Metal ion-crosslinking multifunctional hydrogel microspheres with inflammatory immune regulation for cartilage regeneration
Zhuoming Xu,
No information about this author
Jun Ma,
No information about this author
Hanyin Hu
No information about this author
et al.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: Jan. 28, 2025
Introduction
Osteoarthritis
(OA)
is
a
degenerative
disease
of
the
joints
characterized
by
cartilage
degradation
and
synovial
inflammation.
Due
to
complex
pathogenesis
OA,
multifaceted
therapies
that
modulate
inflammatory
immune
microenvironmental
disturbances
while
promoting
regeneration
are
key
control
progression
OA.
Methods
Herein,
multifunctional
nanoparticle
(DIC/Mg-PDA
NPs)
was
constructed
successfully
metal
chelation
effect
between
Mg
2+
catecholamine
bond
from
dopamine,
followed
amidation
with
diclofenac
(DIC),
which
then
prepared
into
an
injectable
hydrogel
microsphere
(DIC/Mg-PDA@HM)
immune-regulating
cartilage-repairing
abilities
through
microfluidic
technology
for
treatment
osteoarthritis.
Results
discussion
The
sustained
release
composite
microspheres
achieved
regulation
converting
macrophages
M1
M2
promoted
differentiation
BMSCs.
Moreover,
enhanced
DIC
polydopamine
(PDA)
effectively
downregulated
factors,
finally
OA
therapy.
In
addition,
in
vivo
MRI
tissue
section
staining
model
proved
significant
efficacy
on
conclusion,
these
novel
demonstrated
promising
prospect
multidisciplinary
repairing
Language: Английский
Effects of different acupuncture and moxibustion methods on knee joint cartilage morphology, serum inflammatory factors, and intestinal flora in rats with knee osteoarthritis
Journal of Acupuncture and Tuina Science,
Journal Year:
2025,
Volume and Issue:
23(1), P. 22 - 35
Published: Feb. 1, 2025
Language: Английский
Gut and Joint Microbiomes
Rheumatic Disease Clinics of North America,
Journal Year:
2025,
Volume and Issue:
51(2), P. 295 - 324
Published: March 6, 2025
Language: Английский
The Interaction Between Microbiota and Stem Cells on Progression of Osteoarthritis and Engineered Stem Cell for Enhancing Osteoarthritis Treatment
Sidan Wang,
No information about this author
Haotian Fu,
No information about this author
Zheng Xu
No information about this author
et al.
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 3219 - 3234
Published: March 1, 2025
Osteoarthritis
(OA)
is
characterized
by
the
degeneration
of
articular
cartilage
caused
several
factors
which
novel
most
trends
include
microbiota.
Specific
microbiota
and
role
in
development
OA
less
clear.
The
presumed
to
influence
occurrence
progression
mainly
via
immune
modulation.
In
recent
years,
bone
marrow
mesenchymal
stem
cells
(MSCs)
have
shown
great
potential
for
treatment
OA,
however,
therapeutic
efficiency
has
been
seriously
affected
harsh
microenvironment
joint
cavity.
At
present,
many
strategies
used
enhance
function
MSCs,
among
them,
engineering
are
a
promising
method.
Therefore,
this
review
focuses
on
latest
research
how
affects
cell
repair,
use
engineered
MSCs
OA.
addition,
can
exosomes
as
strategy
treating
Our
provides
comprehensive
perspective
therapy
Language: Английский
Qingjie Fuzheng Granule prevents colitis-associated colorectal cancer by inhibiting abnormal activation of NOD2/NF-κB signaling pathway mediated by gut microbiota disorder
Bin Huang,
No information about this author
Honglin An,
No information about this author
Mengxuan Gui
No information about this author
et al.
Chinese Herbal Medicines,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Language: Английский