Uncovering temperature sensitivity of West Nile virus transmission: Novel computational approaches to mosquito-pathogen trait responses

PLoS Computational Biology, Journal Year: 2025, Volume and Issue: 21(3), P. e1012866 - e1012866

Published: March 31, 2025

Temperature influences the transmission of mosquito-borne pathogens with significant implications for disease risk under climate change. Mathematical models infections rely on functions that capture mosquito-pathogen interactions in response to temperature accurately estimate dynamics. For deriving these functions, experimental studies provide valuable data sensitivity mosquito life-history traits and pathogen transmission. However, scarcity inconsistencies methodologies analysing responses across species, pathogens, experiments present major challenges. Here, we introduce a new approach address We apply this framework study thermal biology West Nile virus (WNV). reviewed existing studies, obtaining eight 15 species. Using data, employed Bayesian hierarchical each trait their variation between species experiments. incorporated resulting into mathematical WNV transmission, focusing six genus Culex . Our finds general optimal around 24°C among only small species-specific deviations. demonstrate differing mechanistic assumptions underlying published population result optima estimates differ by up 3°C. Additionally, find substantial variability same possibly indicating intra-species performance. identify biting rate, lifespan, egg viability as priorities future experiments, they strongly influence limits, optima, overall uncertainty suitability. Experimental vector competence are also essential, because limited currently require model simplifications. These would enhance accuracy our estimates, critical anticipating shifts

Language: Английский

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Temperature influences West Nile virus evolution and adaptation

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract body West Nile virus (WNV), the most common mosquito-borne disease in continental U.S., is vectored by Culex spp. mosquitoes. Since its introduction to New York State (NYS) 1999, WNV has become endemic. NYS temperatures have risen 0.14°C per decade since 1900, with larger increases linked higher transmission. Using surveillance and sequencing data, we find a significant correlation between rising temperatures, increased genetic diversity, prevalence. Given experimentally demonstrated role of temperature influencing fitness, hypothesized that contemporary strains should exhibit greater fitness mosquitoes at compared historic strains. To test this, analyzed genetically distinct from collected during recent warm summers (2017 2018) cooler (2003 2004). Assessing pipiens vector competence calculating relative R₀ 20°C, 24°C, 28°C, found transmission potential temperatures. Our results show possess phenotypic genotypic facilitating emergence enhanced warming climate.

Language: Английский

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Significance of vertical transmission of arboviruses in mosquito-borne disease epidemiology

Parasites & Vectors, Journal Year: 2025, Volume and Issue: 18(1)

Published: April 9, 2025

Abstract Mosquito-borne diseases (MBDs) are increasingly prevalent due to the resultant impact of global change with significant health and economic impacts worldwide. Dengue virus (DENV), chikungunya (CHIKV), Zika (ZIKV), yellow fever (YFV), Japanese encephalitis (JEV), West Nile (WNV) transmitted by Aedes Culex species have been identified as arboviruses public interest. The vertical transmission (VT) refers process where infected mosquitoes transmit viruses their offspring; this has often overlooked in MBD epidemiology. We conducted a systematic review evaluate role VT occurrence, prevalence, spread MBDs, focusing on study types, mosquito species, genera. In total, 73 studies from 2005 2024 relating population were reviewed. Findings revealed occurrence across multiple natural experimental settings, variation rates depending vector genus, location. aegypti , albopictus vexans pipiens tarsalis quinquefasciatus that support VT, while pathogens be vertically DENV, ZIKV, WNV, CHIKV, YFV, Sindbis (SINV), Ross River (RRV), Mayaro (MAYV). reported minimum, infection rate (MIR) varied type Also, high may precede mosquito-borne disease outbreak. These findings indicate though overlooked, contributes dynamics could influence outbreaks endemism, especially under changing climatic conditions, highlighting need for incorporating mathematical models, studies, control strategies understand given its potential sustaining arbovirus influencing outbreak dynamics. Graphical abstract

Language: Английский

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Effects of temperature and humidity on the survival and hatching response of diapausing and non-diapausing Aedes aegypti eggs

Journal of Insect Physiology, Journal Year: 2024, Volume and Issue: 161, P. 104726 - 104726

Published: Dec. 3, 2024

Language: Английский

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Temperature-Driven Zika Virus Risk Prediction Model and Control Strategies: A Case Study of Brazil

Journal of Applied Mathematics and Physics, Journal Year: 2024, Volume and Issue: 12(12), P. 4213 - 4241

Published: Jan. 1, 2024

Language: Английский

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