Coronary Plaque Characteristics Assessed by Optical Coherence Tomography and Plasma Lipoprotein(a) Levels in Patients With Acute Coronary Syndrome DOI Creative Commons
Francesca Maria Di Muro,

Maria Federica Crociani,

Giulia Nardi

et al.

Catheterization and Cardiovascular Interventions, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Lipoprotein(a) [Lp(a)] is associated with increased cardiovascular risk, but its influence on plaque characteristics at optical coherence tomography (OCT) evaluation not fully understood.

Language: Английский

Evidence for a causal link between lipoprotein (a) and mental disorders: A retrospective and Mendelian randomization study DOI
Guanrui Pan,

Qingan Fu,

Yuan Xu

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 374, P. 397 - 407

Published: Jan. 12, 2025

Language: Английский

Citations

0
ApoB-containing lipoproteins: count, type, size, and risk of coronary artery disease DOI
Jakub Morze, Giorgio Melloni, Clemens Wittenbecher

et al.

European Heart Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Background and Aims Apolipoprotein B concentration reflects the number of atherogenic lipoproteins is recognized as a key lipid risk marker. Whether type or size apoB particle (apoB-P) adds predictive value for coronary artery disease (CAD) remains unclear. Methods A prospective analysis 207 368 UK Biobank participants with comprehensive lipoprotein profiling no prior history atherosclerotic disease, diabetes, active lipid-lowering therapy was conducted. Multivariable-adjusted Cox regression models were used to examine association between each following parameters incident CAD: (i) nuclear magnetic resonance-measured apoB-P, (ii) concentrations individual classes [very-low-density (VLDL), low-density (LDL)], (iii) subclasses, (iv) average diameter, (v) immunoassay-measured lipoprotein(a) [Lp(a)]. Results one standard deviation (SD) increase in apoB-P associated 33% higher CAD [hazard ratio (HR): 1.33, 95% CI: 1.30–1.36]. Although VLDL particles observed carry per-particle (HR per 100 nmol/L: 1.22, 1.11–1.34) compared LDL 1.07, 1.05–1.08), this difference counterbalanced after considering relative abundance (LDL 91% vs 9% total apoB-P). Thus respective HR 1-SD 1.09 (1.05–1.14) 1.24 (1.19–1.30). Particle diameter subclasses not adjustment. The Lp(a) robust even adjustment (HR:1.18, 1.16–1.20) added independent prognostic (area under curve: 0.769 0.774, P < .001). Conclusions Lipid-related most accurately reflected by count largely unaffected major (VLDL, LDL) size. Elevated additional risk, thus adequate assessment from dyslipidemia best accomplished consideration both concentrations.

Language: Английский

Citations

0
Lipoprotein(a) and the atherosclerotic burden – should we wait for clinical trial evidence before taking action? DOI Creative Commons

Isabella Fichtner,

Chiara Macchi, Alessandra Stefania Rizzuto

et al.

Atherosclerosis Plus, Journal Year: 2024, Volume and Issue: 58, P. 16 - 23

Published: Sept. 26, 2024

Language: Английский

Citations

2
In Search of an Accurate Measurement of LDL-C DOI
Sotirios Tsimikas,

Calvin Yeang,

Florian Kronenberg

et al.

Journal of the American College of Cardiology, Journal Year: 2024, Volume and Issue: 84(2), P. 178 - 181

Published: July 1, 2024

Language: Английский

Citations

1
Lipoprotein(a) and risk-weighted apolipoprotein B: a novel metric for atherogenic risk DOI Creative Commons
M. Rehman, Benoît Tudrej

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 27, 2024

Language: Английский

Citations

1
Coronary Plaque Characteristics Assessed by Optical Coherence Tomography and Plasma Lipoprotein(a) Levels in Patients With Acute Coronary Syndrome DOI Creative Commons
Francesca Maria Di Muro,

Maria Federica Crociani,

Giulia Nardi

et al.

Catheterization and Cardiovascular Interventions, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Lipoprotein(a) [Lp(a)] is associated with increased cardiovascular risk, but its influence on plaque characteristics at optical coherence tomography (OCT) evaluation not fully understood.

Language: Английский

Citations

0