Incidence and Risk Factors for Developing Type 2 Diabetes Mellitus After Acute Myocardial Infarction—A Long-Term Follow-Up

Journal of Cardiovascular Development and Disease, Journal Year: 2025, Volume and Issue: 12(3), P. 89 - 89

Published: Feb. 28, 2025

Acute myocardial infarction (AMI) and type 2 diabetes mellitus (T2DM) share common risk factors. To evaluate the long-term incidence predictors of new-onset T2DM (NODM) among post-AMI adults, we conducted a retrospective analysis AMI survivors hospitalized between 2002 2017. Eligible patients were followed for up to 16 years identify NODM, stratified by demographic clinical characteristics. Among 5147 individuals (74.2% males, mean age 64.6 ± 14.9 years) without pre-existing T2DM, 23.4% developed NODM (cumulative incidence: 0.541). Key factors included an 50–60 years, minority ethnicity (Arabs), smoking, metabolic syndrome (MetS), hemoglobin A1C (HbA1C) ≥ 5.7%, cardiovascular comorbidities. A total score (TS), integrating these factors, revealed linear association with risk: each 1-point increase corresponded 1.2-fold rise (95% CI 1.191–1.276, p < 0.001). HbA1C 6% on “Pre-DM sub-scale” conferred 2.8-fold (p 0.001), while other also independently predicted NODM. In conclusion, multiple particularly middle-aged individuals, Arab those or MetS, are at heightened Early identification targeted interventions may mitigate this risk.

Language: Английский

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Metabolic Regulation and Cardiorenal Protection: Deciphering the Potential and Multi-Target Mechanisms of Jiangtang Qingre Formula for Type 2 Diabetes Management

Published: Jan. 1, 2025

Language: Английский

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Cardiovascular abnormalities already occurred in newly-diagnosed patients with early-onset type 2 diabetes

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 26, 2025

The prevalence of early-onset type 2 diabetes (EOD) is rapidly increasing. This study intends to screen for early cardiovascular abnormalities in patients newly diagnosed with EOD and evaluate the risk across cluster phenotypes. A total 400 ≤ 40 years old were enrolled from START cohort (the Study diAgnosed eaRly onset diabeTes). Cluster classification was performed using K-means method based on age, BMI, HbA1c, HOMA2-β, HOMA2-IR, GAD antibodies. Echocardiography carotid ultrasound within 3 months diagnosis. Carotid included intimal thickening plaque formation, while echocardiography assessed changes cardiac structure systolic/diastolic function. Cluster-specific partitioned polygenic scores (pPS) used validate our findings a genetic perspective. artery detected 26.3% patients, observed 20.0%. Patients severe insulin resistant (SIRD) had highest incidence abnormality (40.0%). After adjusting relevant factors, fasting C-peptide levels significantly associated 1.247-fold increase abnormalities. Left atrial enlargement more prevalent SIRD (16.7%) mild obesity-related (MOD) (18.5%) classifications. high proportion abnormal left ventricular geometry (36.1%). Increases level HOMA2IR accompanied by further 1.136-, 1.781- 1.687-fold respectively. pPS lipodystrophy higher group showed significant linear correlation ratio anteroposterior diameter body surface area (LAAP/BSA) (R = 0.344, p < 0.001). Heart are common T2DM at time obesity resistance clinical characteristics enables accurate identification increased complications an stage.

Language: Английский

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Liver steatosis is positively associated with plasminogen activator inhibitor-1 in apparently healthy individuals with overweight and obesity: A FibroScan-Based Cross-Sectional study

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 29, 2025

Language: Английский

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The “Ticking Clock” of Impending Diabetes

Journal of the American College of Cardiology, Journal Year: 2024, Volume and Issue: 84(23), P. 2260 - 2263

Published: Nov. 25, 2024

Language: Английский

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