Multimodal prehabilitation enhances innate antitumor immunity via NK cell recruitment DOI Open Access
Lixuan Feng,

Benjamin Gordon,

Xin Su

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 6, 2024

Abstract BACKGROUND While the clinical benefits of multimodal prehabilitation in cancer patients are well defined, underlying immune modulations have not been studied. The objective this study was to examine how can alter lung immunity. METHODS Newly diagnosed were referred clinic for preoperative personalized intervention (exercise training, nutritional optimization, and anxiety reduction) blood samples collected at baseline surgery. Tumor surgery compared matched control from who did receive prehabilitation. An animal model used tumor growth kinetics. RESULTS Twenty-eight underwent included (McGill University Health Centre Research Ethics Board #2023-9005). After prehabilitation, patient-isolated peripheral mononuclear cells (PBMCs) showed significantly increased cytotoxicity against ( p < 0.0001) circulating natural killer (NK) cohort = 0.0290) paired analyses 0.0312). Compared controls, received had more intra-tumor NK 0.0172). In vivo , we observed a significant increase 0.0364) slower 0.0396) with When depleted prehabilitated mice, decrease protective effects 0.0314) overall, correlation between reduced volume 0.0203, r -0.5143). CONCLUSIONS Multimodal may play role antitumor immunity by increasing tumour-infiltrating leading burden. Future studies on effect postoperative should be conducted.

Language: Английский

Neospora caninum Inhibits Lewis Cancer and B16f10 Melanoma Lung Metastasis Development by Activating the Immune Response in Murine Models DOI
Weifeng Qian, Yaqi Chen, Chen Li

et al.

Acta Parasitologica, Journal Year: 2025, Volume and Issue: 70(1)

Published: Feb. 1, 2025

Language: Английский

Citations

0
Exercise’s impact on lung cancer molecular mechanisms: a current overview DOI Creative Commons
Annamaria Mancini, Francesca Maria Orlandella, Daniela Vitucci

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 1, 2024

Lung cancer is the major cause of cancer-related deaths worldwide with an estimated 1.8 million and 2.4 new cases in 2022. Poor cardiorespiratory fitness, dyspnea fatigue are common features lung patients, partially limiting exercise prescription. Exercise improves muscular fitness reduces risk some types cancer, including cancer. Recently, American Society Clinical Oncology has encouraged preoperative for patients. Nonetheless, only limited data, mostly obtained from mouse models available on molecular effects Thus, present minireview aims to shed light mechanisms induced by different type In particular, role tumor microenvironment remodeling, angiogenesis, gene expression, apoptosis intermediate metabolism will be examined.

Language: Английский

Citations

0
Neospora caninum inhibits Lewis cancer and B16F10 melanoma lung metastasis development by activating the immune response in murine models DOI Creative Commons
Weifeng Qian, Yaqi Chen, Chen Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Abstract Malignant tumors are prevalent with high mortality rates in humans, dogs, and cats. Some microorganisms have been shown to inhibit cancer progression. The objective of this study is evaluate the inhibitory effects Neospora caninum, a livestock parasite, on three different tumor models C57BL/6 mice, including Lewis subcutaneous tumors, B16F10 melanoma lung metastasis. results showed that sufficient amount N. caninum tachyzoites can significantly development metastasis (P < 0.001), induce more than 50% cell death tumors. treatment increases infiltration macrophages, NK cells, CD8+ T cells 0.0001) detected by immunohistochemistry, percentage these immunocytes spleen 0.05) mice bearing flow cytometry. And changes, mRNA expression levels IL-12, IFN-γ, IL-2, IL-10, TNF-α PD-L1 microenvironment IL-2 were also increased 0.05). Altogether, our indicate not only inhibits growth but melanomas metastatic activating potent immune responses. its anti-tumor properties may be an effective tool.

Language: Английский

Citations

0
Multimodal prehabilitation enhances innate antitumor immunity via NK cell recruitment DOI Open Access
Lixuan Feng,

Benjamin Gordon,

Xin Su

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 6, 2024

Abstract BACKGROUND While the clinical benefits of multimodal prehabilitation in cancer patients are well defined, underlying immune modulations have not been studied. The objective this study was to examine how can alter lung immunity. METHODS Newly diagnosed were referred clinic for preoperative personalized intervention (exercise training, nutritional optimization, and anxiety reduction) blood samples collected at baseline surgery. Tumor surgery compared matched control from who did receive prehabilitation. An animal model used tumor growth kinetics. RESULTS Twenty-eight underwent included (McGill University Health Centre Research Ethics Board #2023-9005). After prehabilitation, patient-isolated peripheral mononuclear cells (PBMCs) showed significantly increased cytotoxicity against ( p < 0.0001) circulating natural killer (NK) cohort = 0.0290) paired analyses 0.0312). Compared controls, received had more intra-tumor NK 0.0172). In vivo , we observed a significant increase 0.0364) slower 0.0396) with When depleted prehabilitated mice, decrease protective effects 0.0314) overall, correlation between reduced volume 0.0203, r -0.5143). CONCLUSIONS Multimodal may play role antitumor immunity by increasing tumour-infiltrating leading burden. Future studies on effect postoperative should be conducted.

Language: Английский

Citations

0