Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 24, 2025
Interferon-Induced
Protein
with
Tetratricopeptide
Repeats
3
(IFIT3)
plays
a
dual
role
in
innate
immunity
and
tumor
immunity,
functioning
as
both
viral
defense
molecule
regulator
of
progression.
This
review
explores
the
mechanisms
through
which
IFIT3
modulates
immune
responses,
including
interferon
signaling,
RIG-I-like
receptors,
NF-κB
pathway.
facilitates
evasion
promotes
inflammation-mediated
growth
by
regulating
checkpoints
microenvironment,
its
emerging
target
for
cancer
immunotherapy
opens
new
avenues
therapeutic
strategies.
Finally,
this
paper
underscores
IFIT3's
potential
clinical
applications
modulation
highlighting
need
further
research
on
IFIT3-targeted
therapies.
Cancer Medicine,
Journal Year:
2025,
Volume and Issue:
14(3)
Published: Feb. 1, 2025
ABSTRACT
Background
Lung
cancer
is
among
the
most
common
and
deadliest
malignant
tumors
worldwide.
It
often
detected
at
late
stages,
resulting
in
unfavorable
outcomes,
with
tumor
cell
heterogeneity
medication
resistance.
Tumor‐associated
macrophages
are
key
cells
contributing
to
progression.
They
categorized
into
two
primary
phenotypes:
Proinflammatory
(M1)
anti‐inflammatory
(M2)
which
involved
onset
progression
of
NSCLC.
The
role
cytokines
secreted
by
lung
described,
effects
various
substances
such
as
RNA
or
protein
on
differentiation
polarization
phenotypes
highlighted
characterize
impact
immune
state
therapeutic
effect
treatments
patient
prognosis.
Researchers
have
primarily
aimed
investigate
innovative
carriers
strategies
based
modify
microenvironment.
Objectives
These
approaches
integrated
other
treatments,
particularly
immunotherapy,
enhance
efficacy.
Methods
A
comprehensive
review
was
carried
out
systematically
synthesizing
existing
literature
PubMed,
using
combination
keywords
“TAMs”,
“NSCLC”,
“Drug
resistance”,
“therapy”.
available
studies
were
screened
for
selection
quality
relevance.
Conclusions
TAMs
promote
invasion,
growth,
metastasis
promoting
angiogenesis
EMT.
In
addition,
they
contribute
development
drug
resistance
immunosuppressive
microenvironment
establishment.
factors
TAM
can
weaken
activity
cells,
inhibit
their
killing
tumors,
leading
suppression
hindering
effectiveness
treatment.
Therefore,
a
target
immunotherapy.
Various
being
explored,
including
reducing
recruitment
influencing
treat
treatment
systems
achieve
precise
delivery
drugs
gene
interfering
molecules
without
causing
side
effects.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 24, 2025
Interferon-Induced
Protein
with
Tetratricopeptide
Repeats
3
(IFIT3)
plays
a
dual
role
in
innate
immunity
and
tumor
immunity,
functioning
as
both
viral
defense
molecule
regulator
of
progression.
This
review
explores
the
mechanisms
through
which
IFIT3
modulates
immune
responses,
including
interferon
signaling,
RIG-I-like
receptors,
NF-κB
pathway.
facilitates
evasion
promotes
inflammation-mediated
growth
by
regulating
checkpoints
microenvironment,
its
emerging
target
for
cancer
immunotherapy
opens
new
avenues
therapeutic
strategies.
Finally,
this
paper
underscores
IFIT3's
potential
clinical
applications
modulation
highlighting
need
further
research
on
IFIT3-targeted
therapies.
