. 101865 - 101865

Published: Jan. 28, 2023

Language: Английский

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Social Play Behavior Is Critical for the Development of Prefrontal Inhibitory Synapses and Cognitive Flexibility in Rats

Journal of Neuroscience, Journal Year: 2022, Volume and Issue: 42(46), P. 8716 - 8728

Published: Oct. 17, 2022

Sensory driven activity during early life is critical for setting up the proper connectivity of sensory cortices. We ask here whether social play behavior, a particular form interaction that highly abundant postweaning development, equally important connections in developing prefrontal cortex (PFC). Young male rats were deprived from with peers period when behavior normally peaks [postnatal day 21–42] (SPD rats), followed by resocialization until adulthood. recorded synaptic currents layer 5 cells slices medial PFC adult SPD and control observed inhibitory reduced slices, while excitatory unaffected. This was associated decrease perisomatic synapses parvalbumin-positive GABAergic cells. In parallel experiments, achieved more reversals probabilistic reversal learning (PRL) task, which depends on integrity PFC, using simplified cognitive strategy than controls. Interestingly, we one daily hour partially rescued behavioral performance PRL, but did not prevent inputs. Our data demonstrate importance unrestricted development skills adulthood show specific alterations can result complex outcome. SIGNIFICANCE STATEMENT study addressed question juvenile contributes to functional found had been (social deprivation - SPD) showed reduction solve task Providing these rats, synapses. results key role emphasize relation between circuit function.

Language: Английский

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Regulation of Social Recognition Memory in the Hippocampal Circuits

Frontiers in Neural Circuits, Journal Year: 2022, Volume and Issue: 16

Published: March 30, 2022

Social recognition memory reflects the ability of social animals to recognize and remember familiar individuals same species. The unique for mammals conspecifics is essential beneficial when conduct daily activities. This brief review summarizes a brain network underlying explores possible relationships between isolation memory. Finally, we introduce some related molecular mechanisms These findings help us explore potential targeting areas or circuits communication disorder.

Language: Английский

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Maternal high-fat diet in mice induces cerebrovascular, microglial and long-term behavioural alterations in offspring

Communications Biology, Journal Year: 2022, Volume and Issue: 5(1)

Published: Jan. 11, 2022

Abstract Various environmental exposures during pregnancy, like maternal diet, can compromise, at critical periods of development, the neurovascular maturation offspring. Foetal exposure to high-fat diet (mHFD), common Western societies, has been shown disturb development in neonates and long-term permeability neurovasculature. Nevertheless, effects mHFD on offspring’s cerebrovascular health remains largely elusive. Here, we sought address this knowledge gap by using a translational mouse model exposure. Three-dimensional ultrastructure analysis unit (vasculature parenchymal cells) mHFD-exposed offspring revealed major alterations organization metabolism. These were accompanied changes expression genes involved metabolism immunity, indicating that may result from abnormal brain immune regulation. In addition, showed persisting behavioural reminiscent neurodevelopmental disorders, specifically an increase stereotyped repetitive behaviours into adulthood.

Language: Английский

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