Journal of Dispersion Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 32
Published: April 11, 2025
Language: Английский
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 136 - 136
Published: Jan. 19, 2025
Nanosuspensions (NS), with their submicron particle sizes and unique physicochemical properties, provide a versatile solution for enhancing the administration of medications that are not highly soluble in water or lipids. This review highlights recent advancements, future prospects, challenges NS-based drug delivery, particularly oral, ocular, transdermal, pulmonary, parenteral routes. The conversion oral NS into powders, pellets, granules, tablets, capsules, incorporation film dosage forms to address stability concerns is thoroughly reviewed. article summarizes key stabilizers, polymers, surfactants, excipients used formulations, along ongoing clinical trials patents. Furthermore, comprehensive analysis various methods preparation provided. also explores vitro vivo characterization techniques, as well scale-down technologies bottom-up preparation. Selected examples commercial products discussed. Rapid advances field could resolve issues related permeability-limited absorption hepatic first-pass metabolism, offering promise based on proteins peptides. evolution novel stabilizers essential overcome current limitations stability, bioavailability, targeting ability, safety profile, which ultimately accelerates application commercialization.
Language: Английский
Citations
3
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 102 - 102
Published: Jan. 14, 2025
The deposition of monosodium urate (MSU) crystals within joint spaces produces a painful inflammatory condition known as gout, specific form arthritis. calls for combined curative and preventive management model. A new development in the approach to gout is that NLRP3-targeted biologic agents, such monoclonal therapies, provide more accurate treatment by blocking pro-inflammatory cytokines. Nanoparticle drug delivery enhances biological availability targets, which may increase therapeutic efficacy decrease general toxicity. again cannot be ignored, mainly keeping up certain modifications diet weight, along with pharmacological therapies reduce uric acid (UA) levels frequency acute attacks. advancement genetic profiling patients biomarker discoveries drives trend towards building individualized medicine care, quickly gaining ground most effective method delivering treatments individual patients, moving away from one-size-fits-all treatments. following paper aims an updated account focus on recent developments, order enhance these approaches, quality life standard treatment.
Language: Английский
Citations
0
The AAPS Journal, Journal Year: 2025, Volume and Issue: 27(2)
Published: March 14, 2025
Language: Английский
Citations
0
ACS Omega, Journal Year: 2025, Volume and Issue: unknown
Published: March 18, 2025
This study systematically evaluated the effects of media milling on physicochemical properties, bioactive compound content, and functional applications fresh jujube (Ziziphus jujuba Mill.) juice. Optimization experiments identified ideal conditions for nanoparticle production, including 5% solid content a 180 min duration, resulting in significantly reduced particle sizes─volume-weighted average diameter (from 229.0 ± 1.0 to 25.0 0.2 μm) number-weighted 7.2 0.0 0.1 μm)─and improved dispersion stability. Media enhanced key properties such as zeta potential, viscosity, suspension stability, while also modifying color pH. The process notably increased compounds, total flavonoids 2.9 3.8 mg catechin equivalent (CE)/g dry weight (DW)) triterpenoids 15.4 1.2 28.0 4.9 oleanolic acid (OAE)/g DW). antioxidant activity before after milling, assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing power (FRAP), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays, remained comparable. Fermentation with Lactiplantibacillus plantarum demonstrated that both blended media-milled juice can serve effective substrates substrate utilization lactic production. Anti-inflammatory assays RAW 264.7 macrophages revealed nitric oxide production lower levels pro-inflammatory cytokines IL-1β, showcasing juice's potential modulate inflammation. In dextran sodium sulfate (DSS)-induced colitis mouse model, safety, though it did not show significant protective effects. These findings position promising food ingredient health promotion disease management.
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 485 - 485
Published: April 7, 2025
Background: D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), an amphiphilic derivative of natural vitamin E, functions as both a drug efflux inhibitor and protector against enzymatic degradation has been widely incorporated into nano-formulations for design delivery. Objective: This systematic review evaluates TPGS-based organic nanocarriers, emphasizing their potential to enhance bioavailability active compounds which include drugs phytochemicals, improve pharmacokinetic profiles, optimize therapeutic outcomes, eventually overcoming the limitations conventional oral Search strategy: Data collection was carried out by entering key terms (TPGS) AND (Micelle OR Liposome Nanoparticle Nanotube Dendrimer Niosome Nanosuspension Nanomicelle Nanocrystal Nanosphere Nanocapsule) (Oral Bioavailability) Scopus database. Inclusion criteria: Full-text articles published in English relevant TPGS, featured materials, utilized administration route, included study, were final review. extraction analysis: selection conducted two authors subsequently approved all other through consensus process. The outcomes studies reviewed categorized based on types nanocarriers. Results: An initial search database yielded 173 records. After screening title abstract, 52 full-text analyzed. A total 21 papers excluded while 31 used this Conclusions: concludes that nanocarriers are able various compounds, including several leveraging TPGS’s nature, inhibition transporters, protection degradation, stabilization properties. Despite using same excipient, variability particle size, zeta potential, encapsulation efficiency among indicates need tailored formulations. comprehensive approach involving development standardized comparison diverse TPGS-incorporated compound formulations is essential identify optimal nanocarrier improving particular compound’s bioavailability.
Language: Английский
Citations
0
Journal of Dispersion Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 32
Published: April 11, 2025
Language: Английский
Citations
0