bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: July 26, 2023
Abstract
A
preclinical
model
of
cue
exposure
therapy,
extinction,
reduces
cue-induced
cocaine
seeking
when
drug
is
goal-directed
but
not
habitual.
Goal-directed
and
habitual
behaviors
differentially
rely
on
the
dorsomedial
striatum
(DMS)
dorsolateral
(DLS),
effects
extinction
dorsal
striatal
responses
to
are
unknown.
We
used
fiber
photometry
examine
how
intracellular
calcium
extracellular
dopamine
activity
differs
between
it
impacted
by
extinction.
Rats
trained
self-administer
paired
with
an
audiovisual
schedules
reinforcement
that
promote
or
had
different
patterns
cue-reinforced
lever
presses.
Cue
reduced
during
subsequent
in
DMS,
DLS.
Therefore,
may
reduce
behavior
through
its
whereas
DLS
unaffected.
Journal of the Experimental Analysis of Behavior,
Journal Year:
2023,
Volume and Issue:
121(1), P. 8 - 26
Published: Nov. 27, 2023
Abstract
Habits
have
garnered
significant
interest
in
studies
of
associative
learning
and
maladaptive
behavior.
However,
habit
research
has
faced
scrutiny
challenges
related
to
the
definitions
methods.
Differences
conceptualizations
habits
between
animal
human
create
difficulties
for
translational
research.
Here,
we
review
commonly
used
methods
studying
animals
humans
discuss
potential
alternative
ways
assess
habits,
such
as
automaticity.
To
better
understand
then
focus
on
behavioral
factors
that
been
shown
make
or
break
animals,
well
mechanisms
underlying
influence
these
factors.
We
evidence
habitual
goal‐directed
systems
learn
parallel
they
seem
interact
competitive
cooperative
manners.
Finally,
draw
parallels
responding
compulsive
drug
seeking
delineate
similarities
differences
behaviors.
European Journal of Neuroscience,
Journal Year:
2023,
Volume and Issue:
59(2), P. 220 - 237
Published: Dec. 13, 2023
Separable
striatal
circuits
have
unique
functions
in
Pavlovian
and
instrumental
behaviors
but
how
these
roles
relate
to
performance
of
sequences
actions
with
without
associated
cues
are
less
clear.
Here,
we
tested
whether
dopamine
transmission
neural
activity
more
generally
three
subdomains
necessary
for
an
action
chain
leading
reward
delivery.
Male
female
Long-Evans
rats
were
trained
press
a
series
spatially
distinct
levers
receive
reward.
We
assessed
the
contribution
or
within
each
subdomain
when
progression
through
sequence
was
explicitly
cued
absence
cues.
Behavior
both
task
variations
substantially
impacted
following
microinfusion
antagonist,
flupenthixol,
into
nucleus
accumbens
core
(NAc)
dorsomedial
striatum
(DMS),
impairments
timing
numbers
rewards
earned
after
NAc
flupenthixol.
In
contrast,
pharmacological
inactivation
suppress
overall
activity,
there
minimal
impact
on
total
earned.
Instead,
DMS
impaired
led
errors
uncued,
not
task.
There
no
antagonism
reversible
dorsolateral
either
uncued
completion.
These
results
highlight
essential
systems
motivational
aspects
chains
actions,
internally
generated,
as
well
intact
function
correct
performance.
Addiction Neuroscience,
Journal Year:
2024,
Volume and Issue:
11, P. 100149 - 100149
Published: Jan. 28, 2024
A
preclinical
model
of
cue
exposure
therapy,
extinction,
reduces
cue-induced
cocaine
seeking
that
is
goal-directed
but
not
habit-like.
Goal-directed
and
habitual
behaviors
differentially
rely
on
the
dorsomedial
striatum
(DMS)
dorsolateral
(DLS),
effects
extinction
dorsal
striatal
responses
to
drug
are
unknown.
We
used
fiber
photometry
in
rats
trained
self-administer
paired
with
an
audiovisual
examine
how
intracellular
calcium
extracellular
dopamine
activity
differs
between
habit-like
it
impacted
by
extinction.
After
minimal
fixed-ratio
training,
showed
enhanced
DMS
DLS
cue-reinforced
compared
unreinforced
lever
presses.
were
goal-promoting
fixed
ratio
schedules
or
habit-promoting
second-order
reinforcement,
different
patterns
presses
emerged.
Rats
reduced
Cue
during
subsequent
DMS,
DLS.
Therefore,
may
reduce
behavior
through
its
whereas
unaffected.
iScience,
Journal Year:
2024,
Volume and Issue:
27(6), P. 110044 - 110044
Published: May 21, 2024
Highlights•Inhibition
of
the
dorsolateral
striatum
(DLS)
results
in
perseverative
behavior•This
behavior
is
habit-like
and
occurs
multiple
task
changes•DLS
inhibition
can
both
decrease
increase
speed
depending
on
changesSummaryThe
important
for
performing
actions
persistently,
even
when
it
becomes
suboptimal,
reflecting
a
function
that
reflexive
habitual.
However,
there
are
also
ways
which
persistent
behaviors
result
from
more
prospective,
planning
mode
behavior.
To
help
tease
apart
these
possibilities
DLS
function,
we
trained
animals
to
perform
lever
press
reward
then
inhibited
key
test
phases:
as
shifted
1-press
3-press
rule
(upshift),
was
maintained,
back
one-press
(downshift),
rewards
came
independent
pressing.
During
inhibition,
always
favored
their
initially
learned
strategy
just
once,
particularly
so
during
free-reward
period.
surprisingly
changed
performance
bidirectionally
shifts.
thus
encouraged
habitual
behavior,
suggesting
could
normally
adapt
changing
conditions.Graphical
abstract
European Journal of Neuroscience,
Journal Year:
2024,
Volume and Issue:
60(1), P. 3447 - 3465
Published: May 26, 2024
Abstract
As
opposed
to
those
requiring
a
single
action
for
reward
acquisition,
tasks
necessitating
sequences
demand
that
animals
learn
elements
and
their
sequential
order
sustain
the
behaviour
until
sequence
is
completed.
With
repeated
learning,
not
only
exhibit
precise
execution
of
these
but
also
demonstrate
enhanced
smoothness
efficiency.
Previous
research
has
demonstrated
midbrain
dopamine
its
major
projection
target,
striatum,
play
crucial
roles
in
processes.
Recent
studies
have
shown
from
substantia
nigra
pars
compacta
(SNc)
ventral
tegmental
area
(VTA)
serve
distinct
functions
learning.
The
contributions
depend
on
striatal
subregions,
namely
ventral,
dorsomedial
dorsolateral
striatum.
Here,
we
reviewed
recent
findings
role
with
focus
rodent
studies.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 17, 2024
ABSTRACT
Reward-associated
cues
serve
different
functions
depending
on
whether
they
precede
or
terminate
action
sequences.
Cues
that
sequences
and
signal
opportunity
for
reward
could
as
GO
signals
to
initiate
the
sequence,
whereas
sequence
termination
response
feedback
by
signaling
delivery.
Reward
expectation
during
execution
depends
these
might
condition
behavior
is
habitual
goal-directed.
However,
it
remains
unknown
how
initiation
differentially
affect
contribute
habit
learning.
Further,
while
mesolimbic
dopamine
plays
a
key
role
in
cue-induced
learning,
dynamic
changes
differ
strategy
unclear.
Here,
we
determined
DA
change
over
training
cue-mediated
type
of
cue
nature
behavioral
control.
We
found
sequences,
with
contributing
automaticity.
Distinct
strategies
induced
differential
captured
variations
along
execution.
Notably,
habit-like
was
associated
rapid
shift
from
retrieval
cue.
This
reflected
inflexibility
attenuated
prediction
error
signals.
Finally,
using
optogenetics,
provide
evidence
phasic
activity
elicited
critical
development
behavior.
Trends in Cognitive Sciences,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 1, 2024
Habits
are
the
behavioral
output
of
two
brain
systems.
A
stimulus-response
(S-R)
system
that
encourages
us
to
efficiently
repeat
well-practiced
actions
in
familiar
settings,
and
a
goal-directed
concerned
with
flexibility,
prospection,
planning.
Getting
balance
between
these
systems
right
is
crucial:
an
imbalance
may
leave
people
vulnerable
action
slips,
impulsive
behaviors,
even
compulsive
behaviors.
In
this
review
we
examine
how
recent
advances
our
understanding
competing
mechanisms
can
be
harnessed
increase
control
over
both
making
breaking
habits.
We
discuss
applications
everyday
life,
as
well
validated
emergent
interventions
for
clinical
populations
affected
by
As
research
area
accelerates,
anticipate
rapid
influx
new
insights
into
intentional
change
interventions,
including
opportunities
personalization
based
on
neurobiology,
environmental
context,
personal
preferences
individual.
