Comparative Analysis of Oral Prevotella intermedia, Tannerella forsythia, Streptococcus sanguinis, and Streptococcus mutans in Patients with Esophageal Squamous Cell Carcinoma and Healthy Controls in Mthatha, South Africa

Bacteria, Journal Year: 2025, Volume and Issue: 4(1), P. 11 - 11

Published: March 1, 2025

The microbiome plays a crucial role in cancer development, influencing fundamental processes such as cell proliferation, apoptosis, immune system regulation, and host metabolism. Recent studies have highlighted possible relationship between esophageal the oral microbiota, making microflora risk factor. bacteria Prevotella intermedia, Tannerella forsythia, Streptococcus sanguinis, mutans, implicated various pathologies, were of interest this study, which was initiated to examine their potential etiology squamous carcinoma (ESCC). To achieve this, case-control design used, with whole saliva samples collected from 24 healthy controls patients carcinoma. DNA then extracted, real-time PCR performed quantify presence targeted both groups. results showed that all studied present ESCC controls. However, expression levels significantly higher ESCC. Specifically, marked increase P. T. S. mutans observed compared In short, study highlights significant imbalance microbial flora, an increased abundance selected monitoring these could thus be exploited track who are at risk. Their integration into diagnostic therapeutic strategies would offer new prospects for early diagnosis improved prognosis

Language: Английский

Advances in Non-Invasive Screening Methods for Gastrointestinal Cancers: How Continued Innovation Has Revolutionized Early Cancer Detection

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1085 - 1085

Published: March 24, 2025

The early diagnosis of gastrointestinal cancers is essential for better survival and to reduce the burden malignancies worldwide [...].

Language: Английский