Conserved chromatin regulators control the transcriptional immune response to intracellular pathogens in Caenorhabditis elegans DOI Creative Commons
Eillen Tecle,

Paaramitha Warushavithana,

Samuel Li

et al.

PLoS Genetics, Journal Year: 2025, Volume and Issue: 21(4), P. e1011444 - e1011444

Published: April 7, 2025

Robust transcriptional responses are critical for defense against infection. However, unrestrained immune can cause negative impacts such as damaging inflammation and slowed development. Here, we find that a class of regulators previously associated with regulation development in Caenorhabditis elegans , is also involved repressing responses. Specifically, through forward genetics, loss lin-15B leads to constitutive expression Intracellular Pathogen Response (IPR) genes. encodes repressor conserved THAP domain the DRM chromatin remodeling complex regulates C. We show mutants have increased resistance natural intracellular pathogens, induction IPR genes relies on MES-4 histone methyltransferase. extend our analyses other NuRD factors, well SUMOylation modifiers, showing broad range chromatin-related factors repress gene expression. Altogether these findings suggest may facilitate part by pathogens.

Language: Английский

Conserved chromatin regulators control the transcriptional immune response to intracellular pathogens in Caenorhabditis elegans DOI Creative Commons
Eillen Tecle,

Paaramitha Warushavithana,

Samuel Li

et al.

PLoS Genetics, Journal Year: 2025, Volume and Issue: 21(4), P. e1011444 - e1011444

Published: April 7, 2025

Robust transcriptional responses are critical for defense against infection. However, unrestrained immune can cause negative impacts such as damaging inflammation and slowed development. Here, we find that a class of regulators previously associated with regulation development in Caenorhabditis elegans , is also involved repressing responses. Specifically, through forward genetics, loss lin-15B leads to constitutive expression Intracellular Pathogen Response (IPR) genes. encodes repressor conserved THAP domain the DRM chromatin remodeling complex regulates C. We show mutants have increased resistance natural intracellular pathogens, induction IPR genes relies on MES-4 histone methyltransferase. extend our analyses other NuRD factors, well SUMOylation modifiers, showing broad range chromatin-related factors repress gene expression. Altogether these findings suggest may facilitate part by pathogens.

Language: Английский

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