SARS-CoV-2 Antibody Profiles in Maternal Serum and Breast Milk Following mRNA COVID-19 Vaccination: A Longitudinal Prospective Observational Cohort Study DOI Creative Commons

Hui‐Mien Hsiao,

Langdon S. DiMaggio,

Maria A. Perez

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(11), P. 1643 - 1643

Published: Oct. 26, 2023

COVID-19 vaccination during pregnancy protects infants against symptomatic COVID-19. Vaccination of lactating mothers may offer additional protection, but our understanding immune responses in breast milk is limited. We, therefore, performed a single-center prospective cohort study who received mRNA primary vaccine series to evaluate the durability, breadth, and neutralizing capacity antibody milk. Spike IgG- IgA-binding antibodies ancestral SARS-CoV-2 serum were quantified over 9 months using Meso Scale Discovery (MSD) V-PLEX assays, titers compared four variants concern (Alpha, Beta, Delta, Gamma) at single time point. Neutralizing Omicron BA.4/5 before after pseudovirus-neutralization assay. Eleven either Pfizer BNT162b2 (7/11) or Moderna mRNA-1273 (4/11) series. IgG IgA increased following each dose, peaking 1-4 weeks completion. Titers remained significantly elevated for 7-9 months, except which returned baseline within 1 month. Furthermore, binding all included detected collected 1-3 However, while induced strong response more modest milk, it did not induce specimen type. This demonstrates that maternal enhance protection through via IgA-binding-and-neutralizing antibodies; although, variant-specific boosters be required optimize protection.

Language: Английский

Short‐lived neutralizing activity against SARS‐CoV‐2 in newborns of immunized mothers DOI Creative Commons
Marta Stracuzzi, Claudia Vanetti,

Micaela Garziano

et al.

Pediatric Allergy and Immunology, Journal Year: 2025, Volume and Issue: 36(4)

Published: April 1, 2025

Abstract Background Newborns under 6 months of age are at high risk hospitalization for acute respiratory failure following SARS‐CoV‐2 infection. Herein, we analyzed neonatal protection against passively acquired after mother vaccination and/or infection (hybrid immunity). Methods We enrolled seventy‐eight newborns immunized mothers before or during pregnancy, through Infants were stratified based on the anamnestic lack (SARS‐CoV‐2 Vaccinated – SV)/presence Infected and SIV) COVID‐19 maternal SARS‐CoV‐2‐specific Neutralizing Activity (NA) in plasma was assessed by virus neutralization assay (vNTA) Omicron strain delivery (T0), 3 birth (T3 T6). Cytokine chemokine profiles also analyzed. Results At birth, significantly lower NA observed infants SV compared to that SIV mothers; declined equally both groups delivery. The presence least 4 immunizing events enhances newborns, regardless type immunization (vaccination hybrid immunity) timing last immunization. Finally, cytokines chemokines levels all followed a decline over subsequent month. Conclusion Our findings suggest that, independently previous vaccination, it is reasonable upgrade recommendation booster dose pregnancy “strongly recommended” status, with view conferring first

Language: Английский

Citations

0
Milk antibody response after 3rd COVID-19 vaccine and SARS-CoV-2 infection and implications for infant protection DOI Creative Commons
Yarden Golan,

Mikias Ilala,

Lin Li

et al.

iScience, Journal Year: 2023, Volume and Issue: 26(10), P. 107767 - 107767

Published: Aug. 30, 2023

Little is known about the persistence of human milk anti-SARS-CoV-2 antibodies after 2nd and 3rd vaccine doses infection following dose. In this study, milk, saliva, blood samples were collected from 33 lactating individuals before vaccination infection. Antibody levels measured using ELISA symptoms assessed questionnaires. We found that vaccination, persisted for up to 8 months. addition, distinct patterns IgA IgG production higher RBD-blocking activity was observed compared 3-dose vaccination. Infected mothers reported more than vaccinated mothers. examined in infant saliva breastfeeding abundant IgG. Our results emphasize importance improving secretion improve protection infants.

Language: Английский

Citations

8
Effectiveness of COVID-19 vaccination in breastfeeding women in preventing SARS-CoV-2 infection in infants DOI Creative Commons
Kamolwish Laoprasopwattana, Nattaporn Tassanakijpanich, Puttichart Khantee

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

Abstract Objective: To compare the COVID-19 transmission rates between infants who were primarily breastfed and those formula fed in mothers received at least 2 doses of vaccines. Methods: A prospective longitudinal study was conducted during Omicron wave (January 1-October 1, 2022). Infants exhibited respiratory symptoms tested for SARS-CoV-2 by RT-PCR. Results: Of 234 infants, 66 (28.2%) positive SARS-CoV-2, with 63 out (95.5%) having a mother COVID-19, median (IQR) age diagnosis 11.3 (10.8-11.9) months. The proportions 6- 12-month dominant 27.0% vs. 31.0%, p =0.53 21.1% 31.3%, =0.11, respectively. In multivariate Cox regression models, both only/dominant had protected effect against hazard ratios (HRs, 95% CI) 1.50 (0.90, 2.51), =0.13 1.63 =0.09, Maternal vaccine regimens no protective HR 0.86 (0.49, 1.52), =0.61. sub-group analysis, that within 6 months 12 3.77 (0.77, 18.43), =0.05. Conclusion: Mothers have experienced can nurse without increasing risk transmission. Despite possibility breastfeeding receive shield their from virus, statistical evidence is insignificant.

Language: Английский

Citations

0
SARS-CoV-2 Antibody Profiles in Maternal Serum and Breast Milk Following mRNA COVID-19 Vaccination: A Longitudinal Prospective Observational Cohort Study DOI Creative Commons

Hui‐Mien Hsiao,

Langdon S. DiMaggio,

Maria A. Perez

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(11), P. 1643 - 1643

Published: Oct. 26, 2023

COVID-19 vaccination during pregnancy protects infants against symptomatic COVID-19. Vaccination of lactating mothers may offer additional protection, but our understanding immune responses in breast milk is limited. We, therefore, performed a single-center prospective cohort study who received mRNA primary vaccine series to evaluate the durability, breadth, and neutralizing capacity antibody milk. Spike IgG- IgA-binding antibodies ancestral SARS-CoV-2 serum were quantified over 9 months using Meso Scale Discovery (MSD) V-PLEX assays, titers compared four variants concern (Alpha, Beta, Delta, Gamma) at single time point. Neutralizing Omicron BA.4/5 before after pseudovirus-neutralization assay. Eleven either Pfizer BNT162b2 (7/11) or Moderna mRNA-1273 (4/11) series. IgG IgA increased following each dose, peaking 1-4 weeks completion. Titers remained significantly elevated for 7-9 months, except which returned baseline within 1 month. Furthermore, binding all included detected collected 1-3 However, while induced strong response more modest milk, it did not induce specimen type. This demonstrates that maternal enhance protection through via IgA-binding-and-neutralizing antibodies; although, variant-specific boosters be required optimize protection.

Language: Английский

Citations

1