Histone Phosphorylation in DNA Damage Response DOI Open Access
Ping Gong, Zhaohui Guo, Shengping Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2405 - 2405

Published: March 7, 2025

The DNA damage response (DDR) is crucial for maintaining genomic stability and preventing the accumulation of mutations that can lead to various diseases, including cancer. DDR a complex cellular regulatory network involves sensing, signal transduction, repair, cell cycle arrest. Modifications in histone phosphorylation play important roles these processes, facilitating repair factor recruitment, chromatin remodeling, regulation. precise regulation critical effective damage, integrity maintenance, prevention diseases such as cancer, where mechanisms are often compromised. Thus, understanding provides insights into offers potential therapeutic targets associated with instability, cancers.

Language: Английский

Histone Phosphorylation in DNA Damage Response DOI Open Access
Ping Gong, Zhaohui Guo, Shengping Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2405 - 2405

Published: March 7, 2025

The DNA damage response (DDR) is crucial for maintaining genomic stability and preventing the accumulation of mutations that can lead to various diseases, including cancer. DDR a complex cellular regulatory network involves sensing, signal transduction, repair, cell cycle arrest. Modifications in histone phosphorylation play important roles these processes, facilitating repair factor recruitment, chromatin remodeling, regulation. precise regulation critical effective damage, integrity maintenance, prevention diseases such as cancer, where mechanisms are often compromised. Thus, understanding provides insights into offers potential therapeutic targets associated with instability, cancers.

Language: Английский

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