Cited by Education and information to reduce aortic aneurysm mortality rates

Which Parameter Related to Low-Density Lipoprotein Cholesterol is Superior for Predicting the Recurrence of Myocardial Infarction in Young Patients with Previous Coronary Heart Disease? A Real-World Study DOI

Feng Xu,

Haoran Xing,

Hongxia Yang

et al.

Reviews in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 20, 2025

Background: Lowering low-density lipoprotein cholesterol (LDL-C) is a well-established strategy for the secondary prevention of coronary heart disease (CHD). However, effectiveness specific LDL-C parameters in predicting myocardial infarction (MI) recurrence real-world settings remains inadequately explored. This study aims to examine relationship between MI and various young CHD patients. Methods: retrospective cohort involved 1013 patients aged 18–44 at time initial diagnosis, collected from cardiology department clinics Beijing Anzhen Hospital October 2022 2023. levels were assessed diagnosis final follow-up. The primary outcome was events, analyzed using survival analysis logistic regression models determine associations with parameters. Results: included (mean age: 38.5 ± 3.9 years; 94.7% men), median follow-up 1.7 years. Initially, 13.6% had <1.8 mmol/L, which increased 37.8% by study’s end. During follow-up, 96 (9.5%) experienced MI. While mmol/L baseline showed slightly lower cumulative incidence than ≥1.8 difference not statistically significant (log-rank p = 0.335). Reductions ≥50% patterns change did correlate decreased risk. <1.4 measurement associated reduced risk (adjusted odds ratio [OR]: 0.57, 95% confidence interval [CI]: 0.33–0.98) compared ≥2.6 mmol/L. Conclusions: suggests that most important parameter related history ideal target level. could potentially reduce risk, regardless levels.

Language: Английский

Citations

Polymeric Nanomaterials for Atherosclerosis Diagnosis and Treatment DOI

Xiaoming Liu, Kailu Zhang,

Mingming Yin

et al.

Polymer science & technology., Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

Citations

Effects of life-long hyperlipidaemia on age-dependent development of endothelial dysfunction in humanised dyslipidaemic mice DOI

Anna Bar, Piotr Berkowicz, Anna Kurpińska

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract Little is known, how life-long hyperlipidaemia affects vascular ageing, before atherosclerosis. Here, we characterise effects of mild, on age-dependent endothelial dysfunction (ED) in humanised dyslipidaemia model E3L.CETP mice. Vascular function was characterised using magnetic resonance imaging vivo and wire myograph ex vivo. Plasma biomarkers non-targeted proteomics plasma aorta were analysed. Early atherosclerosis lesions occasionally present only 40-week-old or older However, ED developed earlier, 14-week-old male 22-week-old female mice as compared with C57BL/6J Acetylcholine-induced vasodilation 8-week-old E3L.CETP, especially mice, blocked by catalase attributed to H 2 O . In changes proteome response modest, while a number differentially expressed proteins identified that involved oxidative stress response, inflammation regulation metabolic pathways. contrast, either aortic displayed similar pattern dominating over hyperlipidaemia-induced changes. Interestingly, 48-week-old but not mitochondrial functional impaired. resilience detrimental young level associated switch mechanism, blunted systemic proteomic slower development The results indicate profile early risk factors age may determine development.

Language: Английский

Citations

Targeted drug delivery systems for atherosclerosis DOI

Liangxing Tu,

Zijian Zou,

Yang Ye

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 23, 2025

Atherosclerosis is a complex cardiovascular disease driven by multiple factors, including aging, inflammation, oxidative stress, and plaque rupture. The progression of this often covert, emphasizing the need for early biomarkers effective intervention measures. In recent years, advancements in therapeutic strategies have highlighted potential targeting specific processes atherosclerosis, such as localization, macrophage activity, key enzymes. Based on this, review discusses role targeted drugs treatment atherosclerosis. It also focuses their clinical efficacy anti-atherosclerosis ability to provide more precise approaches. findings underscore that future research can concentrate exploring newer drug delivery systems further refine enhance long-term dynamic management

Language: Английский

Citations

From geroscience to precision geromedicine: Understanding and managing aging DOI

Guido Kroemer, Andrea B. Maier, Ana María Cuervo

et al.

Cell, Journal Year: 2025, Volume and Issue: 188(8), P. 2043 - 2062

Published: April 1, 2025

Language: Английский

Citations

New Approaches to Lipoproteins for the Prevention of Cardiovascular Events DOI

Masashi Fujino, Giuseppe Di Giovanni, Stephen J. Nicholls

et al.

Journal of Atherosclerosis and Thrombosis, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Atherosclerotic cardiovascular disease (ASCVD) is a leading global cause of mortality, and recent research has underscored the critical role lipoproteins in modulating (CV) risk. Elevated low-density lipoprotein cholesterol (LDL-C) levels have been linked to increased CV events, while numerous trials confirmed efficacy lipid-lowering therapies (LLT), significant gaps remain between recommended LDL-C targets real-world clinical practice. This review addresses care LLT, emphasizing necessity for innovative approaches that extend beyond management. It explores combination therapy such as statins combined with ezetimibe or PCSK9 inhibitors, which shown promise enhancing reduction improving outcomes high-risk patients. Additionally, this discusses new lipid modification strategies, including bempedoic acid, inclisiran, drugs lower Lp(a), highlighting their potential risk reduction. Furthermore, it emphasizes polygenic scores guide LLT lifestyle changes despite challenges implementation genetic testing ethics. article current guidelines proposes optimizing management, ultimately contributing improved patient ASCVD prevention.

Language: Английский

Citations

EF24, a Curcumin Analog, Reverses Interleukin-18-Induced miR-30a or miR-342-Dependent TRAF3IP2 Expression, RECK Suppression, and the Proinflammatory Phenotype of Human Aortic Smooth Muscle Cells DOI

Yusuke Higashi, Ryan J. Dashek, Patrice Delafontaine

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(20), P. 1673 - 1673

Published: Oct. 10, 2024

Curcumin, a polyphenolic compound derived from the widely used spice

Language: Английский

Citations

Deep Learning-Based Detection of Carotid Plaques Informs Cardiovascular Risk Prediction and Reveals Genetic Drivers of Atherosclerosis DOI

Murad Omarov, Lanyue Zhang, Saman Doroodgar Jorshery

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 18, 2024

Abstract Atherosclerotic cardiovascular disease, the leading cause of global mortality, is driven by lipid accumulation and plaque formation within arterial walls. Carotid plaques, detectable via ultrasound, are a well-established marker subclinical atherosclerosis. In this study, we trained deep learning model to detect plaques in 177,757 carotid ultrasound images from 19,499 UK Biobank (UKB) participants (aged 47-83 years) assess prevalence, risk factors, prognostic significance, genetic architecture atherosclerosis large population-based cohort. The demonstrated high performance metrics with accuracy, sensitivity, specificity, positive predictive value 89.3%, 89.5%, 89.2%, 82.9%, respectively, identifying 45% population. Plaque presence count were significantly associated future events over median follow-up period up 7 years, improved reclassification beyond established clinical prediction models. A genome-wide association study (GWAS) meta-analysis (29,790 cases, 36,847 controls) uncovered two novel genomic loci (p < 5×10 −8 ) downstream analyses implicating lipoprotein(a) interleukin-6 signaling, both targets investigational drugs advanced development. Observational Mendelian randomization showed associations between smoking, low-density-lipoprotein (LDL) cholesterol, blood pressure odds presence. Our underscores potential assessment for improving prediction, provides insights into basis atherosclerosis, offers valuable resource advancing research at population scale.

Language: Английский

Citations

ECH 1 attenuates atherosclerosis by reducing macrophage infiltration and improving plaque stability through CD36 degradation DOI

Caijun Rao, Haojie Qin, Zhipeng Du

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown, P. 110217 - 110217

Published: Nov. 1, 2024

Language: Английский

Citations

Education and information to reduce aortic aneurysm mortality rates DOI

Michael Huy Cuong Pham, Shoaib Afzal, Klaus F. Kofoed

et al.

European Heart Journal - Cardiovascular Imaging, Journal Year: 2024, Volume and Issue: 25(10), P. e250 - e250

Published: Aug. 17, 2024

Journal Article Accepted manuscript Education and Information to Reduce Aortic Aneurysm Mortality Rates Get access Michael Huy Cuong Pham, MD, MD Department of Cardiology, The Heart Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, DenmarkDepartment Radiology, Diagnostic Denmark Address for correspondence: Cardiology & 2014, Rigshospitalet Clinical Medicine, Faculty Health Medical Sciences, Blegdamsvej 9, 2100-CPH, Denmark, E-mail: [email protected], Phone: +45 60590202 Mobile: https://orcid.org/0000-0002-6577-0079 Search other works by this author on: Oxford Academic PubMed Google Scholar Shoaib Afzal, PhD, DMSc, DMSc https://orcid.org/0000-0002-1442-4694 Klaus Fuglsang Kofoed, https://orcid.org/0000-0001-9742-1554 European Cardiovascular Imaging, jeae208, https://doi.org/10.1093/ehjci/jeae208 Published: 17 August 2024 history Received: 24 July Accepted: 09

Language: Английский

Citations