Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 28, 2025
Conventional dendritic cells (cDCs) are crucial antigen-presenting that initiate and regulate T cell responses, thereby shaping immunity against pathogens, innocuous antigens, tumors, self-antigens. The migration of cDCs from peripheral tissues to draining lymph nodes (dLNs) is essential for their function in immune surveillance. This allows convey the conditions antigen-specific dLNs, facilitating effective responses. Migration primarily mediated by chemokine receptor CCR7, which upregulated response homeostatic inflammatory cues, guiding dLNs. However, during type 2 such as those triggered parasites or allergens, a paradox arises—cDCs exhibit robust dLNs despite low CCR7 expression. review discusses how inflammation relies on additional signaling pathways, including induced membrane-derived bioactive lipid mediators like eicosanoids, sphingolipids, oxysterols, cooperate with enhance cDC helper (Th2) differentiation. We explore potential regulatory mechanisms immunity, offering insights into differential control trafficking diverse contexts its impact
Language: Английский