New Potential Pharmacological Options for Endometriosis Associated Pain

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7068 - 7068

Published: June 27, 2024

Endometriosis is a chronic inflammatory disorder characterized by the abnormal growth of endometrial-like tissue outside uterine cavity, affecting 10-15% women reproductive age. Pain most common symptom. Treatment options include surgery, which has limited effectiveness and high recurrence rates, pharmacotherapy. Hormonal therapies, commonly used for symptom management, can have side effects contraceptive outcomes, contributing to infertility associated with endometriosis, pain lesions often reappearing after treatment cessation. Among its etiological factors, immunological dysregulation plays significant role, representing an interesting target developing new therapeutic strategies. This review critically analyzes recent studies provide updated synthesis ongoing research into potential pharmacotherapies focusing on lesion progression, relief, improving quality life. Immunotherapy, natural anti-inflammatory antioxidant compounds drug repurposing show promise in addressing limitations current treatments targeting potentially offering non-invasive solutions managing endometriosis. Promising results been obtained from vitro animal model studies, but clinical trials are still limited. More effort needed translate these findings practice effectively reduce disease alleviate symptoms preserve capacity, patients' overall wellbeing.

Language: Английский

Cardiovascular risks and endothelial dysfunction in reproductive-age women with endometriosis

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 15, 2024

Endometriosis is a prevalent gynecological condition, affecting around 10% of reproductive-age women. Inflammatory processes associated with endometriosis may contribute to endothelial dysfunction. Increased skin accumulation advanced glycation end-products (AGEs), reflecting arterial stiffness, potentially links elevated risk cardiovascular events. We hypothesized that patients have impaired function as well increased stiffness and AGE accumulation, compared healthy controls. function, levels AGEs in suffering from The study included 45 women aged 20 40: 21 24 controls, matched terms age, BMI, blood pressure values. Endo-PAT 2000 device was used for non-invasive assessment (i) expressed Reactive Hyperemia Index (RHI), (ii) Augmentation (AI) at 75 heart beats/min (AI@75). Endothelial dysfunction defined an RHI value ≤ 1.67. Reader evaluation level accumulation. Patients had lower mean values (1.69 ± 0.54 vs. 2.02 0.48, p = 0.037) higher prevalence dysfunction, (52.4% 20.8%, 0.027) Skin endometriosis, controls (2.00 0.57 1.70 0.24, 0.013). There were no significant differences AI AI@75 between the two groups. which are well-established preclinical manifestations risk. great need comprehensive assessments prevent development potential atherosclerotic-based complications.

Language: Английский

The correlation between immune cells and endometriosis: a bidirectional two-sample mendelian randomization study

BMC Women s Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 19, 2024

Language: Английский