Recent Advances in Biomolecule‐Engineered Metal‐Organic Frameworks (Bio‐MOFs): From Design, Bioengineering, and Structural/functional Regulation to Biocatalytic Applications
Chenxi Du,
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Youyin Xu,
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Gang Wei
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et al.
The Chemical Record,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 12, 2025
Abstract
Biomolecule‐engineered
metal‐organic
frameworks
(Bio‐MOFs)
are
designed
by
incorporating
biomolecules
into
or
onto
MOFs
through
covalent
and
non‐covalent
interactions.
These
composite
exhibit
unique
catalytic
biological
activities,
making
them
highly
suitable
for
various
biocatalytic
applications.
In
this
review,
we
highlight
recent
advances
in
the
material
design,
bioengineering
methods,
structural
functional
regulation
techniques,
applications
of
Bio‐MOFs.
From
a
materials
perspective,
explore
their
structures
multifunctional
properties,
including
high
surface
area,
tunable
pore
sizes,
excellent
biocompatibility.
We
also
discuss
techniques
such
as
biomineralization
post‐synthetic
modification
that
employed
synthesis.
Furthermore,
examine
regulations
Bio‐MOFs,
which
enhance
activity
stability
interactions
with
enzymes,
peptides,
other
biomolecules.
Finally,
analyze
diverse
reactions,
biosensors/sensors,
drug
delivery,
therapy,
organic
wastewater
purification,
emerging
bio‐energy
science.
This
review
underscores
pivotal
role
enhancing
functions
aims
to
inspire
design
synthesis
novel
Bio‐MOFs
future
bio‐related
Language: Английский
Enzymatic Synthesis of Unprotected α,β-Diamino Acids via Direct Asymmetric Mannich Reactions
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(29), P. 20263 - 20269
Published: July 13, 2024
α,β-Diamino
acids
are
important
structural
motifs
and
building
blocks
for
numerous
bioactive
natural
products,
peptidomimetics,
pharmaceuticals,
yet
efficient
asymmetric
synthesis
to
access
these
stereoarrays
remains
a
challenge.
Herein,
we
report
the
development
of
pyridoxal
5'-phosphate
(PLP)-dependent
enzyme
that
is
engineered
catalyze
stereoselective
Mannich-type
reactions
between
free
α-amino
enolizable
cyclic
imines.
This
biocatalyst
enabled
one-step
enzymatic
unusual
pyrrolidine-containing
amino
acid
L-tambroline
at
gram-scale
with
high
enantio-
diastereocontrol.
Furthermore,
this
platform
capable
utilizing
diverse
range
as
Mannich
donor
various
imines
acceptor.
By
coupling
different
imine-generating
enzymes,
established
versatile
biocatalytic
cascades
demonstrated
general,
concise,
versatile,
atom-economic
approach
unprotected
α,β-diamino
acids,
including
structurally
complex
α,α-disubstituted
contiguous
stereocenters.
Language: Английский
Hematin and CuII control generations of hydroperoxyl and superoxide radicals to activate galactose oxidase for 5-hydroxymethylfurfural conversion
iScience,
Journal Year:
2023,
Volume and Issue:
26(12), P. 108452 - 108452
Published: Nov. 17, 2023
We
present
a
significant
finding
that
Cu(II)
ions
can
activate
hematin
(Hem)
to
generate
more
HOO⋅
and
O2⋅-
radicals
from
the
decomposition
of
H2O2.
Galactose
oxidase
(GO)
have
been
simultaneously
immobilized
by
coordinating
(GO&Hem@Cu(II)).
The
dioxygen
O2
be
in
situ
generated
byproduct
H2O2
Cu(II)-activated
hematin.
Ample
experimental
evidence
supports
discovery
GO
is
reactivated
O2⋅-.
For
conversion
100
mM
5-hydroxymethylfurfural
(HMF)
water,
GO&Hem@Cu(II)
(0.8
mg/mL
encapsulated)
has
achieved
99.5%
within
180
min.
In
contrast,
0.8
free
M3-5
variant
(ACS
Catalysis
2018,
8,
4025)
an
HMF
17.3%.
(1,000
mM)
(4
encapsulated),
98.8%
after
8
h
reaction.
Language: Английский