Nurturing development: how a mother's nutrition shapes offspring's brain through the gut DOI
Mara Ioana Ionescu,

Carmen Denise Mihaela Zahiu,

Adelina Vlad

et al.

Nutritional Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: May 23, 2024

Pregnancy is a transformative period marked by profound physical and emotional changes, with far-reaching consequences for both mother child. Emerging research has illustrated the pivotal role of mother's diet during pregnancy in influencing prenatal gut microbiome subsequently shaping neurodevelopment her offspring. The intricate interplay between maternal health, nutrition, neurodevelopmental outcomes emerged as captivating field investigation within developmental science. Acting dynamic bridge fetus, microbiome, directly indirectly, impacts offspring's through diverse pathways. This comprehensive review delves into spectrum studies, clarifying putative mechanisms which modulating microbiota, orchestrates early stages brain development. Drawing insights from animal models human cohorts, this work underscores implications health trajectories offers glimpse formulation targeted interventions able to optimize prospect tailored dietary recommendations expectant mothers emerges promising accessible intervention foster growth beneficial bacteria, potentially leading enhanced cognitive reduced risks disorders.

Language: Английский

Modern Biomarkers for Autism Spectrum Disorder: Future Directions DOI Creative Commons
Amanda Jensen,

Alison L. Lane,

Brianna A. Werner

et al.

Molecular Diagnosis & Therapy, Journal Year: 2022, Volume and Issue: 26(5), P. 483 - 495

Published: June 27, 2022

Autism spectrum disorder is an increasingly prevalent neurodevelopmental in the world today, with estimated 2% of population being affected USA. A major complicating factor diagnosing, treating, and understanding autism that defining solely based on observation behavior. Thus, recent research has focused identifying specific biological abnormalities can provide clues to diagnosis treatment. Biomarkers are objective way identify measure for diagnostic purposes as well changes resulting from This current opinion paper discusses state various biomarkers currently development disorder. The types identified include prenatal history, genetics, neurological including neuroimaging, neurophysiologic, visual attention, metabolic mitochondrial, folate, trans-methylation, trans-sulfuration pathways, immune autoantibodies cytokine dysregulation, autonomic nervous system, nutritional. Many these have promising preliminary evidence post-natal pre-symptomatic risk assessment, confirmation diagnosis, subtyping, treatment response. However, most not undergone validation studies do investigate clinically relevant comparison groups. Although field biomarker promising, it appears early stages development.

Language: Английский

Citations

57
Microbiota-immune-brain interactions: A lifespan perspective DOI Creative Commons
Anna Ratsika,

Joana S. Cruz Pereira,

Caoimhe M.K. Lynch

et al.

Current Opinion in Neurobiology, Journal Year: 2022, Volume and Issue: 78, P. 102652 - 102652

Published: Dec. 1, 2022

There is growing appreciation of key roles the gut microbiota in maintaining homeostasis and influencing brain behaviour at critical windows across lifespan. Mounting evidence suggests that communication between could be to understanding multiple neuropsychiatric disorders, with immune system coming forefront as an important mechanistic mediator. Throughout lifespan, exchanges continuous reciprocal signals central nervous system. Intestinal microbial cues alter mediators consequences for host neurophysiology behaviour. Several factors challenge composition, which response release molecules neuro- immuno-active potential are crucial adequate neuro-immune interactions. In this review, contributing upkeep fine balance health disease these systems discussed, we elucidate implications inputs on

Language: Английский

Citations

54
Maternal immune activation and role of placenta in the prenatal programming of neurodevelopmental disorders DOI Creative Commons
Rebecca M. Woods, Jarred M. Lorusso, Jennifer Fletcher

et al.

Neuronal Signaling, Journal Year: 2023, Volume and Issue: 7(2)

Published: May 17, 2023

Maternal infection during pregnancy, leading to maternal immune activation (mIA) and cytokine release, increases the offspring risk of developing a variety neurodevelopmental disorders (NDDs), including schizophrenia. Animal models have provided evidence support these mechanistic links, with placental inflammatory responses dysregulation function implicated. This leads changes in fetal brain balance altered epigenetic regulation key pathways. The prenatal timing such mIA-evoked changes, accompanying developmental an

Language: Английский

Citations

27
Between Dysbiosis, Maternal Immune Activation and Autism: Is There a Common Pathway? DOI Open Access
Maria Suprunowicz,

Natalia Tomaszek,

Agata Urbaniak

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(4), P. 549 - 549

Published: Feb. 16, 2024

Autism spectrum disorder (ASD) is a neuropsychiatric condition characterized by impaired social interactions and repetitive stereotyped behaviors. Growing evidence highlights an important role of the gut–brain–microbiome axis in pathogenesis ASD. Research indicates abnormal composition gut microbiome potential involvement bacterial molecules neuroinflammation brain development disruptions. Concurrently, attention directed towards short-chain fatty acids (SCFAs) intestinal tightness. This comprehensive review emphasizes impact maternal microbiota changes on autism children, especially considering immune activation (MIA). The following paper evaluates birth route colonization child with bacteria first weeks life. Furthermore, it explores pro-inflammatory cytokines, such as IL-6 IL-17a mother’s obesity potentially environmental factors purpose this to advance our understanding ASD pathogenesis, while also searching for positive implications latest therapies, probiotics, prebiotics or fecal transplantation, targeting reducing inflammation. aims provide valuable insights that could instruct future studies treatments individuals affected

Language: Английский

Citations

14
Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders DOI
Eunha Kim, Jun R. Huh, Gloria B. Choi

et al.

Nature Immunology, Journal Year: 2024, Volume and Issue: 25(4), P. 598 - 606

Published: April 1, 2024

Language: Английский

Citations

14
Immune drivers of physiological and pathological pain DOI Creative Commons
Aakanksha Jain, Sara Hakim, Clifford J. Woolf

et al.

The Journal of Experimental Medicine, Journal Year: 2024, Volume and Issue: 221(5)

Published: April 12, 2024

Physiological pain serves as a warning of exposure to danger and prompts us withdraw from noxious stimuli prevent tissue damage. Pain can also alert an infection or organ dysfunction aids in locating such malfunction. However, there are instances where is purely pathological, unresolved following inflammation injury the nervous system, this be debilitating persistent. We now appreciate that immune cells integral both physiological pathological pain, consequence, not strictly neuronal phenomenon. Here, we discuss recent findings on how skin, nerve, dorsal root ganglia, spinal cord interact with somatosensory neurons mediate pain. innate adaptive cells, by releasing various ligands mediators, contribute initiation, modulation, persistence, resolution modalities Finally, propose neuroimmune axis attractive target for treatment, but challenges objectively quantifying preclinically, variable sex differences presentation, well adverse outcomes associated system all need considered development immunotherapies against

Language: Английский

Citations

14
Prenatal exposure to maternal disadvantage-related inflammatory biomarkers: associations with neonatal white matter microstructure DOI Creative Commons
Ashley Sanders, Brian Tirado, Nicole A. Seider

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 2, 2024

Abstract Prenatal exposure to heightened maternal inflammation has been associated with adverse neurodevelopmental outcomes, including atypical brain maturation and psychiatric illness. In mothers experiencing socioeconomic disadvantage, immune activation can be a product of the chronic stress inherent such environmental hardship. While growing preclinical clinical evidence shown links between altered neonatal development increased inflammatory states in utero, potential mechanism by which disadvantage differentially impacts neural-immune crosstalk remains unclear. current study, we investigated associations gestational inflammation, white matter microstructure 320 mother-infant dyads over-sampled for poverty. We analyzed serum levels four cytokines (IL-6, IL-8, IL-10, TNF-α) over course pregnancy relation offspring disadvantage. Higher average IL-6 was very low status (SES; INR < 200% poverty line) lower corticospinal fractional anisotropy (FA) uncinate axial diffusivity (AD). No other cytokine SES. IL-10 FA higher radial (RD) corpus callosum tracts, optic radiation RD, AD, inferior fronto-occipital fasciculus anterior limb internal capsule tracts. SES moderated relationship TNF-α during gestation diffusivity. When these interactions were decomposed, patterns indicated that this association significant positive among neonates, whereby inversely significantly cingulum AD. By contrast, more advantaged neonates (lower-to-higher [INR ≥ line]), positively superior Taken together, findings suggest prenatal differs as function These are consistent scenario where inflammation’s effects on diverge depending availability foundational resources utero.

Language: Английский

Citations

11
Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB DOI

Yunjin Lee,

Tomoe Ishikawa, Hyeseung Lee

et al.

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

1
At the crux of maternal immune activation: Viruses, microglia, microbes, and IL‐17A DOI Creative Commons

Ashley Otero,

Adrienne M. Antonson

Immunological Reviews, Journal Year: 2022, Volume and Issue: 311(1), P. 205 - 223

Published: Aug. 18, 2022

Summary Inflammation during prenatal development can be detrimental to neurodevelopmental processes, increasing the risk of neuropsychiatric disorders. Prenatal exposure maternal viral infection pregnancy is a leading environmental factor for manifestation these Preclinical animal models immune activation (MIA), established investigate this link, have revealed common and microbial signaling pathways that link mother fetus set tone neurodevelopment. In particular, intestinal T helper 17 cells, educated by endogenous microbes, appear key drivers effector IL‐17A signals capable reaching fetal brain causing neuropathologies. Fetal microglial cells are particularly sensitive maternally derived inflammatory signals, they shift their functional phenotype in response MIA. Resulting cortical malformations miswired interneuron circuits cause aberrant offspring behaviors recapitulate core symptoms human Still, popular use “sterile” immunostimulants initiate MIA has limited translation clinic, as stimulants fail capture biologically relevant innate adaptive sequelae induced live pathogen infection. Thus, there need more translatable models, with focus on pathogens like seasonal influenza viruses.

Language: Английский

Citations

21
The multifaceted roles of embryonic microglia in the developing brain DOI Creative Commons
Yuki Hattori

Frontiers in Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: May 12, 2023

Microglia are the resident immune cells of central nervous system (CNS). originate from erythromyeloid progenitors in yolk sac at early embryonic stage, and these then colonize CNS through extensive migration proliferation during development. account for 10% all adult brain, whereas proportion brain is only 0.5–1.0%. Nevertheless, microglia developing widely move their cell body within structure by extending filopodia; thus, they can interact with surrounding cells, such as neural lineage vascular-structure-composing cells. This active microglial motility suggests that play a pivotal role Indeed, recent increasing evidence has revealed diverse functions stage. For example, control differentiation stem regulate population size modulate positioning function neurons. Moreover, exert not on but also blood vessels, supporting vascular formation integrity. review summarizes advances understanding cellular dynamics multifaceted particular focus discusses fundamental molecular mechanisms underlying behavior.

Language: Английский

Citations

12