Leveraging Cancer Phenotypic Plasticity for Novel Treatment Strategies DOI Open Access
Sravani Ramisetty,

Ayalur Raghu Subbalakshmi,

Siddhika Pareek

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(11), P. 3337 - 3337

Published: June 5, 2024

Cancer cells, like all other organisms, are adept at switching their phenotype to adjust the changes in environment. Thus, phenotypic plasticity is a quantitative trait that confers fitness advantage cancer cell by altering its suit environmental circumstances. Until recently, new traits, especially cancer, were thought arise due genetic factors; however, it now amply evident such traits could also emerge non-genetically plasticity. Furthermore, of cells contributes heterogeneity population, which major impediment treating disease. Finally, impacts group behavior since competition and cooperation among multiple clonal groups within population interactions they have with tumor microenvironment contribute evolution drug resistance. understanding mechanisms exploit tailor phenotypes systems level can aid development novel therapeutics treatment strategies. Here, we present our perspective on team medicine-based approach gain deeper phenomenon develop therapeutic

Language: Английский

Leveraging Cancer Phenotypic Plasticity for Novel Treatment Strategies DOI Open Access
Sravani Ramisetty,

Ayalur Raghu Subbalakshmi,

Siddhika Pareek

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(11), P. 3337 - 3337

Published: June 5, 2024

Cancer cells, like all other organisms, are adept at switching their phenotype to adjust the changes in environment. Thus, phenotypic plasticity is a quantitative trait that confers fitness advantage cancer cell by altering its suit environmental circumstances. Until recently, new traits, especially cancer, were thought arise due genetic factors; however, it now amply evident such traits could also emerge non-genetically plasticity. Furthermore, of cells contributes heterogeneity population, which major impediment treating disease. Finally, impacts group behavior since competition and cooperation among multiple clonal groups within population interactions they have with tumor microenvironment contribute evolution drug resistance. understanding mechanisms exploit tailor phenotypes systems level can aid development novel therapeutics treatment strategies. Here, we present our perspective on team medicine-based approach gain deeper phenomenon develop therapeutic

Language: Английский

Citations

2