Association of clonal haematopoiesis with recurrent venous thromboembolism: A case–control study DOI Creative Commons
Cornelia Englisch,

Rafaela Vostatek,

Theresa Schramm

et al.

British Journal of Haematology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Summary Venous thromboembolism (VTE) is the third most common cardiovascular disease. Clonal haematopoiesis (CH) linked to disease risk, but its potential association with VTE remains poorly understood. We assessed prevalence of CH in patients recurrent ( n = 107; median age [IQR] 57 [48–63] years, 44.9% female) and matched healthy controls 127; 53 [45–60] 51.2% investigate a putative risk. detected 12 CH‐associated mutations 11 (10.3%) cases six 5 (3.9%) controls. Thus, tended have higher odds presenting compared (OR: 2.74, 95% CI: 0.95–9.16). Moreover, detecting were significantly subgroup individuals without thrombophilia 4.58, 1.48–15.99). showed elevated platelet counts (median [IQR]: 292 [254–298], 223 [198–260] 220 [185–259] × 10 9 /L; both p < 0.01). Fibrinogen, sP‐selectin, D‐dimer hsCRP levels did not differ according status. Overall, we identified trend for an between VTE, particularly underlying thrombophilia, warranting further research this patient group.

Language: Английский

Clonal hematopoiesis, cardiovascular disease and cancer treatment-induced cardiotoxicity DOI

Nan Zhang,

Xu Tian, Dong-Kun Sun

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Clonal Hematopoiesis and Thrombosis DOI Creative Commons
Cornelia Englisch, Cihan Ay

American Journal of Hematology, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

ABSTRACT Clonal hematopoiesis (CH) has been the focus of many research efforts in last years and emerged as a risk modifier for cardiovascular disease morbidity mortality. While substantial evidence accumulated regarding its impact on arterial system diseases, connection with venous thrombosis only recently explored. Both clinical preclinical suggest that magnitude mechanism underlying association CH events vary depending specific mutated gene involved, indicating causal link between development, not system, particularly context atherosclerosis, but also thrombosis. Although this growing body knowledge driven translational provided insights improving management, several questions remain unanswered. This review aims to summarize available thrombosis, while highlighting gaps need be addressed future research.

Language: Английский

Citations

0
Clonal Hematopoiesis Among Patients With Asymptomatic Carotid Stenosis Compounds Risk of Cardiovascular Death DOI
Pradeep Natarajan,

Tiffany R Bellomo

Journal of the American College of Cardiology, Journal Year: 2024, Volume and Issue: 83(18), P. 1728 - 1730

Published: April 29, 2024

Language: Английский

Citations

0
Myeloproliferative Neoplasms and Cardiovascular Disease: A Review DOI
Orly Leiva, Olivia Liu,

Sophia Zhou

et al.

Current Treatment Options in Oncology, Journal Year: 2024, Volume and Issue: 25(10), P. 1257 - 1267

Published: Sept. 16, 2024

Language: Английский

Citations

0
Association of clonal haematopoiesis with recurrent venous thromboembolism: A case–control study DOI Creative Commons
Cornelia Englisch,

Rafaela Vostatek,

Theresa Schramm

et al.

British Journal of Haematology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Summary Venous thromboembolism (VTE) is the third most common cardiovascular disease. Clonal haematopoiesis (CH) linked to disease risk, but its potential association with VTE remains poorly understood. We assessed prevalence of CH in patients recurrent ( n = 107; median age [IQR] 57 [48–63] years, 44.9% female) and matched healthy controls 127; 53 [45–60] 51.2% investigate a putative risk. detected 12 CH‐associated mutations 11 (10.3%) cases six 5 (3.9%) controls. Thus, tended have higher odds presenting compared (OR: 2.74, 95% CI: 0.95–9.16). Moreover, detecting were significantly subgroup individuals without thrombophilia 4.58, 1.48–15.99). showed elevated platelet counts (median [IQR]: 292 [254–298], 223 [198–260] 220 [185–259] × 10 9 /L; both p < 0.01). Fibrinogen, sP‐selectin, D‐dimer hsCRP levels did not differ according status. Overall, we identified trend for an between VTE, particularly underlying thrombophilia, warranting further research this patient group.

Language: Английский

Citations

0