The problem that residual Mycobacterium bovis infection poses for the eradication of bovine tuberculosis DOI
John Wiseman, Joseph P. Cassidy, Eamonn Gormley

et al.

The Veterinary Journal, Journal Year: 2024, Volume and Issue: 308, P. 106266 - 106266

Published: Nov. 9, 2024

Language: Английский

How macrophage heterogeneity affects tuberculosis disease and therapy DOI
David G. Russell, Nelson V. Simwela,

Joshua T. Mattila

et al.

Nature reviews. Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

6
Candidate transmission survival genome ofMycobacterium tuberculosis DOI Creative Commons
Saurabh Mishra, Prabhat Ranjan Singh, Xiaoyi Hu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Abstract Mycobacterium tuberculosis (Mtb), a leading cause of death from infection, completes its life cycle entirely in humans except for transmission through the air. To begin to understand how Mtb survives aerosolization, we mimicked liquid and atmospheric conditions experienced by before after exhalation using model aerosol fluid (MAF) based on water-soluble, lipidic cellular constituents necrotic lesions. MAF induced drug tolerance Mtb, remodeled transcriptome protected dying microdroplets desiccating Yet survival was not passive: appeared rely hundreds genes survive associated with transmission. Essential subserving proteostasis offered most protection. A large number conventionally nonessential contribute as well, including encoding proteins that resemble anti-desiccants. The candidate genome may offer opportunities reduce tuberculosis. Significance Statement (Mtb) travels lungs one person air another multiple stresses en route, changes temperature concentrations oxygen, carbon dioxide, hydrogen ions, salts organic solutes. Here present genetically tractable identification Mtb. We devised mimics TB lesions, found it protects transmission-related stresses, this structure droplets they dry their ability retain water, used query potential contribution each Mtb’s models three sequential stages

Language: Английский

Citations

0
Candidate transmission survival genome of Mycobacterium tuberculosis DOI Creative Commons
Saurabh Mishra, Prabhat Ranjan Singh, Xiaoyi Hu

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(10)

Published: March 7, 2025

Mycobacterium tuberculosis (Mtb), a leading cause of death from infection, completes its life cycle entirely in humans except for transmission through the air. To begin to understand how Mtb survives aerosolization, we mimicked liquid and atmospheric conditions experienced by before after exhalation using model aerosol fluid (MAF) based on water-soluble, lipidic, cellular constituents necrotic lesions. MAF induced drug tolerance Mtb, remodeled transcriptome, protected dying microdroplets desiccating Yet survival was not passive: appeared rely hundreds genes survive associated with transmission. Essential subserving proteostasis offered most protection. A large number conventionally nonessential contribute as well, including encoding proteins that resemble antidesiccants. The candidate genome may offer opportunities reduce tuberculosis.

Language: Английский

Citations

0
The health impact of identifying a person with tuberculosis through systematic screening DOI
Emily A. Kendall, David W. Dowdy

The Lancet Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
The problem that residual Mycobacterium bovis infection poses for the eradication of bovine tuberculosis DOI
John Wiseman, Joseph P. Cassidy, Eamonn Gormley

et al.

The Veterinary Journal, Journal Year: 2024, Volume and Issue: 308, P. 106266 - 106266

Published: Nov. 9, 2024

Language: Английский

Citations

1