Vitamin D deficiency and duration of COVID-19 symptoms in UK healthcare workers DOI Creative Commons
Karan R. Chadda, Sally Roberts, Sebastian T. Lugg

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 25, 2024

Objectives Vitamin D has a role in the innate immunity against pathogens and is also involved mechanisms for reducing inflammation. VD deficiency (VDD) may increase COVID-19 infection susceptibility, however research limited on association between VDD symptom prevalence duration. The study aimed to determine whether risk factor presence extended duration of symptoms. Methods Data was analyzed from NHS healthcare workers who isolated due symptoms as part convalescent 12th 22nd May 2020. Participants self-reported viral Anti-SARS-CoV-2 antibodies vitamin (25(OH)D 3 ) serum levels were measured day recruitment. defined 25(OH)D < 30 nmol/l. Results Of 392 participants, 15.6% ( n = 61) had VDD. participants more overall p 0.0030), including body aches 0.0453), 0.0075) fatigue 0.0127). Binary logistic regression found that both (OR 3.069, 95% CI 1.538–6.124; 0.001) age 1.026, 1.003–1.049; 0.025) independently associated with durations aches. 2.089, 1.087–4.011; 0.027), 1.036, 1.016–1.057; seroconversion 1.917, 1.203–3.056; 0.006), fatigue. Conclusion significant independent supplementation reduce thus an area future research.

Language: Английский

Adult Long Coronavirus Disease 2019 DOI
Ivette F. Emery, Clifford J. Rosen

Infectious Disease Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
Living with Long COVID in a Southern State: A Comparison of Black and White Residents of North Carolina DOI Open Access

William Pilkington,

Brooke E. Bauer,

Irene A. Doherty

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(2), P. 279 - 279

Published: Feb. 14, 2025

Long COVID can devastate patients' overall quality of life, extending to economic, psychosocial, and mental health day-to-day activities. Clinical research suggests that long is more severe among Black African American populations in the United States. This study examines lived lasting effects a diverse sample North Carolina residents over one year by using three self-administered questionnaires completed online Qualtrics. A cross-sectional descriptive analysis baseline results presented. Our recruited 258 adults, which 51.5% had (but may have recovered), 32.3% COVID-19 infection at least once, 16.3% never COVID-19. The socioeconomic status participants was lower than White participants; however, economic impact not worse. Across both groups, 64.4% were employed, 28.8% change tasks or work less, 19.8% stopped working. Fewer (32.6%) (54.8%) always/often felt supported family friends about having COVID. majority (59.1%) reported they did recover from compared 29.7% participants. COVID/COVID-19 experience affected differently, but continue feel impacts.

Language: Английский

Citations

0
Burden of acute and long-term COVID-19: a nationwide study in Bahrain DOI Creative Commons

Mariam Murad,

Stephen L. Atkin, Pearl Wasif

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 18, 2025

Coronavirus disease 2019 (COVID-19) may lead to long-term sequelae. This study aimed understand the acute and post-acute burden of SARS-CoV-2 infection identify high-risk groups for post-COVID-19 conditions (PCC). A retrospective observational Bahraini population was conducted between 1 May 2021 30 April 2023, utilizing national administrative database. PCC cases were defined according WHO guidelines. All COVID-19 confirmed using real-time polymerase chain reaction (PCR). Of 13,067 cases, 12,022 them experienced COVID-19, 1,045 developed PCC. Individuals with tended be older women risk factors instances reinfection. The incidence rates per 100,000 individuals during Alpha pandemic surge (2020), Delta (2021), Omicron (2022) 2.2, 137.2, 222.5 0.27, 10.5, 19.3, respectively, cases. death Alpha, Delta, surges 3, 112, 76, 1, 10, 8, rate highest among those aged 65 surge. These findings suggest need a timely vaccination program prior new prevent complications related infection, particularly in adult non-older factors.

Language: Английский

Citations

0
SARS-CoV-2 Spike Protein and Long COVID—Part 1: Impact of Spike Protein in Pathophysiological Mechanisms of Long COVID Syndrome DOI Creative Commons

Bruno Pereira de Melo,

João M. Silva,

Mariana Alves Rodrigues

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(5), P. 617 - 617

Published: April 25, 2025

SARS-CoV-2 infection has resulted in more than 700 million cases and nearly 7 deaths worldwide. Although vaccination efforts have effectively reduced mortality transmission rates, a significant proportion of recovered patients—up to 40%—develop long COVID syndrome (LC) or post-acute sequelae COVID-19 (PASC). LC is characterized by the persistence emergence new symptoms following initial infection, affecting cardiovascular, neurological, respiratory, gastrointestinal, reproductive, immune systems. Despite broad range clinical that been described, risk factors pathogenic mechanisms behind remain unclear. This review, first two-part series, distinguished discussion role spike protein primary underlying pathophysiology LC.

Language: Английский

Citations

0
The Effects of SSRIs and Antipsychotics on Long COVID Development in a Large Veteran Population DOI Creative Commons
Jerry Bradley, Fei Tang, Dominique M. Tosi

et al.

COVID, Journal Year: 2024, Volume and Issue: 4(11), P. 1694 - 1703

Published: Oct. 22, 2024

The development of Long COVID is a complex disease process that may be partially driven by neuroinflammation. Antipsychotics have been shown to exert neuroprotective effects under certain conditions. Our study aimed determine if veterans treated with antipsychotics and/or selective serotonin reuptake inhibitors (SSRIs) for psychiatric condition had reduced risk developing long-term COVID. We conducted retrospective cohort two cohorts patients based on the COVID-19 wave in which patient’s initial infection occurred (Cohort 1: alpha/beta waves, and Cohort 2: delta/omicron waves) stratification age. A multivariate logistic regression model was used evaluate association between use diagnosis. In 1, antipsychotic associated 43% 34% reductions odds aged <65 >65 years, respectively. This second 11% years without an over 65 SSRIs showed no benefit either age group or cohort. results show treatment mental health reduction COVID, magnitude this varied cohorts.

Language: Английский

Citations

1
A Machine Learning Approach to Identifying Risk Factors for Long COVID-19 DOI Creative Commons

Rhea Machado,

Reshen Soorinarain Dodhy,

Amit Sehgal

et al.

Algorithms, Journal Year: 2024, Volume and Issue: 17(11), P. 485 - 485

Published: Oct. 28, 2024

Long-term sequelae of coronavirus disease 2019 (COVID-19) infection are common and can have debilitating consequences. There is a need to understand risk factors for Long COVID-19 give impetus the development targeted yet holistic clinical public health interventions reduce its associated healthcare economic burden. Given large number variety predictors implicated spanning health-related sociodemographic factors, machine learning becomes valuable tool. As such, this study aims employ produce an algorithm predict risk, thereby identify key predisposing factors. Longitudinal cohort data were sourced from UK’s “Understanding Society: Study” (n = 601 participants with past symptomatic confirmed by serology testing). The random forest classification demonstrated good overall performance 97.4% sensitivity modest specificity (65.4%). Significant included early timing acute in pandemic, greater hours worked per week, older age financial insecurity. Loneliness having uncommon conditions lower risk. Sensitivity analysis suggested that vaccination also asthma increased results discussed emphasis on evaluating value learning; potential utility; some benefits limitations science researchers given availability commonly used statistical software.

Language: Английский

Citations

1
Vitamin D deficiency and duration of COVID-19 symptoms in UK healthcare workers DOI Creative Commons
Karan R. Chadda, Sally Roberts, Sebastian T. Lugg

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 25, 2024

Objectives Vitamin D has a role in the innate immunity against pathogens and is also involved mechanisms for reducing inflammation. VD deficiency (VDD) may increase COVID-19 infection susceptibility, however research limited on association between VDD symptom prevalence duration. The study aimed to determine whether risk factor presence extended duration of symptoms. Methods Data was analyzed from NHS healthcare workers who isolated due symptoms as part convalescent 12th 22nd May 2020. Participants self-reported viral Anti-SARS-CoV-2 antibodies vitamin (25(OH)D 3 ) serum levels were measured day recruitment. defined 25(OH)D &lt; 30 nmol/l. Results Of 392 participants, 15.6% ( n = 61) had VDD. participants more overall p 0.0030), including body aches 0.0453), 0.0075) fatigue 0.0127). Binary logistic regression found that both (OR 3.069, 95% CI 1.538–6.124; 0.001) age 1.026, 1.003–1.049; 0.025) independently associated with durations aches. 2.089, 1.087–4.011; 0.027), 1.036, 1.016–1.057; seroconversion 1.917, 1.203–3.056; 0.006), fatigue. Conclusion significant independent supplementation reduce thus an area future research.

Language: Английский

Citations

0