Circulation, Journal Year: 2015, Volume and Issue: 131(14), P. 1247 - 1259

Published: Jan. 31, 2015

The purpose of this study was to determine whether patients with heart failure and a preserved ejection fraction (HFpEF) have an increase in passive myocardial stiffness the extent which discovered changes depend on extracellular matrix fibrillar collagen cardiomyocyte titin.Seventy undergoing coronary artery bypass grafting underwent echocardiogram, plasma biomarker determination, intraoperative left ventricular epicardial anterior wall biopsy. Patients were divided into 3 groups: referent control (n=17, no hypertension or diabetes mellitus), (HTN) without (-) HFpEF (n=31), HTN (+) (n=22). One more following studies performed biopsies: measurements total, collagen-dependent titin-dependent (differential extraction assay), assays (biochemistry histology), titin isoform phosphorylation assays. In comparison controls, HTN(-)HFpEF had change end-diastolic pressure, stiffness, collagen, but biomarkers inflammation (C-reactive protein, soluble ST2, tissue inhibitor metalloproteinase 1). both HTN(-)HFpEF, HTN(+)HFpEF increased atrial volume, N-terminal propeptide brain natriuretic peptide, collagen-dependent, insoluble PEVK S11878(S26), reduced N2B S4185(S469), inflammation.Hypertension absence did not alter stiffness. significant stiffness; increased. These data suggest that development depends homeostasis.

Language: Английский