From Genesis to Old Age: Exploring the Immune System One Cell at a Time with Flow Cytometry DOI Creative Commons
Anis Larbi

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1469 - 1469

Published: July 3, 2024

The immune system is a highly complex and tightly regulated that plays crucial role in protecting the body against external threats, such as pathogens, internal abnormalities, like cancer cells. It undergoes development during fetal stages continuously learns from each encounter with allowing it to develop immunological memory provide wide range of protection. Over time, after numerous encounters years functioning, can begin show signs erosion, which commonly named immunosenescence. In this review, we aim explore how responds initial antigens handles persistent stimulations throughout person's lifetime. Our understanding has greatly benefited advanced technologies flow cytometry. context, will discuss valuable contribution cytometry enhancing our knowledge behavior aging, specific focus on T-cells. Moreover, expand discussion cytometry-based assessment extracellular vesicles, recently discovered communication channel biology, their implications for functioning.

Language: Английский

T Cell Development: From T-Lineage Specification to Intrathymic Maturation DOI
Mahdieh Golzari-Sorkheh,

Kogulan Yoganathan,

Edward L.Y. Chen

et al.

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 81 - 137

Published: Jan. 1, 2025

Language: Английский

Citations

0

From Genesis to Old Age: Exploring the Immune System One Cell at a Time with Flow Cytometry DOI Creative Commons
Anis Larbi

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1469 - 1469

Published: July 3, 2024

The immune system is a highly complex and tightly regulated that plays crucial role in protecting the body against external threats, such as pathogens, internal abnormalities, like cancer cells. It undergoes development during fetal stages continuously learns from each encounter with allowing it to develop immunological memory provide wide range of protection. Over time, after numerous encounters years functioning, can begin show signs erosion, which commonly named immunosenescence. In this review, we aim explore how responds initial antigens handles persistent stimulations throughout person's lifetime. Our understanding has greatly benefited advanced technologies flow cytometry. context, will discuss valuable contribution cytometry enhancing our knowledge behavior aging, specific focus on T-cells. Moreover, expand discussion cytometry-based assessment extracellular vesicles, recently discovered communication channel biology, their implications for functioning.

Language: Английский

Citations

0