Anticancer Chemotherapy-Induced Atherosclerotic Cardiovascular Disease: A Comprehensive Review

Life, Journal Year: 2025, Volume and Issue: 15(2), P. 245 - 245

Published: Feb. 6, 2025

The introduction of anticancer agents has transformed oncology, significantly improving survival rates. However, these therapies have introduced unintended cardiovascular risks, with atherosclerovascular disease (ASCVD) emerging as a leading cause morbidity and mortality among cancer survivors. development ASCVD in this population involves multifactorial mechanisms, including endothelial dysfunction, oxidative stress, systemic inflammation, disrupted lipid metabolism. This review examines the various mechanisms through which chemotherapy contributes to highlights strategies for risk assessment management. Each class presents distinct challenges: anthracyclines induce stress damage, promoting foam cell formation plaque progression; taxanes vascular growth factor (VEGF) inhibitors impair metabolism stability; anti-metabolites exacerbate injury reactive oxygen species; mTOR inhibitors, hormonal therapies, tyrosine kinase immune checkpoint disrupt profiles inflammatory pathways, increasing rupture thrombosis. Mitigating chemotherapy-induced necessitates comprehensive, multidisciplinary approach. Detailed pre-treatment assessments must address traditional cancer-specific factors, demographics, pre-existing conditions, modifiable behaviors such smoking inactivity. Pharmacological interventions like statins angiotensin-converting enzyme (ACE) paired lifestyle modifications, are essential reducing risk. In resource-limited settings, cost-effective should be prioritized enhance accessibility. Establishing cardio-oncology units facilitates care coordination, while long-term surveillance enables timely detection intervention. These collectively improve outcomes survivorship diverse patient populations.

Language: Английский

Cancer Prevention and Early Detection in Patients With Cardiovascular Disease

JACC CardioOncology, Journal Year: 2024, Volume and Issue: 6(6), P. 962 - 964

Published: Dec. 1, 2024

Language: Английский