RNA modifications in cancer immune therapy: regulators of immune cells and immune checkpoints DOI Creative Commons

Xiangyu Qin,

Huali Liu, Qixuan Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 20, 2024

RNA modifications are epigenetic changes that alter the structure and function of molecules, playing a crucial role in onset, progression, treatment cancer. Immune checkpoint inhibitor (ICI) therapies, particularly PD-1 blockade anti-CTLA-4 treatments, have changed landscape virous cancers, showing great potential different cancer patients, but sensitivity to these therapies is limited certain individuals. This review offers comprehensive survey functions therapeutic implications four principal modifications, highlighting significance m6A realms immune cells tumor immunotherapy. starts by providing foundational summary roles assume within cell community, focusing on T cells, NK macrophages, dendritic cells. We then discuss how influence intricate regulatory mechanisms governing expression, modulation ICI efficacy, prediction outcomes, drug targeting genes regulated modifications. Finally, we explore gene editing, vaccines, adoptive offering valuable insights into use

Language: Английский

Epigenetics-targeted drugs: current paradigms and future challenges DOI Creative Commons

Wanlin Dai,

Xinbo Qiao, Yuanyuan Fang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Nov. 26, 2024

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA modification, histone RNA remodeling, and non-coding regulation. These mechanisms their associated enzymes convey genetic information independently of base sequences, playing essential roles in organismal development homeostasis. Conversely, disruptions epigenetic landscapes critically influence the pathogenesis various human diseases. This understanding has laid robust theoretical groundwork for developing drugs that target epigenetics-modifying pathological conditions. Over past two decades, growing array small molecule targeting such as methyltransferase, deacetylase, isocitrate dehydrogenase, enhancer zeste homolog 2, have been thoroughly investigated implemented therapeutic options, particularly oncology. Additionally, numerous epigenetics-targeted are undergoing clinical trials, offering promising prospects benefits. review delineates epigenetics physiological contexts underscores pioneering studies on discovery implementation drugs. include inhibitors, agonists, degraders, multitarget agents, aiming to identify practical challenges avenues future research. Ultimately, this aims deepen epigenetics-oriented strategies further application settings.

Language: Английский

Citations

25
The Role of Long Non-Coding RNAs in Modulating the Immune Microenvironment of Triple-Negative Breast Cancer: Mechanistic Insights and Therapeutic Potential DOI Creative Commons
Yongcheng Su, Qingquan Bai, Wenqing Zhang

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 454 - 454

Published: March 20, 2025

Triple-negative breast cancer (TNBC) is a highly heterogeneous and aggressive subtype of that faces therapeutic challenges due to shortage effective targeted therapies. The complex biology TNBC renders its clinical management fraught with difficulties, especially regarding the immune microenvironment tumor. In recent years, long non-coding RNAs (lncRNAs) have been recognized as important gene regulators key roles in tumor development microenvironmental regulation. Previous studies shown lncRNAs play TNBC, including regulation escape function tumor-infiltrating cells. However, despite increasing research on lncRNAs, there are still many unanswered questions, such their specific mechanism action how effectively utilize them targets. Therefore, aim this study was review mechanisms microenvironment, explore regulatory cell infiltration, prospects potential By integrating latest results, aims provide new ideas directions for future treatment.

Language: Английский

Citations

0
Biological functions of 5-methylcytosine RNA-binding proteins and their potential mechanisms in human cancers DOI Creative Commons
Tingting Zhao, Zhe Zhang, Zhuo Chen

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 7, 2025

The 5-methylcytosine (m5C) modification is a crucial epigenetic RNA modification, which involved in the post-transcriptional regulation of genes. It plays an important role various biological processes, including cell metabolism, growth, apoptosis, and tumorigenesis. By affecting proliferation, migration, invasion, drug sensitivity tumor cells, m5C methylation vital part initiation progression tumors closely associated with poor prognosis. m5C-related proteins are categorized into three functional groups: methyltransferases (m5C writers), demethylases erasers), methyl-binding readers). This paper introduces several common methodologies for detecting methylation; reviews molecular structure functions readers, ALYREF, YBX1, YBX2, RAD52, YTHDF2, FMRP, SRSF2. further summarizes their roles regulatory mechanisms tumors, offering novel targets insights treatment.

Language: Английский

Citations

0
Comprehensive analysis of lipid metabolic signatures identified CEBPD promotes breast cancer cell proliferation DOI Creative Commons
Yu Zhao,

Huan He,

Linyan Huang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 24, 2025

Breast cancer (BRCA) remains the leading cause of cancer-related mortality worldwide, with lipid metabolism emerging as a critical factor in tumor progression that influences cell proliferation, migration, and immune response. Insights into signatures associated genes may offer new prognostic therapeutic avenues. In this study, we leveraged scRNA-seq bulk transcriptome data to assess expression patterns significance metabolism-related BRCA. Through single-cell transcriptomic analysis primary BRCA samples, identified specific set signature constructed risk model based on these signatures. This enables patient stratification by scores, supporting an integrated metabolism, landscape, clinical outcomes. Importantly, CEBPD, ABCA1, CYP27A1 independent linked functional assays revealing inhibitory role for CEBPD proliferation. Our findings underscore influence adipocytes propose potential target intervention. study provides foundation further exploration metabolism-based strategies enhance

Language: Английский

Citations

0
RNA modifications in cancer immune therapy: regulators of immune cells and immune checkpoints DOI Creative Commons

Xiangyu Qin,

Huali Liu, Qixuan Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 20, 2024

RNA modifications are epigenetic changes that alter the structure and function of molecules, playing a crucial role in onset, progression, treatment cancer. Immune checkpoint inhibitor (ICI) therapies, particularly PD-1 blockade anti-CTLA-4 treatments, have changed landscape virous cancers, showing great potential different cancer patients, but sensitivity to these therapies is limited certain individuals. This review offers comprehensive survey functions therapeutic implications four principal modifications, highlighting significance m6A realms immune cells tumor immunotherapy. starts by providing foundational summary roles assume within cell community, focusing on T cells, NK macrophages, dendritic cells. We then discuss how influence intricate regulatory mechanisms governing expression, modulation ICI efficacy, prediction outcomes, drug targeting genes regulated modifications. Finally, we explore gene editing, vaccines, adoptive offering valuable insights into use

Language: Английский

Citations

2