Current Opinion in Infectious Diseases, Journal Year: 2024, Volume and Issue: 37(5), P. 402 - 406
Published: July 31, 2024
To understand the characteristics and determinants of transplacental antibody transfer against SARS-CoV-2 to compare differences between infection vaccination.
Language: Английский
Biomolecules, Journal Year: 2024, Volume and Issue: 14(4), P. 435 - 435
Published: April 3, 2024
Vaccination against SARS-CoV-2 has been demonstrated to be safe during gestation. Nevertheless, there are no robust data investigating the entity of maternal antibodies’ transmission through placenta newborn and persistence antibodies in babies’ serum. The objective this study is assess antibody kinetics among newborns first months life. Women having received one or two doses anti-SARS-CoV-2 mRNA-vaccines pregnancy at any gestational age, their newborns, were recruited followed-up over 9 months. Ninety-eight women 103 babies included. At birth, we observed a significant positive correlation between neonatal serum levels negative time since last dose mothers with doses. Over follow-up, birth level significantly decreased according number 3, 6, During registered 34 dyad infection cases. decreasing trend was slower group breastfed non-infected babies. Antibodies from vaccination efficiently transferred via potentially even breast milk. Among show relevant durability
Language: Английский
Citations
5
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 8, 2025
Vaccination is protective against severe COVID-19 disease, yet whether vaccination reduces COVID-19-associated inflammation in pregnancy has not been established. The objective of this study to characterize maternal and cord cytokine profiles acute SARS-CoV-2 "breakthrough" infection (BTI) after vaccination, compared with unvaccinated uninfected controls. 66 pregnant individuals enrolled the MGH biorepository (March 2020-April 2022) were included. Maternal sera collected from 26 21 vaccinated infection. Cord at delivery. 19 term dyads without current or prior analyzed as Cytokines quantified using Human Inflammation 20-Plex ProcartaPlex assay. There was a significantly higher incidence severe/critical illness (10/26 (38%) vs. 0/21 (0%), p<0.01). Significantly levels TNFα CD62P observed BTI (p<0.05). Network correlation analyses revealed distinct response vs individuals. Neither nor resulted elevated cytokines Multivariate demonstrate setting associated during infection, which may reflect vaccine-mediated priming immune system. A fetal inflammatory specific observed.
Language: Английский
Citations
0
Vaccines, Journal Year: 2025, Volume and Issue: 13(4), P. 376 - 376
Published: March 31, 2025
Background/Objectives: Maternal vaccination and breastfeeding are important aspects of public health that should be recommended by medical staff caring for pregnant postpartum women. We aimed to analyze factors affecting women’s likelihood dual during pregnancy their infant feeding strategies. Methods: A cross-sectional study was conducted with 953 Polish mothers. An online questionnaire used included questions on sociodemographic obstetric variables, attitudes towards COVID-19 influenza vaccination, practices. Results: reported 66.0%, 18.2%, 15.6% Increasing willingness receive vaccines significantly associated older maternal age, lower BMI, living in urban areas >100,000 residents, high levels knowledge regarding vaccination. No significant association between neonatal strategy detected. The group exclusively mothers, comparison formula- mixed-feeding women, characterized having pre-pregnancy BMI previous experience. Conclusions: Rates against seasonal (influenza COVID-19) remain low among promotion antenatal reliable information about short- long-term advantages related crucial perinatal care the mother–infant dyad. Young, primiparous women who overweight or obese targets preventive programs focused
Language: Английский
Citations
0
Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
The COVID-19 pandemic has shown the critical importance of vaccination strategies to protect vulnerable populations, including pregnant women, from severe disease and its lingering consequences. Although growing evidence demonstrates that vaccines are both safe highly beneficial during pregnancy, vaccine hesitancy among women persists, partly fueled by persistent, decade-old "urban myth" linking pregnancy neuropsychiatric disorders in children. Here, we used a mouse model passive immunization with acute respiratory syndrome coronavirus 2 spike neutralizing monoclonal antibodies (SaCoV-AB) determine effects gestational on key outcomes, maternal offspring health, behavior. We show at higher SaCoV-AB dosage, immune response is reflected elevated TNF-α levels serum, but not placenta or fetal brain, no effect outcomes. report consequences for postpartum care behavior neonatal communication signatures. Behavioral assessment adult female male after treatment revealed differences phenotypes relevant neurodevelopmental disorders. Our findings indicate preclinical model, well-tolerated, discernable impact health
Language: Английский
Citations
0
Vaccines, Journal Year: 2025, Volume and Issue: 13(5), P. 450 - 450
Published: April 24, 2025
Maternal immunization is a key strategy for protecting pregnant individuals and newborns from infectious diseases. This review examines the mechanisms benefits of maternal immunization, with focus on transplacental IgG transfer immune system interactions. We provide an overview current recommendations safety efficacy profiles vaccines, including influenza, tetanus–diphtheria–acellular pertussis (Tdap), respiratory syncytial virus (RSV), COVID-19, hepatitis B. Additionally, we analyze barriers to such as misinformation, vaccine hesitancy, disparities in healthcare access, while exploring potential strategies overcome these challenges through targeted educational initiatives, improved provider communication, policy-driven interventions aimed at increasing confidence accessibility. Finally, this highlights recent innovations future directions emerging vaccines Group B Streptococcus cytomegalovirus. Expanding programs advancing research maternal–fetal immunity are essential optimizing vaccination strategies, improving public health outcomes, reducing global burden
Language: Английский
Citations
0
Immunity, Journal Year: 2024, Volume and Issue: 57(7), P. 1681 - 1695.e4
Published: June 13, 2024
Respiratory syncytial virus (RSV) is among the most common causes of lower respiratory tract infection (LRTI) and hospitalization in infants. However, mechanisms immune control infants remain incompletely understood. Antibody profiling against attachment (G) fusion (F) proteins children less than 2 years age, with mild (outpatients) or severe (inpatients) RSV disease, indicated substantial age-dependent differences RSV-specific immunity. Maternal antibodies were detectable for first 3 months life, followed by a long window vulnerability between 6 rapid evolution FcγR-recruiting immunity after age. Acutely ill hospitalized exhibited G-specific compared healthy controls. With disease resolution, RSV-infected generated broad functional strain-specific G-responses evolved cross-reactive F-responses, minimal maternal imprinting. These data suggest an age-independent humoral correlate protection, F-specific resolution.
Language: Английский
Citations
3
Nature Immunology, Journal Year: 2024, Volume and Issue: 25(11), P. 2024 - 2036
Published: Oct. 8, 2024
Language: Английский
Citations
2
American Journal of Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
2
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: July 15, 2024
Respiratory Syncytial Virus (RSV) is associated with significant neonatal and infant morbidity mortality. Maternal bivalent RSVpreF RSV vaccination to protect neonates infants was approved in September 2023 for administration between 32+0 36+6 weeks infants. This timeframe narrower than the 24-36 week window evaluated clinical trial, due possible association preterm birth vaccine administration. Currently, data are lacking on how maternal timing within affects transfer of antibodies from mother fetus, critical information that could influence practice.
Language: Английский
Citations
1
Current Opinion in Infectious Diseases, Journal Year: 2024, Volume and Issue: 37(5), P. 402 - 406
Published: July 31, 2024
To understand the characteristics and determinants of transplacental antibody transfer against SARS-CoV-2 to compare differences between infection vaccination.
Language: Английский
Citations
0