JACC Advances, Journal Year: 2024, Volume and Issue: 3(12), P. 101216 - 101216
Published: Sept. 25, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1902 - 1902
Published: Feb. 22, 2025
The underlying pathophysiology of aortic stenosis and factors affecting its clinical progression remain poorly understood. Apart from B-type natriuretic peptide (BNP), novel emerging biomarkers have been described in association with stenosis, emphasising the potential for these to illuminate on yet unknown mechanisms pathogenesis. In this review, we aimed summarise what is known about biomarkers, highlight ones, provide a roadmap translating insights into applications. Among studied, lipoprotein(a) [Lp(a)] has emerged as most promising risk stratification. Elevated Lp(a) levels are often associated more rapid progression. This detrimental effect attributed role promoting valve calcification. While other such matrix metalloproteinases, monocytes, metabolites show promises, their specific roles less clear. may be due relatively recent discovery. Ongoing research aims elucidate action.
Language: Английский
Citations
0
Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: 270, P. 108861 - 108861
Published: April 15, 2025
Sodium-glucose co-transporter 2 (SGLT2) inhibitors are oral antidiabetic agents that have shown significant improvements in cardiovascular and renal outcomes among patients with heart failure (HF), regardless of diabetic status, establishing them as a cornerstone therapy. In addition to glycemic control the osmotic diuretic effect, inhibition SGLT2 improves endothelial function vasodilation, optimizing myocardial energy metabolism preserving cardiac contractility. Moreover, may exhibit anti-inflammatory properties attenuate acute ischemia/reperfusion injury, thereby reducing infarct size, enhancing left ventricular function, mitigating arrhythmias. These pleiotropic effects demonstrated efficacy across various conditions, ranging from chronic coronary syndromes extending arrhythmias, valvular disease, cardiomyopathies, cardio-oncology, cerebrovascular disease. This review provides an overview current literature on potential mechanisms underlying effectiveness wide range diseases beyond HF.
Language: Английский
Citations
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JACC Advances, Journal Year: 2025, Volume and Issue: 4(5), P. 101750 - 101750
Published: April 25, 2025
Language: Английский
Citations
0
Expert Opinion on Therapeutic Targets, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15
Published: Oct. 30, 2024
With the growth of aging population, age-related diseases have become a heavy global burden, particularly cardiovascular and cerebrovascular (CVDs). Endothelial cell (EC) senescence constitutes an essential factor in development CVDs, prompting increased focus on strategies to alleviate or reverse EC senescence.
Language: Английский
Citations
1
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(23), P. 7256 - 7256
Published: Nov. 28, 2024
Cerebral embolic protection (CEP) during transcatheter aortic valve replacement (TAVR) has emerged as an important tool in reducing stroke risk associated with this intervention. With the recent expansion of TAVR into lower-risk populations, role preventive strategies gained greater significance. Despite advancements technologies, peri-procedural remains a significant complication, rates ranging between 2 and 5%. CEP devices, introduced at time procedure, have been developed to capture debris reduce neurological events. However, while MRI-detected is commonly captured by these clinical benefit debated. This review provides comprehensive analysis advances relevant research device development, offering recommendations for future studies improve patient outcomes.
Language: Английский
Citations
1
JACC Advances, Journal Year: 2024, Volume and Issue: 3(12), P. 101216 - 101216
Published: Sept. 25, 2024
Language: Английский
Citations
0