Large Transthyretin Aggregates in Plasma of ATTR Amyloidosis Patients DOI Creative Commons
Marianna Fontana,

Julian D. Gillmore,

Guglielmo Verona

et al.

JACC Basic to Translational Science, Journal Year: 2024, Volume and Issue: 9(9), P. 1101 - 1103

Published: Sept. 1, 2024

Language: Английский

Biomarkers in Subclinical Transthyretin Cardiac Amyloidosis DOI
Jaskeerat Gulati, Rose Pedretti, Nicholas Hendren

et al.

Current Heart Failure Reports, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 13, 2025

Language: Английский

Citations

0
Detection of ATTR aggregates in the plasma of polyneuropathic patients with ATTR-V30M amyloidosis DOI
Rose Pedretti, Lanie Wang, Justin L. Grodin

et al.

Amyloid, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 3

Published: Sept. 16, 2024

Language: Английский

Citations

2
ATTRv-V30M amyloid fibrils from heart and nerves exhibit structural homogeneity DOI
Binh A. Nguyen, Shumaila Afrin, Anna Yakubovska

et al.

Structure, Journal Year: 2024, Volume and Issue: 32(12), P. 2244 - 2250.e3

Published: Oct. 17, 2024

Language: Английский

Citations

2
ATTRv-V30M Type A amyloid fibrils from the heart and nerves exhibit structural homogeneity. DOI Creative Commons
Binh A. Nguyen, Shumaila Afrin, Anna Yakubovska

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

ATTR amyloidosis is a systemic disease characterized by the deposition of amyloid fibrils made transthyretin, protein integral to transporting retinol and thyroid hormones. Transthyretin primarily produced liver circulates in blood as tetramer. The retinal epithelium also secretes which secreted vitreous humor eye. Because mutations or aging, transthyretin can dissociate into amyloidogenic monomers triggering fibril formation. myocardium peripheral nerves causes cardiomyopathies neuropathies, respectively. Using cryo-electron microscopy, here we determined structures extracted from cardiac nerve tissues an ATTRv-V30M patient. We found that both share consistent structural conformation, similar previously described structure individual with same genotype, but different obtained humor. Our study hints uniform fibrillar architecture across within individual, only when source liver. Moreover, this provides first description patient enhances our understanding role site production shaping amyloidosis.

Language: Английский

Citations

1
Large Transthyretin Aggregates in Plasma of ATTR Amyloidosis Patients DOI Creative Commons
Marianna Fontana,

Julian D. Gillmore,

Guglielmo Verona

et al.

JACC Basic to Translational Science, Journal Year: 2024, Volume and Issue: 9(9), P. 1101 - 1103

Published: Sept. 1, 2024

Language: Английский

Citations

0