Advanced Targeted Drug Delivery Systems for Several Health Issues Using Nanotechnology

Advances in chemical and materials engineering book series, Journal Year: 2024, Volume and Issue: unknown, P. 441 - 460

Published: Oct. 22, 2024

Despite its advances in medicine, cancer still remains elusive for most of the conventional therapies because medications are applied to healthy tissues as well; traditional procedures frequently result significant adverse effects. This chapter provides a comprehensive overview role nanotechnology diagnosis, imaging, and treatment. The explores both passive active targeting techniques well mechanics behind medication delivery using nanoparticles. Therefore, potential improve biomarker detection imaging is investigated. Furthermore, prospect co-delivery numerous therapeutic drugs into single nanocarrier combination therapy investigated, emphasising synergistic benefits improved results possible with this strategy. Overall, emphasises how much may do enhance outcomes by offering focused, effective, least intrusive treatment options.

Language: Английский

Probing Different Lengths of the Tertiary Amine Head Group on Triglyceride-Mimetic Ionizable Lipid-Mediated siRNA Delivery

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Lipid nanoparticles (LNPs) have been utilized to deliver small interfering RNA (siRNA) treat acute liver injury. However, LNPs exhibit suboptimal lysosomal escape capabilities and biodegradability. To address these limitations, we designed triglyceride-mimetic ionizable lipids by conjugating N,N-dimethyl tertiary amine head groups the sn-2 position of triglyceride (TG) through ester bonds. These were abbreviated as 2C-TG, 3C-TG, 4C-TG, with located in β-, γ-, δ-positions linkage bond, respectively. The uniform-size prepared using ethanol dilution method. Notably, group within carbon chain is found significantly influence critical parameters, including encapsulation rate, pKa, cellular uptake, escape, lipase release, gene silencing efficiency. Our findings hold promise for improving efficacy safety LNP-based siRNA therapeutics.

Language: Английский

Lipid nanoparticles: A delicate nucleic acid delivery system to be further explored

Nano Today, Journal Year: 2024, Volume and Issue: 61, P. 102586 - 102586

Published: Dec. 7, 2024

Language: Английский