Pain perception as hierarchical Bayesian inference: A test case for the theory of constructed emotion

Annals of the New York Academy of Sciences, Journal Year: 2024, Volume and Issue: 1536(1), P. 42 - 59

Published: June 1, 2024

Abstract An intriguing perspective about human emotion, the theory of constructed emotion considers emotions as generative models according to Bayesian brain hypothesis. This brings fresh insight existing findings, but its complexity renders it challenging test experimentally. We argue that laboratory studies pain could support because although some may not consider be a genuine must at minimum able explain perception and dysfunction in pathology. review emerging evidence bear on this question. cover behavioral neural computational models, placebo hyperalgesia, chronic pain. conclude there is substantial for predictive processing account painful experience, paving way better understanding neuronal mechanisms other emotions.

Language: Английский

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Expectation of pain and relief: A dynamical model of the neural basis for pain-trauma co-morbidity

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 163, P. 105750 - 105750

Published: June 6, 2024

Language: Английский

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A Computational Framework for Understanding the Impact of Prior Experiences on Pain Perception and Neuropathic Pain

PLoS Computational Biology, Journal Year: 2024, Volume and Issue: 20(10), P. e1012097 - e1012097

Published: Oct. 31, 2024

Pain perception is influenced not only by sensory input from afferent neurons but also cognitive factors such as prior expectations. It has been suggested that overly precise priors may be a key contributing factor to chronic pain states neuropathic pain. However, it remains an open question how in favor of might arise. Here, we first verify Bayesian approach can describe statistical integration expectations and results phenomena placebo hypoalgesia, nocebo hyperalgesia, pain, spontaneous Our indicate the value prior, which determined internal model parameters, contributor these phenomena. Next, apply hierarchical update parameters based on difference between predicted perceived reflect people integrate experiences their future In contrast with simpler approaches, this structure able show for hypoalgesia hyperalgesia arise form classical conditioning procedure. We demonstrate phenomenon offset analgesia, disproportionally large decrease obtained following minor reduction noxious stimulus intensity. Finally, turn simulations where our corroborates persistent non-neuropathic risk developing denervation, additionally offers interesting prediction complete absence informative painful could similar factor. Taken together, provide insight contribute perception, both experimental improving strategies prevention relief.

Language: Английский

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Photobiomodulation as a Therapeutic Strategy in Burning Mouth Syndrome: A Scoping Review

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(15), P. 8880 - 8880

Published: Aug. 1, 2023

Burning mouth syndrome (BMS) is considered an atypical oral clinical-symptomatological condition because its etiopathogenesis not yet fully clarified. It mainly characterized by the symptom of burning, which occurs chronically and with various intensities. essential for making a diagnosis BMS, clinical negativities, instrumental investigations. affects female sex, in pre-post-climactic phases. A peripheral neuropathic matrix pain symptoms has been repeatedly demonstrated. However, this subjectivity associated personalities anxiety-depressive traits, affective-behavioral difficulties, disorders psycho-algogenic sphere. Numerous treatments are reported literature, have rarely met lasting healing parameters. In landscape, photobiomodulation therapy (PBMT) can be possible therapeutic alternative. Our study aims to present scoping review how used BMS analyze outcome therapy. literature focused on treatment burning was conducted main scientific databases: PubMed, SCOPUS, Web Science. The results our research highlight encouraging regarding photobiomodulation, as all studies, there reduction symptoms.

Language: Английский

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Lifeworlds in pain: a principled method for investigation and intervention

Neuroscience of Consciousness, Journal Year: 2023, Volume and Issue: 2023(1)

Published: Jan. 1, 2023

The experience of pain spans biological, psychological and sociocultural realms, both basic complex, it is by turns necessary devastating. Despite an extensive knowledge the constituents pain, ability to translate this into effective intervention remains limited. It suggested that current, multiscale, medical approaches, largely informed biopsychosocial (BPS) model, attempt integrate but are undermined epistemological obligation, one necessitates a prior isolation constituent parts. To overcome impasse, we propose anthropological stance needs be taken, underpinned Bayesian apparatus situated in computational psychiatry. Here, presented within context lifeworlds, where attention shifted away from (e.g. nociception, reward processing fear-avoidance), towards dynamic affiliation occurs between these processes over time. We argue can derive principled method investigation for modelling approaches suggest methods provide navigate multiscale ontology epistemology pain. Finally, unified approach presented, relational, inter-subjective phenomenology brought contact with translation; so doing, revealing conditions possibilities lifeworlds

Language: Английский

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Unveiling the Nexus of Cervical Proprioception, Postural Stability, and Impeding Factors in Cervical Spondylosis: Insights from Reposition Errors, Limits of Stability, and Mediation Analysis

Applied Sciences, Journal Year: 2023, Volume and Issue: 14(1), P. 193 - 193

Published: Dec. 25, 2023

Cervical proprioception and postural stability play crucial roles in maintaining optimal head neck positioning, yet their relationship implications cervical spondylosis (CS) remain underexplored. This study aims to investigate proprioceptive reposition errors, limits of stability, association individuals with CS while considering the mediating effects pain kinesiophobia. The primary objectives are compare errors variables between age-matched healthy controls, explore associations within group, determine A cross-sectional recruited 60 controls. joint (JREs) were assessed using a range-of-motion device, evaluated computerized dynamic posturography system. Pain, kinesiophobia, demographic data collected. Parametric tests, correlation analyses, multiple regression employed for analysis. Individuals exhibited significantly higher JREs flexion, extension, rotation compared controls (p < 0.001). Within correlations revealed limits-of-stability 0.05). Mediation analysis demonstrated significant direct indirect kinesiophobia on group 0.005). is associated impaired proprioception, increased compromised stability. highlights interplay pain, psychological factors, emphasizing need comprehensive interventions enhance functional outcomes quality life.

Language: Английский

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