The ancestral shape of the access proton path of mitochondrial ATP synthases revealed by a split subunit-a DOI Creative Commons

Jonathan E. Wong,

Alena Zı́ková, Ondřej Gahura

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 26, 2023

Abstract The passage of protons across membranes through F 1 o -ATP synthases spins their rotors and drives synthesis ATP. While the principle torque generation by proton transfer is known, mechanisms routes access release evolution are not fully understood. Here, we show that entry site path in lumenal half-channel mitochondrial ATP largely defined a short N-terminal α-helix subunit-a. In Trypanosoma brucei other Euglenozoa, part another polypeptide chain product subunit-a gene fragmentation. This elements forming pathway widely conserved eukaryotes Alphaproteobacteria, closest extant relatives mitochondria, but bacteria. blocks one two found Escherichia coli , resulting single alphaproteobacterial synthases. Thus, shape predates originated lineage from which mitochondria evolved endosymbiosis.

Language: Английский

The ancestral shape of the access proton path of mitochondrial ATP synthases revealed by a split subunit-a DOI Creative Commons

Jonathan E. Wong,

Alena Zı́ková, Ondřej Gahura

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 26, 2023

Abstract The passage of protons across membranes through F 1 o -ATP synthases spins their rotors and drives synthesis ATP. While the principle torque generation by proton transfer is known, mechanisms routes access release evolution are not fully understood. Here, we show that entry site path in lumenal half-channel mitochondrial ATP largely defined a short N-terminal α-helix subunit-a. In Trypanosoma brucei other Euglenozoa, part another polypeptide chain product subunit-a gene fragmentation. This elements forming pathway widely conserved eukaryotes Alphaproteobacteria, closest extant relatives mitochondria, but bacteria. blocks one two found Escherichia coli , resulting single alphaproteobacterial synthases. Thus, shape predates originated lineage from which mitochondria evolved endosymbiosis.

Language: Английский

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