JAMA Cardiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
Importance
The
Aspirin
and
Hemocompatibility
Events
With
a
Left
Ventricular
Assist
Device
in
Advanced
Heart
Failure
(ARIES-HM3)
study
demonstrated
that
aspirin
may
be
safely
eliminated
from
the
antithrombotic
regimen
after
HeartMate
3
(HM3
[Abbott
Cardiovascular])
left
ventricular
assist
device
(LVAD)
implantation.
This
prespecified
analysis
explored
whether
conditions
requiring
(prior
percutaneous
coronary
intervention
[PCI],
artery
bypass
grafting
[CABG],
stroke,
or
peripheral
vascular
disease
[PVD])
would
influence
outcomes
differentially
with
avoidance.
Objective
To
analyze
avoidance
on
hemocompatibility-related
adverse
events
(HRAEs)
at
1
year
implant
patients
history
of
CABG,
PCI,
PVD.
Design,
Setting,
Participants
was
an
international,
multicenter,
prospective,
double-blind,
placebo-controlled,
randomized
clinical
trial
including
implanted
de
novo
HM3
LVAD
across
51
centers.
Data
conducted
April
to
July
2024.
Interventions
Patients
were
1:1
ratio
receive
(100
mg
per
day)
placebo,
addition
vitamin
K
antagonist
(VKA)
targeted
international
normalized
2
both
groups.
Main
Outcomes
Measures
Primary
end
point
(assessed
for
noninferiority)
composite
survival
free
any
nonsurgical
(>14
days
implant)
HRAEs
pump
thrombosis,
bleeding,
arterial
thromboembolism
12
months.
Secondary
points
included
thrombosis
events.
Results
Among
589
628
(mean
[SD]
age,
57.1
[13.7]
years;
456
male
[77.4%])
who
contributed
primary
analysis,
PVD
present
41%
(240
patients).
There
no
interaction
between
presence
atherosclerotic
condition
effect
compared
placebo
(
P
interaction=
.23).
preset
10%
noninferiority
margin
not
crossed
studied
subgroup
patients.
Thrombotic
rare,
differences
without
=
.77).
treatment
associated
higher
rate
major
bleeding
group
prior
those
(rate
aspirin,
0.52;
95%
CI,
0.35-0.79).
Conclusions
Relevance
this
ARIES-HM3
demonstrate
advanced
heart
failure
have
classical
indications
antiplatelet
therapy
use
time
implantation,
safe
increased
risk.
Importantly,
elimination
but
reduction
Trial
registration
ClinicalTrials.gov
Identifier:
NCT04069156
КАРДИОЛОГИЯ УЗБЕКИСТАНА,
Journal Year:
2022,
Volume and Issue:
15(12), P. 1191 - 1201
Published: May 17, 2022
Currently,
transradial
access
(TRA)
is
the
recommended
for
coronary
procedures
because
of
increased
safety,
with
radial
artery
occlusion
(RAO)
being
its
most
frequent
complication,
which
will
increasingly
affect
patients
undergoing
multiple
during
their
lifetimes.
Recently,
distal
(DRA)
has
emerged
as
a
promising
alternative
to
minimize
RAO
risk.
A
large-scale,
international,
randomized
trial
comparing
TRA
and
DRA
lacking.
The
aim
this
study
was
assess
superiority
compared
conventional
respect
forearm
RAO.
DISCO
RADIAL
(Distal
vs
Conventional
Radial
Access)
an
multicenter,
controlled
in
indications
percutaneous
procedure
using
6-F
Slender
sheath
were
or
systematic
implementation
best
practices
reduce
primary
endpoint
incidence
assessed
by
vascular
ultrasound
at
discharge.
Secondary
endpoints
include
crossover,
hemostasis
time,
site–related
complications.
Overall,
657
underwent
TRA,
650
DRA.
Forearm
did
not
differ
between
groups
(0.91%
0.31%;
P
=
0.29).
Patent
achieved
94.4%
patients.
Crossover
rates
higher
(3.5%
7.4%;
0.002),
median
time
shorter
(180
153
minutes;
<
0.001).
spasm
occurred
more
(2.7%
5.4%;
0.015).
Overall
bleeding
events
complications
groups.
With
rigorous
protocol,
have
equally
low
rates.
associated
crossover
rate
but
time.
New England Journal of Medicine,
Journal Year:
2024,
Volume and Issue:
390(16), P. 1481 - 1492
Published: April 8, 2024
The
benefit
of
fractional
flow
reserve
(FFR)-guided
complete
revascularization
in
patients
with
ST-segment
elevation
myocardial
infarction
(STEMI)
and
multivessel
coronary
artery
disease
remains
unclear.
JACC Advances,
Journal Year:
2023,
Volume and Issue:
2(1), P. 100160 - 100160
Published: Jan. 1, 2023
Cardiovascular
multidisciplinary
heart
teams
(MDHTs)
have
evolved
significantly
over
the
past
decade.
These
play
a
central
role
in
treatment
of
wide
array
cardiovascular
diseases
affecting
interventional
cardiology,
cardiac
surgery,
imaging,
advanced
failure,
adult
congenital
disease,
cardio-oncology,
and
cardio-obstetrics.
To
meet
specific
needs
both
patients
programs,
composition
function
MDHTs
had
to
adapt
evolve.
Although
lessons
been
learned
from
cancer
care,
best
practices
for
operation
yet
be
defined,
evidence
base
supporting
their
effectiveness
is
limited.
This
expert
panel
review
discusses
history
evolution
MDHTs,
treating
across
broad
spectrum
disciplines,
basic
tenets
successful
operation,
future
challenges
facing
them.
JAMA Cardiology,
Journal Year:
2024,
Volume and Issue:
9(5), P. 437 - 437
Published: March 20, 2024
Importance
Among
patients
undergoing
percutaneous
coronary
intervention
(PCI),
it
remains
unclear
whether
the
treatment
efficacy
of
P2Y
12
inhibitor
monotherapy
after
a
short
course
dual
antiplatelet
therapy
(DAPT)
depends
on
type
inhibitor.
Objective
To
assess
risks
and
benefits
ticagrelor
or
clopidogrel
compared
with
standard
DAPT
PCI.
Data
Sources
MEDLINE,
Embase,
TCTMD,
European
Society
Cardiology
website
were
searched
from
inception
to
September
10,
2023,
without
language
restriction.
Study
Selection
Included
studies
randomized
clinical
trials
comparing
adjudicated
end
points
in
indication
oral
anticoagulation
Extraction
Synthesis
Patient-level
data
provided
by
each
trial
synthesized
into
pooled
dataset
analyzed
using
1-step
mixed-effects
model.
The
study
is
reported
following
Preferred
Reporting
Items
for
Systematic
Review
Meta-Analyses
Individual
Participant
Data.
Main
Outcomes
Measures
primary
objective
was
determine
noninferiority
vs
composite
death,
myocardial
infarction
(MI),
stroke
per-protocol
analysis
1.15
margin
hazard
ratio
(HR).
Key
secondary
major
bleeding
net
adverse
events
(NACE),
including
point
bleeding.
Results
Analyses
included
6
25
960
PCI,
whom
24
394
(12
403
receiving
DAPT;
8292
monotherapy;
3654
45
prasugrel
monotherapy)
retained
analysis.
Trials
conducted
Asia,
Europe,
North
America;
all
Asia.
Ticagrelor
noninferior
(HR,
0.89;
95%
CI,
0.74-1.06;
P
=
.004),
but
not
1.37;
1.01-1.87;
&gt;
.99),
this
finding
driven
noncardiovascular
death.
risk
lower
both
0.47;
0.36-0.62;
&lt;
.001)
0.49;
0.30-0.81;
.006;
interaction
0.88).
NACE
0.74;
0.64-0.86,
1.00;
0.78-1.28;
.99;
.04).
Conclusions
Relevance
This
systematic
review
meta-analysis
found
that
all-cause
MI,
superior
NACE.
Clopidogrel
similarly
associated
reduced
stroke,
largely
because
observed
1
exclusively
East
Asian
an
excess
Cardiovascular Diabetology,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: June 29, 2023
Insulin
resistance
(IR)
has
been
confirmed
that
getting
involved
in
the
pathophysiological
process
of
cardiovascular
diseases
(CVD).
Recently,
increasing
evidence
suggests
metabolic
score
for
insulin
(METS-IR),
triglyceride
to
high-density
lipoprotein
cholesterol
(TG/HDL-C)
ratio,
and
glucose
(TyG)
index,
glucose-body
mass
(TyG-BMI)
index
are
simple
reliable
surrogates
IR.
However,
their
abilities
predicting
outcomes
patients
undergoing
percutaneous
coronary
intervention
(PCI)
not
well
explored.
Therefore,
this
study
aimed
investigate
association
evaluate
predictive
performance
each
index.A
total
2533
consecutive
participants
PCI
were
included
study,
data
from
1461
used
determine
correlation
these
non-insulin-based
IR
indices
with
major
adverse
cardiac
cerebrovascular
events
(MACCEs)
via
performing
multivariate
logistic
models
restricted
cubic
splines
(RCS).During
a
median
29.8
months
follow-up,
195
cases
experienced
incident
MACCEs.
In
overall
population,
both
univariate
regression
analyses
indicated
no
statistically
significant
connection
between
Subgroup
revealed
interactions
age
subgroups
TyG-BMI
as
METS-IR,
sex
TyG
index.
elderly
patients,
per
1.0-SD
increment
METS-IR
had
MACCEs,
odds
ratios
(ORs)
[95%
confidence
interval
(CI)]
1.24
(1.02-1.50)
1.27
(1.04-1.56),
respectively
(both
P
<
0.05).
Moreover,
female
all
showed
associations
Multivariable-adjusted
RCS
curves
demonstrated
linear
relationship
MACCEs
respectively.
failed
enhance
basic
risk
model
MACCEs.All
four
individuals,
whereas
only
patients.
Although
inclusion
did
improve
power
either
or
appears
be
most
promising
secondary
prevention
stratification
PCI.