Ecotoxicology and Environmental Safety,
Journal Year:
2025,
Volume and Issue:
291, P. 117893 - 117893
Published: Feb. 1, 2025
Metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD)
and
air
pollution
are
both
significant
health
concerns.
However,
their
combined
effects
on
multi-system
morbidity
all-cause
mortality
remain
poorly
understood.
We
analyzed
data
from
434,417
UK
Biobank
participants,
categorizing
them
into
four
groups:
non-MAFLD,
MAFLD-diabetes,
MAFLD-lean,
MAFLD-overweight/obesity.
To
evaluate
the
long-term
of
exposure,
we
used
time-varying
Cox
proportional
hazard
models
to
assess
pollutants:
particulate
matter
with
an
aerodynamic
diameter
<
2.5
μm
(PM2.5),
PM10,
nitrogen
dioxide
(NO2),
oxides
(NOx).
examined
associations
between
these
pollutants,
MAFLD
subtypes,
joint
impact
mortality.
Furthermore,
explored
additive
multiplicative
interactions
pollutants
subtypes.
At
baseline,
15,325
participants
were
classified
as
3341
140,934
Among
groups,
MAFLD-diabetes
was
most
strongly
associated
adverse
outcomes
compared
other
Air
exposure
had
a
synergistic
effect
cirrhosis
risk
across
all
pronounced
observed
for
PM2.5
[relative
excess
due
interaction
(RERI):
2.10
(0.94,
3.26)]
NO2
[RERI:1.85
(0.67,
3.04)]
in
MAFLD-lean
group.
Positive
subtypes
also
coronary
artery
(CAD),
exception
oxide
Additionally,
only
demonstrated
positive
relation
chronic
kidney
(CKD).
This
study
highlights
distinct
impacts
mortality,
underscoring
critical
need
targeted
prevention
treatment
strategies,
particularly
individuals
MAFLD-diabetes.
Our
findings
reveal
risks
cirrhosis,
CAD,
CKD
among
patients.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 17, 2025
Abstract
This
study
aims
to
explore
the
relationship
between
sugar-sweetened
beverage
(SSB)
consumption
and
ischemic
stroke
(IS),
providing
scientific
evidence
for
preventive
measures.
In
this
study,
a
comprehensive
analysis
based
on
global
burden
of
disease
(GBD)
data
related
IS
from
1990–2021
was
conducted.
The
time
trends
age-standardized
mortality
rate
(ASMR)
disability-adjusted
life
year
(ASDR)
were
assessed
by
estimating
annual
percentage
change
(EAPC).
Although
ASMR
ASDR
have
declined,
number
deaths
years
(DALYs)
still
shown
increasing
1990–2021.
There
are
significant
differences
in
regions
with
varying
social
development
index
(SDI)
levels:
decreases
high-SDI
high–middle-SDI
but
increases
medium-SDI,
low–middle-SDI,
low-SDI
regions.
Additionally,
21
also
exhibited
similar
patterns.
2021,
China
reported
highest
deaths,
whereas
Romania
North
Macedonia
had
ASMRs.
Countries
such
as
Equatorial
Guinea
Ghana
showed
trend
IS-related
caused
SSB.
Inequality
revealed
that
1990–2021,
there
inequality
high
sugar
across
SDI
globally.
higher
than
regions,
although
gap
gradually
narrowed.
Further
stratified
indicated
changes
age
structure
population
growth
impacts
different
epidemiological
contributing
more
significantly
rate.
terms
sex,
men
slightly
women,
women
surpassed
those
aged
75
older.
results
(APC)
model
regional
rates
low-income
facing
serious
health
challenges.
Bayesian
age-period-cohort
(BAPC)
predictive
U-shaped
rates,
structure,
overall
is
expected
increase
significantly,
particularly
elderly
population.
BMJ Public Health,
Journal Year:
2025,
Volume and Issue:
3(1), P. e001539 - e001539
Published: Feb. 1, 2025
Introduction
This
study
aimed
to
examine
the
risk
of
common
diseases
among
people
with
pre-diabetes
and
explored
relationship
between
multimorbidity
(in
this
case,
two
or
more
comorbid
diseases).
Methods
An
observational
multicohort
using
data
from
UK
Biobank
database
National
Inpatient
Sample
(NIS)
(2016–2018)
was
conducted.
We
analysed
461
535
participants
17
548
442
patients
aged
18
years
older
both
databases,
whom
14.0%
0.7%
were
diagnosed
pre-diabetes,
respectively.
A
total
76
various
body
systems
selected
as
adverse
health
outcomes
for
analysis.
Results
Among
64
523
individuals
in
Biobank,
mean
age
60
years,
35
304
(54.7%)
female.
There
24
non-overlapping
associated
significant
multiple
test
results
most
them
are
circulatory
system
diseases.
Compared
normoglycaemia,
confounder-adjusted
HR
1.46
(95%
CI
1.43
1.49)
accompanying
complex
(ie,
four
pre-diabetes-related
diseases),
corresponding
OR
NIS
10.03
9.66
10.40).
Conclusion
Pre-diabetes
a
significantly
higher
multimorbidity.
Pre-diabetes,
thus,
might
represent
an
important
target
prevention,
stronger
emphasis
on
its
management
seems
necessary
reduce
development
comorbidities,
especially
before
onset
overt
diabetes.
Ecotoxicology and Environmental Safety,
Journal Year:
2025,
Volume and Issue:
291, P. 117893 - 117893
Published: Feb. 1, 2025
Metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD)
and
air
pollution
are
both
significant
health
concerns.
However,
their
combined
effects
on
multi-system
morbidity
all-cause
mortality
remain
poorly
understood.
We
analyzed
data
from
434,417
UK
Biobank
participants,
categorizing
them
into
four
groups:
non-MAFLD,
MAFLD-diabetes,
MAFLD-lean,
MAFLD-overweight/obesity.
To
evaluate
the
long-term
of
exposure,
we
used
time-varying
Cox
proportional
hazard
models
to
assess
pollutants:
particulate
matter
with
an
aerodynamic
diameter
<
2.5
μm
(PM2.5),
PM10,
nitrogen
dioxide
(NO2),
oxides
(NOx).
examined
associations
between
these
pollutants,
MAFLD
subtypes,
joint
impact
mortality.
Furthermore,
explored
additive
multiplicative
interactions
pollutants
subtypes.
At
baseline,
15,325
participants
were
classified
as
3341
140,934
Among
groups,
MAFLD-diabetes
was
most
strongly
associated
adverse
outcomes
compared
other
Air
exposure
had
a
synergistic
effect
cirrhosis
risk
across
all
pronounced
observed
for
PM2.5
[relative
excess
due
interaction
(RERI):
2.10
(0.94,
3.26)]
NO2
[RERI:1.85
(0.67,
3.04)]
in
MAFLD-lean
group.
Positive
subtypes
also
coronary
artery
(CAD),
exception
oxide
Additionally,
only
demonstrated
positive
relation
chronic
kidney
(CKD).
This
study
highlights
distinct
impacts
mortality,
underscoring
critical
need
targeted
prevention
treatment
strategies,
particularly
individuals
MAFLD-diabetes.
Our
findings
reveal
risks
cirrhosis,
CAD,
CKD
among
patients.
