Cancers,
Journal Year:
2020,
Volume and Issue:
12(7), P. 1748 - 1748
Published: July 1, 2020
The
immune
system
is
a
crucial
regulator
of
tumor
biology
with
the
capacity
to
support
or
inhibit
cancer
development,
growth,
invasion
and
metastasis.
Emerging
evidence
show
that
reactive
oxygen
species
(ROS)
are
not
only
mediators
oxidative
stress
but
also
players
regulation
in
development.
This
review
intends
discuss
mechanism
by
which
ROS
can
affect
anti-tumor
response,
particular
emphasis
on
their
role
antigenicity,
immunogenicity
shaping
microenvironment.
Given
complex
play
dynamics
cancer-immune
cell
interaction,
further
investigation
needed
for
development
effective
strategies
combining
manipulation
immunotherapies
treatment.
Trends in Immunology,
Journal Year:
2023,
Volume and Issue:
44(3), P. 231 - 244
Published: Feb. 9, 2023
T
cell
subsets
adapt
and
rewire
their
metabolism
according
to
functions
surrounding
microenvironment.
Whereas
naive
cells
rely
on
mitochondrial
metabolic
pathways
characterized
by
low
nutrient
requirements,
effector
induce
kinetically
faster
generate
the
biomass
energy
needed
for
proliferation
cytokine
production.
Recent
findings
support
concept
that
alterations
in
also
affect
epigenetics
of
cells.
In
this
review
we
discuss
connections
between
epigenetic
changes
such
as
histone
post-translational
modifications
(PTMs)
DNA
methylation,
well
'extra-metabolic'
roles
enzymes
molecules.
These
collectively
point
a
new
group
potential
therapeutic
targets
treatment
cell-dependent
autoimmune
diseases
cancers.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: March 11, 2024
Abstract
The
ability
of
CD8
+
T
cells
to
infiltrate
solid
tumors
and
reach
cancer
is
associated
with
improved
patient
survival
responses
immunotherapy.
Thus,
identifying
the
factors
controlling
cell
migration
in
critical,
so
that
strategies
intervene
on
these
targets
can
be
developed.
Although
interstitial
motility
a
highly
energy-demanding
process,
metabolic
requirements
migrating
3D
environment
remain
unclear.
Here,
we
demonstrate
tricarboxylic
acid
(TCA)
cycle
main
pathway
sustaining
human
collagen
gels
tumor
slices
while
glycolysis
plays
more
minor
role.
Using
pharmacological
genetic
approaches,
report
depends
mitochondrial
oxidation
glucose
glutamine,
but
not
fatty
acids,
both
ATP
ROS
produced
by
mitochondria
are
required
for
migrate.
Pharmacological
interventions
increase
activity
improve
intratumoral
CAR
recruitment
into
islets
leading
better
control
growth
xenograft
models.
Our
study
highlights
rationale
targeting
metabolism
enhance
antitumor
efficacy
treating
tumors.
Autoimmune Diseases,
Journal Year:
2020,
Volume and Issue:
2020, P. 1 - 14
Published: June 25, 2020
Multiple
roles
have
been
indicated
for
reactive
oxygen
species
(ROS)
in
the
immune
system
recent
years.
ROS
extensively
studied
due
to
their
ability
damage
DNA
and
other
subcellular
structures.
Noticeably,
they
identified
as
a
pivotal
second
messenger
T-cell
receptor
signaling
activation
participate
antigen
cross-presentation
chemotaxis.
As
an
agent
with
direct
toxic
effects
on
cells,
lead
initiation
of
autoimmune
response.
Moreover,
levels
are
regulated
by
antioxidant
systems,
which
include
enzymatic
nonenzymatic
antioxidants.
Enzymatic
antioxidants
superoxide
dismutase,
catalase,
glutathione
peroxidase,
reductase.
Nonenzymatic
contain
vitamins
C,
A,
E,
glutathione,
thioredoxin.
Particularly,
cellular
systems
important
functions
maintaining
redox
homeostasis.
This
review
will
discuss
significant
generation
under
normal
conditions,
system,
pathogenesis
multiple
sclerosis.
Cancers,
Journal Year:
2020,
Volume and Issue:
12(7), P. 1748 - 1748
Published: July 1, 2020
The
immune
system
is
a
crucial
regulator
of
tumor
biology
with
the
capacity
to
support
or
inhibit
cancer
development,
growth,
invasion
and
metastasis.
Emerging
evidence
show
that
reactive
oxygen
species
(ROS)
are
not
only
mediators
oxidative
stress
but
also
players
regulation
in
development.
This
review
intends
discuss
mechanism
by
which
ROS
can
affect
anti-tumor
response,
particular
emphasis
on
their
role
antigenicity,
immunogenicity
shaping
microenvironment.
Given
complex
play
dynamics
cancer-immune
cell
interaction,
further
investigation
needed
for
development
effective
strategies
combining
manipulation
immunotherapies
treatment.
