SARS-CoV-2 neutralizing antibody specificities differ dramatically between recently infected infants and immune-imprinted individuals DOI Creative Commons
Bernadeta Dadonaite, Allison Burrell,

Jenni Logue

et al.

Journal of Virology, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

ABSTRACT The immune response to viral infection is shaped by past exposures related virus strains, a phenomenon known as imprinting. For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), much of the population has been imprinted spike from an early strain, either through vaccination or during stages COVID-19 pandemic. As consequence this imprinting, with more recent SARS-CoV-2 strains primarily boosts cross-reactive antibodies elicited imprinting strain. Here we compare neutralizing antibody specificities individuals versus infants infected Specifically, use pseudovirus-based deep mutational scanning measure how mutations affect neutralization serum adults and children original vaccine primary XBB* variant. While activity targets receptor-binding domain (RBD), only mostly N-terminal domain. In these infants, secondary exposure via shifts toward RBD, although specific RBD sites targeted are different adults. dramatic differences in among histories likely impact evolution. IMPORTANCE We show that person’s history strongly affects which regions on their target. particular, who have just once strain make target than exposed both older strains. This person-to-person heterogeneity means same mutation can impacts immunity people.

Language: Английский

SARS-CoV-2 neutralizing antibody specificities differ dramatically between recently infected infants and immune-imprinted individuals DOI Creative Commons
Bernadeta Dadonaite, Allison Burrell,

Jenni Logue

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

The immune response to viral infection is shaped by past exposures related virus strains, a phenomenon known as imprinting. For SARS-CoV-2, much of the population has been imprinted spike from an early strain, either through vaccination or during stages COVID-19 pandemic. As consequence this imprinting, with more recent SARS-CoV-2 strains primarily boosts cross-reactive antibodies elicited imprinting strain. Here we compare neutralizing antibody specificities individuals versus infants infected Specifically, use pseudovirus-based deep mutational scanning measure how mutations affect neutralization serum adults and children original vaccine primary XBB* variant. While activity targets receptor-binding domain (RBD), only mostly N-terminal (NTD). In these infants, secondary exposure via shifts towards RBD, although specific RBD sites targeted are different than for adults. dramatic differences in among histories likely impact evolution.

Language: Английский

Citations

0
SARS-CoV-2 neutralizing antibody specificities differ dramatically between recently infected infants and immune-imprinted individuals DOI Creative Commons
Bernadeta Dadonaite, Allison Burrell,

Jenni Logue

et al.

Journal of Virology, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

ABSTRACT The immune response to viral infection is shaped by past exposures related virus strains, a phenomenon known as imprinting. For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), much of the population has been imprinted spike from an early strain, either through vaccination or during stages COVID-19 pandemic. As consequence this imprinting, with more recent SARS-CoV-2 strains primarily boosts cross-reactive antibodies elicited imprinting strain. Here we compare neutralizing antibody specificities individuals versus infants infected Specifically, use pseudovirus-based deep mutational scanning measure how mutations affect neutralization serum adults and children original vaccine primary XBB* variant. While activity targets receptor-binding domain (RBD), only mostly N-terminal domain. In these infants, secondary exposure via shifts toward RBD, although specific RBD sites targeted are different adults. dramatic differences in among histories likely impact evolution. IMPORTANCE We show that person’s history strongly affects which regions on their target. particular, who have just once strain make target than exposed both older strains. This person-to-person heterogeneity means same mutation can impacts immunity people.

Language: Английский

Citations

0