Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies DOI Creative Commons
Emma Cavarocchi, Maëva Drouault, João C. Ribeiro

et al.

Andrology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize oocyte. This fundamental property is supported by flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide mechanical force for propulsion motility. Primary motility of cells acquired during their transit through epididymis hyperactivated throughout journey in a process called capacitation. These activation processes rely micro‐environment tracts. particular, capacitation, panoply ion transporters located at surface mediate complex exchanges, induce increase plasma membrane fluidity, alkalinization cytoplasm protein phosphorylation cascades are compulsory hyperactivation potential. As consequence, both structural functional defects flagellum can affect motility, resulting asthenozoospermia, constitutes most predominant pathological condition associated with human male infertility. Objectives Herein, we have performed literature review comprehensive description recent advances genetics asthenozoospermia. Results Discussion We describe currently knowledge gene mutations morphology namely, asthenoteratozoospermia; also specify exclusively function activation, discuss benefit this patient couple management, terms genetic counselling diagnosis infertility as sole phenotype or association ciliary defects. Last, current strategies been initiated development therapeutical contraceptive targeting genes essential activation.

Language: Английский

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies DOI Creative Commons
Emma Cavarocchi, Maëva Drouault, João C. Ribeiro

et al.

Andrology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize oocyte. This fundamental property is supported by flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide mechanical force for propulsion motility. Primary motility of cells acquired during their transit through epididymis hyperactivated throughout journey in a process called capacitation. These activation processes rely micro‐environment tracts. particular, capacitation, panoply ion transporters located at surface mediate complex exchanges, induce increase plasma membrane fluidity, alkalinization cytoplasm protein phosphorylation cascades are compulsory hyperactivation potential. As consequence, both structural functional defects flagellum can affect motility, resulting asthenozoospermia, constitutes most predominant pathological condition associated with human male infertility. Objectives Herein, we have performed literature review comprehensive description recent advances genetics asthenozoospermia. Results Discussion We describe currently knowledge gene mutations morphology namely, asthenoteratozoospermia; also specify exclusively function activation, discuss benefit this patient couple management, terms genetic counselling diagnosis infertility as sole phenotype or association ciliary defects. Last, current strategies been initiated development therapeutical contraceptive targeting genes essential activation.

Language: Английский

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