Published: Jan. 1, 2024
Language: Английский
Canadian Journal of Cardiology, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
The optimal approach to repeat catheter ablation for recurrent paroxysmal atrial fibrillation (PAF) is unknown. Consecutive patients undergoing PAF were studied. A six-step was used in all cases: re-isolation of reconnected pulmonary veins (PVs), left low voltage areas (LVAs), targeted clinical or inducible flutter/tachycardia, non-PV trigger ablation, supraventricular tachycardia, and additional empiric based on operator judgment. primary study outcome arrhythmia-free survival at 1-year. 113 included (age 63.7±8.6 years, 28.3% female). In this cohort, 73.5% had PV reconnection(s); 31.9% LVAs; 10.6% identifiable triggers; 5.3% atrioventricular nodal reentrant tachycardia; underwent flutter/tachycardia ablation; 12.4% performed. Arrhythmia-free 1-year 53.1%. Patients with arrhythmia recurrence more likely be older, female, have hypertension, durably isolated PVs, undergone LVA ablation. multivariable analysis, female sex remained predictive recurrence. Among only (negatively) associated procedural success. comprehensive protocol resulted 53% patients. Durably PVs observed 26.5%. None the protocol's steps suggested independently improve Further research determine strategy needed, a growing proportion whom are expected PVs.
Language: Английский
Citations
1
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(24), P. 7700 - 7700
Published: Dec. 17, 2024
Atrial fibrillation (AF) is the leading cause of arrhythmia-related morbidity and mortality. Recurrent symptoms, hospitalizations, cost burden to patients have necessitated treatments beyond antiarrhythmic drugs (AADs) for with AF. Catheter ablation has proven be effective over medical therapy alone; however recurrence rates atrial tachyarrhythmias post-ablation remain significant, particularly in persistent long-standing Hence, new techniques catheter arisen, such as non-thermal energy sources, novel catheters, electroanatomical mapping, additional targets. In this review, we discuss recent advances field ablation, including newer modalities prevention adverse events future perspectives.
Language: Английский
Citations
4
Journal of the American College of Cardiology, Journal Year: 2025, Volume and Issue: 85(1), P. e7 - e7
Published: Jan. 1, 2025
Language: Английский
Citations
0
Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 24, 2025
The primary electrophysiological mechanism of atrial fibrillation (AF) maintenance is poorly defined. AF mapping studies readily record focal activations (defining them as sources or breakthroughs) and “incomplete reentries” reentries would-be-reentries) but do not rarely detect complete circular activations. Electrophysiological alterations induced by anti-AF drugs before cardioversion may help delineate the maintenance. Cardioversion antiarrhythmic associated with prolongation cycle length temporal excitable gap (t-EG), resulting in improvement organization (AF-org), without refractory period, conduction velocity wavelength. Such pattern conceivable termination a single source reentry (Class III agents increase reentrant t-EG). Yet, multiple are plausible prior drug administration. Improvement AF-org caused coherent simultaneous random wavelets. However, unlikely to occur regularly (most contemporary report either at time no all), ability wavelets maintain speculative. conducted analysis inclines toward
Language: Английский
Citations
0
JACC. Clinical electrophysiology, Journal Year: 2025, Volume and Issue: 11(1), P. 43 - 45
Published: Jan. 1, 2025
Language: Английский
Citations
0
The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown
Published: March 7, 2025
Atrial fibrillation (AF) is a complex arrhythmia. Various modulating factors influence its triggers and substrate. Fibroblasts, adipocytes, inflammatory cells the coagulation system can disrupt cardiomyocyte function. Cardiomyocytes fibroblasts release cytokines that promote local systemic inflammation, enhancing fibroblast activation extracellular matrix deposition, leading to myocardial fibrosis. Fibrosis essential for induction of reentrant arrhythmias, including AF. Adipocytes contribute arrhythmogenesis by secreting pro-inflammatory pro-fibrotic factors, exacerbating inflammation metabolic dysregulation. Inflammatory mediators activate system, which augments this vicious cycle producing promoting fibrosis arrhythmias at same time as increasing risk thrombosis. Understanding these interconnected roles in development progress atrial arrhythmogenic substrate may point potential novel therapeutic targets stabilise or antagonise eventually prevent This review examines role interplay between cardiomyocytes, fibroblasts, contributing AF initiation perpetuation.
Language: Английский
Citations
0
JACC. Clinical electrophysiology, Journal Year: 2025, Volume and Issue: 11(4), P. 749 - 751
Published: April 1, 2025
Language: Английский
Citations
0
Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 1588 - 1594
Published: Jan. 1, 2025
Language: Английский
Citations
0
Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156555 - 156555
Published: Feb. 22, 2025
Language: Английский
Citations
0
Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: 35(2), P. 103726 - 103726
Published: Aug. 30, 2024
Language: Английский
Citations
2