Application of Nanomaterials Targeting Immune Cells in the Treatment of Chronic Inflammation DOI Creative Commons

Zhen Ci,

Hanchi Wang, Jiaxin Luo

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13925 - 13946

Published: Dec. 1, 2024

Chronic inflammation is a common characteristic of all kinds diseases, including autoimmune metabolic and tumors. It distinguished by the presence low concentrations inflammatory factors stimulating body for an extended period, resulting in persistent state infection. This condition manifested aggregation infiltration mononuclear cells, lymphocytes, other immune leading to tissue hyperplasia lesions. Although various anti-inflammatory medications, glucocorticoids non-steroidal drugs (NSAIDs), have shown strong therapeutic effects, they lack specificity targeting ability, require high dosages, which can lead severe adverse reactions. Nanoparticle drug delivery mechanisms possess capacity minimize effect on healthy cells or tissues due their capabilities sustained release properties. However, most nanosystems only target sites rather than specific types leaving room further improvement effects nanomaterials. article reviews current research progress role diverse inflammation, focusing functions neutrophils macrophages during inflammation. provides overview domestic international applications nanomaterials targeted therapy aiming establish conceptual foundation utilization treatment chronic offer new perspectives avoidance management

Language: Английский

Potential use of nanoparticles to improve the effectiveness and safety of pharmacotherapy during pregnancy DOI Creative Commons
Ksenia Zagorodnikova, Ofelia A. Bettikher, И. Е. Зазерская

et al.

Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice, Journal Year: 2025, Volume and Issue: 4, P. 35 - 45

Published: Jan. 17, 2025

Relevance . Pharmacotherapy during pregnancy is associated with great risks for the fetus in case of therapy non-obstetric diseases mother, addition, issues improving effectiveness treatment placental pathology, thrombophilic conditions, and other complications remain a priority. Recently, possibilities using nanomaterials medicine have been actively studied, including purpose modifying delivery or distribution medicines. Objective The aim was to conduct structured analysis published literature on use therapeutic purposes pregnancy. Methods publications PubMed, Cyberleninka, eLIBRARY databases keywords “Nanoparticles” “Pregnancy” carried out, exception mentioning nanoparticles context environmental pollutants, as well diagnostic methods. Results Information provided nature that developed studied prospect An overview areas clinical application such materials provided, available evidence their safety. Conclusion Therapeutic systems containing drugs various good potential order ensure targeted drug delivery, modification bio-distribution increase efficacy reduce toxicity drugs.

Language: Английский

Citations

0
Physicochemical Design of Nanoparticles to Interface with and Degrade Neutrophil Extracellular Traps DOI Creative Commons
Preethi Raghavan,

Cynthia A. Perez,

Thomas A. Sorrentino

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(6), P. 8862 - 8874

Published: Jan. 30, 2025

Neutrophil extracellular traps (NETs) are networks of decondensed chromatin, histones, and antimicrobial proteins released by neutrophils in response to an infection. NET overproduction can cause exacerbated hyperinflammatory a variety diseases lead host tissue damage without clearance Nanoparticle drug delivery is promising avenue for creating materials that both target NETs deliver sustained amounts NET-degrading drugs alleviate hyperinflammation. Here, we study how particle physicochemical properties influence interaction leverage our findings create NET-interfacing particles. We fabricated panel particles varying sizes (200 1000 nm) charges (positive, neutral, negative) found positive charge the main driver NET-particle interaction, with smaller 200 nm having 10-fold increase binding compared larger Negative neutral were mostly noninteracting, except small negatively charged exhibited very low levels localization. Interaction strength was quantified via shear flow assays atomic force microscopy. This information leveraged DNase-loaded could adhere at degrees therefore degrade different rates vitro. Positively charged, showed highest degree led faster degradation sizes, underscoring importance design NET-targeting delivery. Overall, this work provides fundamental knowledge drivers particle-NET basis designing various disease states.

Language: Английский

Citations

0
Nanoparticle-Mediated Embryotoxicity: Mechanisms of Chemical Toxicity and Implications for Biological Development DOI
Biswajeet Acharya, Amulyaratna Behera, Srikanta Moharana

et al.

Chemical Research in Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Nanoparticles, defined by their nanoscale dimensions and unique physicochemical properties, are widely utilized in healthcare, electronics, environmental sciences, consumer products. However, increasing evidence of potential embryotoxic effects during pregnancy underscores the need for a molecular-level understanding interactions embryonic development. Nanoparticles such as titanium dioxide, silver, cerium oxide, copper quantum dots can cross placental barrier interfere with crucial developmental processes. At molecular level, they disrupt signaling pathways like Wnt Hedgehog, induce oxidative stress inflammation, cause genotoxic effects, all critical sensitive phases, organogenesis. Furthermore, these nanoparticles interact directly cellular components, including DNA, proteins, lipids, impairing function viability. Innovative strategies to mitigate nanoparticle toxicity, surface modifications incorporation biocompatible coatings, discussed solutions reduce adverse interactions. Various laboratory animal models used investigate nanoparticle-induced embryotoxicity evaluated efficacy limitations, providing insights into applicability effects. This Account examines mechanisms which compromise development emphasizes importance designing safer minimize maternal-fetal exposure risks, particularly biomedical applications.

Language: Английский

Citations

0
Application of nanotechnology and micro/nanorobots in thrombotic diseases DOI

Siqi Lv,

Liang Tang, Yu Hu

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(2), P. 100061 - 100061

Published: April 24, 2025

Language: Английский

Citations

0
Application of Nanomaterials Targeting Immune Cells in the Treatment of Chronic Inflammation DOI Creative Commons

Zhen Ci,

Hanchi Wang, Jiaxin Luo

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13925 - 13946

Published: Dec. 1, 2024

Chronic inflammation is a common characteristic of all kinds diseases, including autoimmune metabolic and tumors. It distinguished by the presence low concentrations inflammatory factors stimulating body for an extended period, resulting in persistent state infection. This condition manifested aggregation infiltration mononuclear cells, lymphocytes, other immune leading to tissue hyperplasia lesions. Although various anti-inflammatory medications, glucocorticoids non-steroidal drugs (NSAIDs), have shown strong therapeutic effects, they lack specificity targeting ability, require high dosages, which can lead severe adverse reactions. Nanoparticle drug delivery mechanisms possess capacity minimize effect on healthy cells or tissues due their capabilities sustained release properties. However, most nanosystems only target sites rather than specific types leaving room further improvement effects nanomaterials. article reviews current research progress role diverse inflammation, focusing functions neutrophils macrophages during inflammation. provides overview domestic international applications nanomaterials targeted therapy aiming establish conceptual foundation utilization treatment chronic offer new perspectives avoidance management

Language: Английский

Citations

1