Metabolic syndrome

Nature Reviews Disease Primers, Journal Year: 2024, Volume and Issue: 10(1)

Published: Oct. 17, 2024

Language: Английский

---

Longitudinal economic burden of incident complications among metabolic syndrome populations

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 10, 2024

Abstract Background This study quantifies the longitudinal economic burden for a wide spectrum of incident complications, metabolic syndrome (MS)-related risk factors, and comorbidities in patients with MS. Methods retrospective utilized linked data from 2013 National Health Interview Survey 2012–2021 Insurance Research Database to identify MS individuals their characteristics. The incidence rate each complication was calculated as number events period divided by total person-years during follow-up. healthcare costs complications were analyzed using generalized estimating equation model determine cost impact after adjustment patients’ Sensitivity analyses on variables high missing rates (i.e., cause death, body mass index) performed. Results Among 837 identified over 8.28 (± 1.35) years follow-up, most frequent microvascular diseases (incidence nephropathy/retinopathy/neuropathy: 6.49/2.64/2.08 per 100 person-years), followed cardiovascular (2.47), peripheral vascular (2.01), cancers (1.53). Death costliest event (event-year person: USD 16,429) expensive (USD 9,127−11,083 non-MS- MS-related cancers). Developing non-MS/MS-related cancers, diseases, obesity-related medical conditions increased annual 273% (95% CI: 181−397%)/175% (105−269%), 159% (118−207%), 140% (84−214%), respectively. Microvascular had lowest 27% [17−39%]/27% [11−46%]/24% [11−37%] increases nephropathy/neuropathy/retinopathy, respectively). Having existing 20% (osteoarthritis) 108% (depression). morbid obesity index ≥ 35 kg/m 2 ) 58% (30−91%). Conclusions costly cancers), factors obesity), depression) highlight urgent need early intervention prevent its progression. comprehensive estimates reported this can facilitate parameterization cost-effective interventions these patients.

Language: Английский

---

Combined effects of smoking and alcohol consumption on the risk of liver cancer according to metabolic syndrome: A nested case–control study in South Korea

International Journal of Cancer, Journal Year: 2024, Volume and Issue: 155(4), P. 654 - 665

Published: March 27, 2024

Abstract Tobacco and alcohol may interact to increase the risk of liver cancer, which might be modified by other factors. Their combined effects in context metabolic syndrome (MetS) remain unclear. Given increasing prevalence MetS, this nested case–control study was conducted evaluate smoking consumption on cancer with stratification MetS. We included 15,352 patients 92,112 matched controls who attended nationwide general health examination during 2009–2019, using a customized database ( N = 5,545,835) from Korean National Health Insurance Service. Liver according estimated conditional multivariable logistic regression. Additive multiplicative interactions between these two factors were assessed. Results showed that men, dual current users at significantly higher compared nonusers, adjusted odds ratio (aOR) 1.61, 95% confidence interval: (1.50, 1.72). Interactions detected light‐to‐moderate (0.1–28 g/day) heavy (>20 pack‐years) additive scale, relative excess due interaction 0.34 (0.16, 0.51), attributable proportion 0.22 (0.11, 0.33), synergy index 2.75 (1.85, 3.66), aOR for product term 1.28 (1.11, 1.49). An also revealed drinking MetS subgroup. In women, drinking/nonsmoking negatively associated non‐MetS conclusion, holistic promotion program should target male tobacco cigarettes alcohol, including users, especially those

Language: Английский

---

Prediction of metabolic syndrome using machine learning approaches based on genetic and nutritional factors: a 14-year prospective-based cohort study

BMC Medical Genomics, Journal Year: 2024, Volume and Issue: 17(1)

Published: Sept. 4, 2024

Language: Английский

---

The Longitudinal Effect of Sugar-Sweetened Beverage Consumption and Risk of All-Cause and Cause-Specific Mortality in Korean Adults: Results From the Health Examinees Study

Journal of the American Nutrition Association, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: Jan. 21, 2025

Objective High consumption of sugar-sweetened beverages (SSBs) is associated with an increased risk all-cause and cardiovascular disease (CVD) mortality; however, the data results for Asian populations, particularly in Korea, are limited unclear. Therefore, this research aimed to investigate association between types SSB cause-specific mortality South Korean adults.

Language: Английский

---

The Potential Effect of Periodontal Disease on the Development of Metabolic Syndrome: A 10‐Year Observational Study in a Thai Adult Cohort

Journal Of Clinical Periodontology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

ABSTRACT Aim As data are sparse on the long‐term association between periodontal diseases and development of metabolic syndrome (MetS), we investigated their relationship in a Thai cohort over 10‐year observational period. Methods Medical records assessments 2161 employees Electricity Generating Authority Thailand collected at two time points, 2003 2013, were used. Experienced periodontists used standard national international criteria to define periodontitis MetS. The impact baseline subsequent MetS incidence its components was evaluated using regression analyses. Results severity extent significantly predicted decade, with higher individuals poorer health. A single percentage increase raised risk by 0.4% developing individual 0.2%. Independent health, age an emerged as factor impacting development. Conclusion This study highlights potential effect increased progression Hyperglycaemia hypertension most affected existence periodontitis.

Language: Английский

---

Predictive Diagnostic Power of Anthropometric Indicators for Metabolic Syndrome: A Comparative Study in Korean Adults

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 448 - 448

Published: Jan. 12, 2025

Background/Objectives: Metabolic syndrome (MetS) is a cluster of risk factors that significantly increase the cardiovascular disease, including type 2 diabetes, etc. Assessing predictive diagnostic power anthropometric indicators for MetS crucial early identification and prevention related health issues. This study focuses on Korean adult population while providing insights may be applicable to broader global contexts. Therefore, this aimed compare capabilities various indicators, body mass index (BMI), waist-to-height ratio (WHtR), muscle mass-to-fat (MFR), mass-to-waist (MWR), shape (ABSI), in relation adults. Methods: Data from 13,725 participants Korea National Health Nutrition Examination Survey (2008–2011) were analyzed. The each indicator was assessed using receiver operating characteristic (ROC) curve analysis, area under (AUC) values compared. Participants classified into normal (NG) abnormal (AG) groups based established cutoff values, logistic regression analysis performed evaluate odds group. Results: WHtR showed highest AUC (0.792 men 0.768 women), indicating superior accuracy compared other (p < 0.001). Logistic indicated both unadjusted adjusted ratios (OR) higher AG than NG across all Specifically, OR (95% confidence interval) 6.793 (5.929–7.784) 4.665 (4.151–5.423) women, representing among Conclusion: Among most reliable practical predicting It useful intervention clinical public settings.

Language: Английский

---

Trends and Implications of Metabolic Syndrome in Korea, 2007-2022: A Nationwide Study

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Background This study analyzed the prevalence of metabolic syndrome (MetS) among Korean adults aged 19 and older over past 15 years. Methods A cross-sectional data from Korea National Health Nutrition Examination Survey (KNHANES) 2007 to 2022 was conducted. The included 87,397 subjects. MetS defined according Cholesterol Education Program-Third Adult Treatment Panel (NCEP-ATP) III Society for Study Obesity (KOSSO) criteria. Results increased 22.8% in 28.6% but showed sex differences, with males increasing (24.5–36.8%) females decreasing (20.6–19.5%). Among components MetS, hyperglycemia abdominal obesity most significant increases (1.51-fold 1.29-fold, respectively). While all age groups, 30–39 (1.98-fold) 19–29 (1.81-fold). Low high-density lipoprotein cholesterol (HDL-C) only component that decreased (0.62-fold) more prevalent females. In sub-analysis those 65 older, both Individuals had higher rates current smoking, heavy drinking, physical inactivity, carbohydrate consumption. Conclusions is gradually Korea, are rapidly increasing, especially younger males. Although due changes social environment, continuous efforts needed postmenopausal Targeted health policies interventions should be established.

Language: Английский

---

Comparing Non-alcoholic Fatty Liver Disease Indices in Predicting the Prevalence and Incidence of Metabolic Syndrome in Middle-Aged Adults

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e43073 - e43073

Published: March 1, 2025

Highlights•Compared FLI and HSI for predicting MetS in a 16-year community-based cohort.•FLI showed superior predictive power prevalence incidence over HSI.•Both indices were significantly associated with incidence.•Incorporating into clinical practice can enhance early detection of MetS.•FLI is valuable tool managing diverse populations.AbstractAimsThis study aimed to compare the non-alcoholic fatty liver disease (NAFLD), index (FLI), hepatic steatosis (HSI) metabolic syndrome (MetS) prospective cohort follow-up period.MethodsData from Ansan–Ansung Korean Genome Epidemiology Study used. We evaluated 8,271 participants 5,242 without at baseline incidence.ResultsThe was 30.5%. The prevalence, showing ability compared HSI. During period, 2,286 (43.6%) developed MetS. Both Time-dependent receiver operating characteristic curve analysis, Harrell's C-index, integrated discrimination improvement indicated that demonstrated better than HSI.ConclusionsGiven increasing its health implications, incorporating improve intervention strategies. Future research should investigate applicability populations role comprehensive management protocols.

Language: Английский

---

Metabolic diseases in the East Asian populations

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский

---