HIV capsids: orchestrators of innate immune evasion, pathogenesis and pandemicity DOI
Kate L. Morling, Mohamed ElGhazaly,

R Milne

et al.

Journal of General Virology, Journal Year: 2025, Volume and Issue: 106(1)

Published: Jan. 13, 2025

Human immunodeficiency virus (HIV) is an exemplar virus, still the most studied and best understood a model for mechanisms of viral replication, immune evasion pathogenesis. In this review, we consider earliest stages HIV infection from transport virion contents through cytoplasm to integration genome into host chromatin. We present holistic virus-host interaction during pivotal stage infection. Central process capsid. The last 10 years have seen transformation in way understand capsid structure function. review key discoveries our latest thoughts on as dynamic regulator innate chromatin targeting. also accessory proteins Vpr Vpx because they are incorporated particles where collaborate with capsids manipulate defensive cellular responses argue that effective regulation uncoating immunity define pandemic potential pathogenesis, how comparison different lineages can reveal what makes lentiviruses special.

Language: Английский

Friends and Foes: The Ambivalent Role of Autophagy in HIV-1 Infection DOI Creative Commons
Susanne Klute, Konstantin M. J. Sparrer

Viruses, Journal Year: 2024, Volume and Issue: 16(4), P. 500 - 500

Published: March 25, 2024

Autophagy has emerged as an integral part of the antiviral innate immune defenses, targeting viruses or their components for lysosomal degradation. Thus, successful viruses, like pandemic human immunodeficiency virus 1 (HIV-1), evolved strategies to counteract even exploit autophagy efficient replication. Here, we provide overview intricate interplay between and HIV-1. We discuss impact on HIV-1 replication report in detail how manipulates infected cells beyond. also highlight tissue cell-type specifics In addition, weigh exogenous modulation a putative double-edged sword against potential implications future antiretroviral therapy curative approaches. Taken together, consider both proviral roles illustrate ambivalent role pathogenesis therapy.

Language: Английский

Citations

7
HIV capsids: orchestrators of innate immune evasion, pathogenesis and pandemicity DOI
Kate L. Morling, Mohamed ElGhazaly,

R Milne

et al.

Journal of General Virology, Journal Year: 2025, Volume and Issue: 106(1)

Published: Jan. 13, 2025

Human immunodeficiency virus (HIV) is an exemplar virus, still the most studied and best understood a model for mechanisms of viral replication, immune evasion pathogenesis. In this review, we consider earliest stages HIV infection from transport virion contents through cytoplasm to integration genome into host chromatin. We present holistic virus-host interaction during pivotal stage infection. Central process capsid. The last 10 years have seen transformation in way understand capsid structure function. review key discoveries our latest thoughts on as dynamic regulator innate chromatin targeting. also accessory proteins Vpr Vpx because they are incorporated particles where collaborate with capsids manipulate defensive cellular responses argue that effective regulation uncoating immunity define pandemic potential pathogenesis, how comparison different lineages can reveal what makes lentiviruses special.

Language: Английский

Citations

0